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( Seong Yeol Ryu ),( Won-ki Baek ),( Hyun Ah Kim ) 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.2
Background/Aims: The pathogen Acinetobacter baumannii is increasingly causing healthcare-associated infections worldwide, particularly in intensive care units. Biofilm formation, a factor contributing to the virulence of A. baumannii, is associated with long-term persistence in hospital environments. The present study investigates the clinical impact of biofilm production on colonization and acquisition after patient admission. Methods: Forty-nine A. baumannii isolates were obtained between August and November 2013 from Keimyung University Dongsan Medical Center, Daegu, Korea. All isolates were obtained from sputum samples of new patients infected or colonized by A. baumannii. The microtiter plate assay was used to determine biofilm formation. Results: Twenty-four A. baumannii isolates (48%) demonstrated enhanced biofilm formation capacity than that of the standard A. baumannii strain (ATCC 19606). All isolates were resistant to carbapenem, 38 isolates (77%) were collected from patients in an intensive care unit, and 47 isolates (95%) were from patients who had been exposed to antibiotics in the previous month. The median duration of colonization was longer for biofilm-producing isolates than that of the biofilm non-biofilm producing isolates (18 days vs. 12 days, p < 0.05). Simultaneous colonization with other bacteria was more common for biofilm-producing isolates than that for the non-biofilm producing isolates. The most prevalent co-colonizing bacteria was Staphylococcus aureus. Conclusions: Biofilm-producing isolates seem to colonize the respiratory tract for longer durations than the non-biofilm producing isolates. During colonization, biofilm producers promote co-colonization by other bacteria, particularly S. aureus. Additional research is required to determine possible links between biofilm formation and nosocomial infection.
불명열 환자의 원인 질환 및 악성종양 예측인자에 대한 분석
류성열 ( Seong Yeol Ryu ),허상택 ( Sang Taek Heo ),권기태 ( Ki Tae Kwon ),오원섭 ( Won Sup Oh ),백경란 ( Kyong Ran Peck ),송재훈 ( Jae Hoon Song ) 대한내과학회 2006 대한내과학회지 Vol.71 No.3
목적: 불명열은 흔히 임상에서 접하는 질환이나, 원인질환의 진단에 있어서는 많은 어려움을 겪는데, 불명열 원인질환의 분석은 불명열의 진단에 도움이 되는바, 1995년부터 2005년까지 약 10년간 시기에 따른 원인질환의 변화 양상 및 악성 종양 예측인자를 분석 하고자 하였다. 방법: 삼성 서울병원에 1995년 1월부터 2005년 8월까지 고전적 불명열 진단을 받고 퇴원한 환자를 대상으로 하여 입원기록과 외래기록을 검토하여 후향적으로 연구를 시행하였다. 결과: 불명열 진단을 받고 퇴원한 환자수는 총 148명이었고, 이 중 남자 71명, 여자 77명이었고, 평균 연령은 42세였다. 1차 기간(1995~1999년)의 원인은 감염질환이 41%, 결체조직 질환 20%, 악성 질환 14%, 기타질환 13%, 원인을 밝히지 못하는 군 13%이었다. 2차 기간 (2000~2005년)에는 감염질환 33%, 결체 조직질환 13%, 악성질환 13%, 기타질환 11%, 원인을 밝히지 못하는 질환 26%이였다. 2차 기간에 통계학적으로 의미있게 진단 되지 않은 군의 빈도가 증가하였으며, 단일질환으로는 림프종, 결핵, 성인형 스틸씨병의 빈도가 높았다. 악성종양 예측인자로는 50세 이상, 혈소판 감소증, 낮은 CRP수치, 비장종대가 있었다. 결론: 최근 진단되지 않은 군의 빈도가 증가하였으나 여전히 감염질환이 불명열의 원인질환으로 가장 많은 비중을 차지 하였고, 단일질환으로는 림프종이 가장 높은 빈도를 차지하고 나쁜 예후를 보여 이에 대한 위험인자가 있는 경우 적극적인 진단적 검사가 필요하다. Background: Fever of unknown origin (FUO) remains a challenging problem despite recent advances in diagnostic modalities. The spectrum of disease causing FUO seems to change with time as well as geographical factors. To evaluate the causes of FUO and identify important trends, a retrospective study was performed. Methods: All adult patients with FUO admitted to the hospital from January 1995 to August 2005 were included. The criteria for diagnosis of FUO were adopted from Durack and Street. Results: A total of 148 patients (mean age, 42.5 years; M:F, 70:78) were enrolled. Of these, 116 (79%) patients were finally diagnosed with one of the following etiologies: infectious disease (37%), connective tissue disorders (16%), malignancy (14%), and miscellaneous disorders (12%) including Kikuchi`s disease, factitious fever, drug-related fever and thyroiditis. Lymphoma (14%) was the most common cause of FUO, followed by tuberculosis (12.8%) and adult-onset Still`s disease (6.8%). An older age (>50 years), thrombocytopenia, lower CRP level and splenomegaly were predictive factors for malignant disease.. However, 31 patients (21%) did not fit a definite diagnosis despite intensive investigation. Moreover, the proportion (26%) of undiagnosed patients during the period of 2000~2005 was significantly higher than that (13%) during the period of 1995~1999 (p<0.044). Conclusions: Although infectious disease remains a major cause of FUO, lymphoma was identified as the most common disease entity. The presence of older age, thrombocytopenia, lower CRP and splenomegaly were predictive of malignant disease and therefore require intensive diagnostic work-up.(Korean J Med 71:302-308, 2006)
증례 : 갑상선기능항진증 환자에서 propylthiouracil 복용 후 발생한 typhlitis 1예
류성열 ( Seong Yeol Ryu ),장영윤 ( Young Yun Jang ),김상윤 ( Sang Yoon Kim ),박근규 ( Keun Gyu Park ),김혜순 ( Hye Soon Kim ) 대한내과학회 2007 대한내과학회지 Vol.73 No.6
Typhlitis은 주로 급성 백혈병으로 항암 치료 후 호중구 감소증 상태에서 발생하는 대장염을 말하는데, 간혹 골수 이식 후 면역억제재 치료 또는 약물에 의한 무과립구증, AIDS, 고형암의 화학요법 후에도 발생할 수 있다. 저자들은 갑상선기능항진증 치료에 사용되는 propylthiouracil을 복용한 후 호중구 감소 상태에서 발생한 Typhlitis 1예를 경험하였으므로 문헌고찰과 함께 보고하는 바이다. 드물지만 갑상선기능항진증 환자에서 propylthiouracil 투여 후 복통, 설사와 발열 등의 증상이 동반되면 typhlitis의 가능성을 고려하여 조기에 적절한 진단과 치료를 하여야 할 것으로 사료된다. Typhlitis is one of the most ominous complications in immunocompromised patients. Neutropenic enterocolitis or typhlitis is a clinical syndrome characterized by fever, diarrhea and abdominal pain that occurs in neutropenic patients. It has been reported as a complication of childhood leukemia, but is now known to occur in adults with solid malignancies, acquired immunodeficiency syndrome (AIDS) or bone marrow transplantation (BMT). The association of typhlitis and propylthiouracil has not been previously reported. We report a case of a 42-year-old female patient with typhlitis due to propylthiouracil patient with hyperthyroidism. (Korean J Med 73:666-669, 2007)
Ryu, Chang Seon,Choi, Young Jae,Nam, Hyo Seon,Jeon, Jang Su,Jung, Taeyoon,Park, Ji-Eun,Choi, Seong-Jin,Lee, Kyuhong,Lee, Moo-Yeol,Kim, Sang Kyum Elsevier 2019 Food and chemical toxicology Vol.125 No.-
<P><B>Abstract</B></P> <P>The present study aimed to determine the effects of cigarette smoke on the regulation of hepatic cytochrome P450 (CYP) and glutathione <I>S</I>-transferase (GST) enzymes in male BALB/c mice exposed to nose-only cigarette smoke for 4 days. There were no significant increases in serum liver injury markers (alanine aminotransferase and aspartate aminotransferase) or oxidative stress (total antioxidant capacity, malondialdehyde, and glutathione disulfide/reduced glutathione) following cigarette smoke exposure, but malondialdehyde was elevated in the bronchoalveolar lavage fluid of smoke-exposed mice. Additionally, the hepatic microsomal protein levels of Cyp1a and Cyp2b, and the activities of ethoxyresorufin <I>O</I>-deethylase, pentoxyresorufin <I>O</I>-depenylase, and chlorzoxazone 6-hydrxylase, were elevated in smoke-exposed mice. Interestingly, the hepatic activities of GST toward 1-chloro-2,4-dinitrobenzene, 1,2-dichloro-4-nitrobenzene, and ethacrynic acid, but not cumene hydroperoxide were enhanced by cigarette smoke exposure, which was consistent with the increased expression levels of mu- and pi-class GSTs, but not alpha-class GSTs, observed in immunoblot analyses. These findings indicate that the short-term inhalation of cigarette smoke induces drug-metabolizing enzymes such as CYP1A, CYP2B, and mu/pi-class GSTs in the absence of hepatic injury and oxidative stress. Furthermore, smoking may alter hepatic drug metabolism, as well as the disposition and toxicity of xenobiotics, including some therapeutic drugs and cigarette smoke constituents.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Hepatotoxicity was not observed in mice exposed to cigarette smoke for 4 days. </LI> <LI> Hepatic protein levels of Cyp1a and Cyp2b were elevated. </LI> <LI> Hepatic activities of EROD, PROD, and chlorzoxazone hydroxylase were elevated. </LI> <LI> Hepatic proteins and mu- and pi-class GST activities were induced. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Ryu Jung-Joo,Das Kallol,Lim Seong-Keun,Hong Soo-Min,Lee Seung-Yeol,Jung Hee-Young 한국균학회 2023 Mycobiology Vol.51 No.2
In this study, a fungal strain KNUF-22-025 belonging to the genus Botryotrichum was isolated from the soil in Korea. The cultural and morphological characteristics of this strain differed from those of closely related species. On malt extract agar, strain KNUF-22-025 showed slower growth than most of the related species, except B. domesticum. The conidia size (9.6–21.1 × 9.9–18.4 µm) of strain KNUF-22-025 was larger than those of B. piluliferum, B. domesticum, and B. peruvianum but smaller than those of B. atrogriseum and B. iranicum. Conidiophores in strain KNUF-22-025 (137 µm) were longer than those in other closely related species but shorter than those in B. atrogriseum. Multi-locus analysis of molecular markers, such as ITS, 28S ribosomal DNA, RBP2, and TUB2 revealed that strain KNUF-22-025 was distinct from other Botryotrichum species. Thus, this strain is proposed as a novel species based on morphological characteristics along with molecular phylogeny and named Botryotrichum luteum sp. nov.