六味地黃湯이 生理活性指標와 淋巴球細胞數에 미치는 影響

金榮權,柳逢夏,朴東源,柳基遠 대한한방종양학회 1998 대한한방종양학회지 Vol.4 No.1

Yookmijihwangtang has been widely used oriental herb prescriptions, which is healing some discuss that come from insufficiency of innate essence and deficiency of kidey Ki. the meaning of healing discusses tonification of insufficient innate essence and insufficient kidney Ki can be regarded as reinforcement of wholely power of keeping homeostasis, that is correlated with immuno-responsibility which protects subject from outer antigen to keep normal vital condition. This study was aimed to investigate correlative effects of Yookmijihw angtang water abstract on the RBC, WBC, blood CD4+ Theler cell count, blood testosterone, blood cAMP and blood cortisol. 40 Sprague-Dawley male rats were divided into 5 groups(Normal, Control, SampleⅠ, SampleⅡ, SampleⅢ), 6 animals in every group. Normal group was not treated anything, control group was administrated normal saline in the same desage of sample Ⅰ. 3 Sample groups were received some of Yookmijihwangrang water abstract at one time per 24 hours during 5 days in different dosage. Sample Ⅰ (1/3 10pack/ml), SampleⅡ (1/62pack/ml), SampleⅢ(1/2.4pack/ml). After finishing treatment, all experimental svbjects were killed for blood sample on RBC, WBC, blood CD4+ T helper cell count, spleen CD4+ T helper cell count, axillary lymph node CD4+ T helper cell count. .blood cAMP, blood testosterone and blood cortisol. The results were as follows: RBC and WBC were incrased in all sample groups. Blood CD4+ Thelper cell count(CD4+ T cell count in the blood/whole lymphocyte count in the blood ×100%) was Mormal 46.17±5.88. Control 44.50±4.37, Sample Ⅰ 53.00±2.28. Sample Ⅱ 53.83±3.87, SampleⅢ 52.17±2.93. By the 95% Duncan ANOVA all experimental groups(sampleⅠ, sampleⅡ, sampleⅢ) showed slight significant difference from Nornal and Control. Blood cAMP(nmd/l) were Normal 1.12±0.17, Control 1.16±0.32, SampleⅠ 0.46±0.07, SampleⅡ 0.44±0.04, SampleⅢ 0.54±0.04 All cxperimental groups were signigicantly different from both Normal and Control groups(p<0.05). Blood cortisol(m l/ml) were Normal 100.00±2.00, Control 90.00±4.00, Samplc Ⅰ 440.00±5.00, SampleⅡ 520.00±40.00, SampleⅢ 470 00±7.00, Blood cortisol of all experimental groups were signifieantly increased(p<0.05). The results suggest that Yookmijihwangiang water abstract could be administrated to patienrts who have some diseases insufficient essence.

소화불량(消化不良)과 과심상(過心傷)의 상관성(相關性)에 대(對)한 고찰(考察) -스트레스, 기울(氣鬱), 비병증(脾病證)의 평가(評價)를 통(通)해-

김진성,윤상협,류봉하,류기원,이상욱,Kim, Jin-Sung,Yoon, Sang-Hyub,Ryu, Bong-Ha,Ryu, Ki-Won,Lee, Sang-Wook 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.4

Background & Object : Dyspepsia for which no organic causes are disclosed is referred to as functional dyspepsia. Functional dyspepsia is here studied in connection with a biopsychosocial model. From the aspect of individual response to external environment, in connection with stress response, functional dyspepsia is studied by both the psychology department and the internal medicine departments. The disease is taken as approachable from the aspect of internal injury due to seven emotions and stress as differentiated by Oriental medicine. Materials and Methods : Targeted at 223 patients underwent medical checks and endoscopy at Kangnam Korean Hospital, Kyunghee University. They agreed to join this clinical experiment. Stress response inventory, GARS (global assessment of recent stress scale), GSRS (gastrointestinal symptom rating scale), diagnostic scores for Ki-depression, and Spleen Disease Differentiation of Syndromes were all measured and evaluated. The test group was comprised of functional dyspepsia patients. The control group was comprised of nonsymptomatic chronic gastritis patients who were found to suffer from chronical gastritis in endoscopy and thus could be diagnosed with functional dyspepsia if symptoms would arise, but did not complain of subjective symptoms. Results showed these corelations: Functional dyspepsia patients were found to have more serious Ki-depression compared to nonsymptomatic chronic gastritis patients. The more serious Ki-depression the more serious the dyspepsia symptoms. The higher the stress response inventory the more serious the dyspepsia. Deficiency of spleen Eum, and Deficiency and Sinking of spleen Gi were found to coincide with serious Ki-depression.

육미지황탕(六味地黃湯)이 생리활성지표(生理活性指標)와 임파구세포수(淋巴球細胞數)에 미치는 영향(影響)

김영권,류봉하,박동원,류기원,Kim, Young-Kuen,Ryu, Bong-Ha,Park, Dong-Won,Ryu, Ki-Won 대한암한의학회 1998 大韓癌韓醫學會誌 Vol.4 No.1

Yookmijihwangtang has been widely used oriental herb prescriptions, which is healing some discuss that come from insufficiency of innate essence and deficiency of kidney Ki. The meaning of healing discusses tonification of insufficient innate essence and insufficient kidney Ki can be regarded as reinforcement of wholely power of keeping homeostasis, that is correlated with immuno-responsibility which protects subject from outer antigen to keep normal vital condition. This study was aimed to investigate correlative effects of Yookmijihwangtang water abstract on the RBC, WBC, blood CD4+ T helper cell count, blood testosterone, blood cAMP and blood cortisol. 40 Sprague-Dawley male rats were divided into 5 groups(Normal, Control, Sample I, Sample II, Sample III), 6 animals in every group. Normal group was not treated anything, control group was administrated normal saline in the same dosage of Sample I. 3 Sample groups were received some of Yookmijihwangtang water abstract at one time per 24 hours during 5 days in different dosage. Sample I(1/310pack/ml), Sample II(1/62pack/ml), Sample III(1/2.4pack/ml). After finishing treatment, all experimental subjects were killed for blood sample on RBC, WBC, blood CD4+ T helper cell count, spleen CD4+ T helper cell count, axillary lymph node CD4+ T helper cell count. blood cAMP, blood testosterone and blood cortisol. The results were as follows; RBC and WBC were increased in all sample groups. Blood CD4+ T helper cell count(CD4+ T cell count in the blood/whole lymphocyte count in the blood ${\times}100%$) was Normal $46.17{\pm}5.88$, Control $44.50{\pm}4.37$, Sample I $53.00{\pm}2.28$, Sample II $53.83{\pm}3.87$, Sample III $52.17{\pm}2.93$. By the 95% Duncan ANOVA all experimental groups(sample I, Sample II, Sample III) showed slight significant difference from Normal and Control. Blood cAMP(nmol/l) were Normal $1.12{\pm}0.17$, Control $1.16{\pm}0.32$, Sample I $0.46{\pm}0.07$, Sample II $0.44{\pm}0.04$, Sample III $0.54{\pm}0.04$. All experimental groups were singificantly different from both Normal and Control groups(p<0.05). Blood cortisol(nl/ml) were Normal $100.00{\pm}2.00$ Control $90.00{\pm}4.00$, Sample I $440.00{\pm}5.00$, Sample II $520.00{\pm}40.00$, Sample III $470.00{\pm}7.00$. Blood cortisol of all experimental groups were significantly increased(p<0.05). The results suggest that Yookmijihwangtang water abstract could be administrated to patients who have some diseases insufficient essence.

수족냉증(手足冷症) 환자(患者)에 대(對)한 컴퓨터 적외선(赤外線) 체열촬영(體熱撮影)의 의의(意義)

조유경,오수완,조남희,김동묵,김진성,류봉하,박동원,류기원,Cho, Yu-Kyung,Oh, Su-Wan,Cho, Nam-Hee,Kim, Dong-Mook,Kim, Jin-Seong,Ryu, Bong-Ha,Park, Dong-Won,Ryu, Ki-Won 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.2

To make a objective diagnosis of the syndrome of cold-limbs, We investigated the 20 patients with cold limbs and GI trouble and 20 normal people as a control group. And we compared the thermal difference between Chon-jung(CV17) and Chung-wan(CV12 中脘), Chon-jung(CV17) and Ki-hae(氣海 CV6) and we compared the thermal differences of No-gung(PE8 勞宮) and Yong-chon(湧泉 KI1), too. The results were as follows. 1. All 20 patients had GI trouble and cold limbs. They had the symptom-Indigestion(16 cases-80%) with heart burn, tympanites, abdominal distention, hiccup, belching. Beside that symptom they also had constipation(6 cases-30%), diarrhea(3 cases-15%), headache & dizziness(6 cases-30%). And some had the menstrual syndrome, chronic fatigue, palpitation, insomnia, edema, arthralgia. 2. The thermal difference of the palms between the patients group and the control group were $25.70^{\circ}C,\;25.82^{\circ}C$, but they were not significant. 3. The thermal difference of the soles between the patients group and the control group were $23.58^{\circ}C,\;24.42^{\circ}C$ and the significancy was P=0.020 so it was significant(P<0.05). 4. The thermal difference of the palms and Chon-jung(CV17) between the patients group and the control group were $1.08^{\circ}C,\;0.76^{\circ}C$, but they were not significant. 5. The thermal difference of the sales and Chon-jung(CV17) between the patients group and the control group were $3.01^{\circ}C,\;1.90^{\circ}C$ and the significancy was P=0.003 so it was significant(P<0.05). 6. The thermal difference of Chon-jung(CV17) and Chung-wan(CV12 中脘) between the patients group and the control group was $0.30^{\circ}C,\;0.62^{\circ}C$ and the significancy was P=0.793 so it was significant(P<0.05). 7. The thermal difference of Chon-jung(CV17) and Ki-hae(CV6 氣海) between the patients group and the control group was $0.53^{\circ}C,\;0.68^{\circ}C$, but they were not significant. From the above, I could find the significance of D.I.T.I to diagnose the cold-feet not the cold-hands and the thermal difference between the trunk and limbs was more significant on cold-feet than on cold-hand, either.

Phosphate 유리들의 구조-물성-조성 상관에 대한 연구

류봉기,이승한,이병철 釜山大學校生産技術硏究所 1998 生産技術硏究所論文集 Vol.55 No.-

P₂O -Na₂O-MgO, P₂O-Na₂O 및 P₂O-MgO glass 계에서 조성에 따른 구조변화를 조사하기 위해 glass의 밀도와 물에 대한 안정성 그리고 Raman 과 적외선 흡수 스펙트럼이 측정되었다. 그 결과, P₂O가 60mol% 부근에서 밀도와 물에 대한 안정성의 급격한 증가를 나타내었다. 이러한 변화는 Mg²+ 이온을 중심으로 DBO(double-bonded oxygen)이 배위하면서 glass 구조의 강한 수축을 유발시켜 나타난 구조변화에 기인하는 것으로, Mg²+ 이온을 배위하고 있는 DBO은 이중결합의 성격을 잃어버리고, 다른 하나의 NBO(non-bridging oxygen)과 함께 공명을 일으킨다고 생각된다. Raman, infrared spectroscopy, dnesity, and water resistance in P₂O-Na₂O-MgO, P₂O-Na₂O and P₂O-MgO glass systems were measured to investigate the structural change depending on their composition. The density and water resistance showed an abrupt increase in the range of about 60mol% P₂O. These results can be explained by the structural changes owing to the strong shrinkage of glass network which is caused by the coordination of DBO(double-bonded oxygen) around Mg²+ cations i.e. it seems that the DBOs coordinating Mg²+ cations, losing their characteristics of double bonding, will resonate with other NBOs(non-bridging oxygen).

선삭가공에서 연속형 칩 감지에 關한 硏究

유봉환,사승윤,정창기 崇實大學校 生産技術硏究所 1995 論文集 Vol.25 No.1

Recently progress in metal cutting and machine tool has raised the productivity of cutting operation remakable. Such high productivity, however, has brought troublesome problems on chips, specially, such as continuous chips. Thus manufacturing system can not be automated without controlling the chip forms. Monitoring and diagnosis of various undesirable state in the cutting process are major functions required for the full-automation of manufacturing system. As the computerized monitoring and classifying of the generation of undesirable chips and chip forms which are major obstacle to automation, the algorithm which decide cutting state in this paper.

균열이 없는 균일한 다공질 유리의 특성과 제조

류봉기,이승한,한덕희 釜山大學校生産技術硏究所 1998 生産技術硏究所論文集 Vol.55 No.-

역삼투압, 초여과 공정, 광학 렌즈 등에 응용되는 균열이 없는 다공질 유리를 개발하기 위하여, 붕규산 소다 유리로부터 상분리법 의한 다공질 유리 제조과정에 있어서 분상 열차리 및 용출조건과 조성이 이들 유리의 특성에 미치는 영향을 조사하였다. 균열이 없는 다공질 유리는 높은 silica 함유의 모유리와 낮은 온도 범위(540∼560℃)에서 30h 이상 열처리 후 0.1∼0.3N H₂SO₄ 용액으로 100℃에서 25h 이상 용출시켰을 때 제조 가능하였다. To produce the crack-free porous glass used for the reverse osmosis, hyperfiltration process and optic al lense, porous glass was prepared from the sodium borosilicate parent glass by the phase-separation technique. Effects of heat treatment, leaching condition, and chemical composition in the smaples were investigated. The crack-free porous glass could be fabricated from high-silica parent glass heat-treated at(540∼560℃) for above 30h, then leached with 0.1∼0.3N H₂SO₄solution at 100℃ for above 25h.

[논문] 일본의 나노글라스 기술 동향

류봉기 부산대학교 생산기술연구소 2003 生産技術硏究所論文集 Vol.62 No.-

일본의 나노글라스 기술 동향

핵폐기용 실험글라스고화체의 구조 및 특성에 관한 연구

류봉기,박희찬,박성수 釜山大學校生産技術硏究所 1996 生産技術硏究所論文集 Vol.51 No.-

핵연료의 재처리공정중에서 방출되는 high-level방사성폐액을 안정한 글라스형태로 고화하여 처리하는 글라스고화법이 사용되고 있다. 본 연구에서는 고화글라스구성성분의 하나인 Pb가 글라스의 용해도, 글라스중에서의 존재형태, 결정화에 미치는 영향을 UV, XRD, TG등을 이용하여 검토하였다. Pd의 용해도는 Tg∼1200℃에서 수 십-수 백ppm정도이며, 용해도를 전후하여 각각 2가이온 및 콜로이드상태로 존재한다는 것을 확인하였다. 그리고 Pb는 결정화에있어서 결정화를 촉진하였으나, Mn, Cr, V, Sb등의 다원자가원소의 첨가에 의하여 결정화를 억제할 수 있었다. Glass is an attractive form for the permanent and secure disposal treatment of high-level radioactive liquid wastes from high-level nuclear waste re-management process. In present work, we investigated the effect of glass solubility, existing form from of Pd in glass, and crystallization of glass on the Pd behaviour in the waste glass using UV, XRD, and TG. The solubility of Pd was from several 10s to several 100s ppm in Tg∼1200℃, and we found Pd exists as bivalent ionic or colloidal form at around the value of Pd-solubility in glass matrix. In crystallization, Pd in glass was helpful for promoting the crystallization, but Mn, Cr, V, and Sb additives retarded and controlled the crystallization.

반도체 미립자를 함유한 Silica Glass의 제조 및 특성

류봉기,이승한,임재호 釜山大學校生産技術硏究所 1998 生産技術硏究所論文集 Vol.55 No.-

본 연구에서는 Sol-Gel법을 이용하여 우수한 양자 사이즈 효과를 가진 ZnS를 함유한 실리카 유리를 제조하였다. 출발 물질로서 Si(OC₂H)₄와 Zn(CH₃COO)₂·2H₂O를 사용하여 무색 투명한 겔을 제조하였다. 얻어진 겔을 600℃에서 열처리를 하여 상온에서 H₂S gas와 반응시켜 유리 내에 ZnS 미세결정을 형성시켰다. ZnS 미립자의 밴드갭 에너지 3.71∼4.27eV였는데 이 값은 벌크상 ZnS의 밴드갭보다 약 0.1∼0.5eV 더 높은 수치를 나타내었다. ZnS 미세결정의 크기는 EMA(Effective Mass Approximation)에 의해 구하였는데, 이는 ZnO의 투여량과 H₂S gas와의 반응시간에 따라 변화하였다. ZnS 미세결정의 크기가 증가함에 따라, 광흡수단은 낮은 에너지영역으로 이동하였는데, 이 현상은 양자 사이즈 효과를 보여주고 있다. In this study, Sol-Gel process has been applied to make ZnS-doped silica glass having a significant quantum size effect. Si(OC₂H)₄ and Zn(CH₃COO)₂·2H?O were used to prepare transparent and colorless gels. These gels were heated at 600℃, then reacted with H₂S gas to form fine ZnS microcrystals in glasses. The opical band gap of the ZnS microcrystals was 3.71∼4.27eV, which was 0.1∼0.5eV higher than that of bulk ZnS crystal. The size of ZnS microcrystals calculated by EMA(Effective Mass Approximation) in glasses changed with ZnO concentration and H₂S gas reaction time. As the size of the ZnS microcrystal increased, the absorption edge of spectra shifted to the low-energy side, thus providing quantum size effect.