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Raman 分光分析法을 利用한 알킬水銀과 티올 또는 黃化合物과의 相互作用에 관한 硏究
Ryoji Yamamoto(山本良二),Myeong Jin Lee(李明鎭),Jin Suk Kim(金鎭錫),Won Chang Lee(李元暢) 한국예방수의학회 1994 예방수의학회지 Vol.18 No.3
티올(thiol)基나 黃을 含有한 여러 化合物들이 水銀의 毒性을 줄이거나 水銀中毒에 豫防效果가 있음은 여러 硏究者들에 의하여 報告되어 왔다. 그러나 이러한 治療的인 效果가 水銀과 黃化合物들 間의 키레이트作用에 의한 것으로 推定되어 왔을 뿐 化學的 相互作用에 대한 좀더 구체적인 硏究가 이루어지지 못하였다. 著者들은 이런 點에 着眼하여 黃化合物의 水銀中毒에서의 治療作用에 대한 化學的 機轉을 밝혀보고저 試圖하여, 燐酸鹽완충액(0.1M, pH 7.4)으로 만들어진 液體속의 黃化物들과 메틸水銀의 陽이온과의 相互作用을 Laser Raman Spectroscopy에 依하여 調査하였다. 本 實驗의 結果 黃化物中에서 待히 설프히드릴基에 金屬結合의 發生이 높게 나타났으며, 메틸水銀-설프히드릴 또는 黃을 包含한 複合體와의 1 : 1 結合體에서 S-Hg連結位置의 Raman振動數는 약 330cm⁻¹에서 發見되었다. 리간드(ligand)를 變化시킨 振勳數의 전환은 발견되지 않았으며, 相對的인 强度(I S-Hg/ I C-Hg)도 差異가 있었다. 메틸水銀-티올글리세롤(thiolglycerol), 메틸水銀-시스테인(cysteine) 그리고 메틸水銀-메르캅토벤조티아졸(mercaptobenzotiazole : 2MBT)結合部位의 相對的 强度는 각각 0.18, 0.43 그리고 0.62 이었다.
Short-term redistribution of methylmercury by sulfur-containing compounds
Ryoji Yamamoto,Kimiaki Sumino,Katsutoshi Nakamae,Won Chang Lee(李元暢) 한국예방수의학회 1997 예방수의학회지 Vol.21 No.1
16가지의 황함유화합물을 마우스에 급여한 후에 메틸수은(MeHg)의 확산율를 평가하였다. N-2-Mercaptopropionylglycerine (Thiola)와 2,3-dimercaptosuccinic acid (DMSA)는 투여 3시간후에 모든 조직내에 메털수은의 잔류량을 감소시키는데 가장 효과가 있는 것으로 밝혀졌다. Thiota, DMSA 그리고 다른 황함유화합물들과 대조군들은 집락분석법 (集落分析法, cluster analysis)에 의하여 성공적으로 아말감화 되었고, 4가지의 변수에 따라서 4가지의 집락(cluster)로 구분되었다. 집락-I에 속하는 화합물 (D-cysteine과 그외의 것들)과 집락-Ⅲ에 속하는 화합물 (Thiola와 DMSA)은 혈액과 신장내의 메틸수은 농도를 감소시켰다. 집락-Ⅲ에 속하는 화합물 (L-cysteine과 그외의 것들)은 집락-Ⅱ에 속하는 화합물 (glutathione과 그외의 것들)의 효과에 비하여 혈액과 신장에서 각기 119%와 122%까지 메틸수은의 농도가 증가하였다. 모든 조직에서 메틸수은의 감소에 가장 큰 효과를 보인 화합물은 집락-Ⅳ에 속하는 화합물이었고, 그 다음은 집락-I에 속하는 화합물이었다. 메틸수은의 제거에 효과가 없는 화합물은 집락-Ⅱ와 집락-Ⅲ에 속하는 화합물이었다.
Hirozumi Sano,Ryoji Kobayashi,Satoru Matsushima,Daiki Hori,Masato Yanagi,Daisuke Suzuki,Go Ohba,Hiroshi Yamamoto,Kunihiko Kobayashi 대한소아혈액종양학회 2023 Clinical Pediatric Hematology-Oncology Vol.30 No.1
Nephroblastomatosis (NBM) is a precursor of Wilms tumor. We herein report a case in which Wilms tumor was initially suspected and the affected kidney was removed. The tumor was subsequently diagnosed as intralobar NBM and a favorable outcome was achieved with postoperative chemotherapy. A 2-year-old boy who presented with gross hematuria was found to have an enlarged left kidney with hydronephrosis. Needle biopsy of the left kidney suggested Wilms tumor and left nephrectomy was performed. The tumor was histopathologically diagnosed as intralobar NBM. Although NBM is regarded as a precancerous lesion, a definite treatment plan has not yet been established. In the present case, we used a similar chemotherapy regi-men to that for Wilms tumor. Eight years after the completion of chemotherapy, Wilms tumor has not developed or recurred. Appropriate management plans need to be developed by accumulating similar cases.
Nguyen Thi Trang,Takuya Hirai,Tsukasa Yamamoto,Mari Matsuda,Naoko Okumura,Nguyen Thi Huong Giang,Nguyen Thi Lan,Ryoji Yamaguchi 대한수의학회 2014 JOURNAL OF VETERINARY SCIENCE Vol.15 No.3
The objectives of the present study were to evaluate theanatomic localization of porcine reproductive andrespiratory syndrome virus (PRRSV) in naturally infectedpigs and to determine whether oral fluid could be used todetect the virus in infected animals. Two sows, seven2-month-old grower pigs, and 70 6-month-old gilts wereincluded in this study. PRRSV in sera and oral fluid wereidentified by nested reverse transcription PCR (nRT-PCR)while lung, tonsil, and tissue associated with oral cavity weresubjected to nRT-PCR, immunohistochemistry, and in situhybridization. In sows, PRRSV was identified in oral fluidand tonsils. PRRSV was also detected in oral fluid, tonsils,salivary glands, oral mucosa, and lungs of all seven growerpigs. However, viremia was observed in only two growerpigs. Double staining revealed that PRRSV was distributedin macrophages within and adjacent to the tonsillar cryptepithelium. In gilts, the North American type PRRSV fieldstrain was detected 3 to 8 weeks after introducing theseanimals onto the farm. These results confirm previousfindings that PRRSV primarily replicates in tonsils and isthen shed into oral fluid. Therefore, oral fluid sampling maybe effective for the surveillance of PRRSV in breeding herds.
Kazuya Inoki,Seiichiro Abe,Yusaku Tanaka,Koji Yamamoto,Daisuke Hihara,Ryoji Ichijima,Yukihiro Nakatani,Hsin- Yu Chen,Hiroyuki Takamaru,Masau Sekiguchi,Masayoshi Yamada,Taku Sakamoto,Satoru Nonaka,Haru 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.3
Background/Aims: Probe-based confocal laser endomicroscopy (pCLE) requires the administration of intravenous (IV) fluorescein. This study aimed to determine the optimal dose of IV fluorescein for both upper and lower gastrointestinal (GI) tract pCLE. Methods: Patients 20 to 79 years old with gastric high-grade dysplasia (HGD) or colorectal neoplasms (CRNs) were enrolled in thestudy. The dose de-escalation method was employed with five levels. The primary endpoint of the study was the determination ofthe optimal dose of IV fluorescein for pCLE of the GI tract. The reduced dose was determined based on off-line reviews by threeendoscopists. An insufficient dose of fluorescein was defined as the dose of fluorescein with which the pCLE images were notdeemed to be visible. If all three endoscopists determined that the tissue structure was visible, the doses were de-escalated. Results: A total of 12 patients with gastric HGD and 12 patients with CRNs were enrolled in the study. Doses were de-escalated to0.5 mg/kg of fluorescein for both non-neoplastic duodenal and colorectal mucosa. All gastric HGD or CRNs were visible with pCLEwith IV fluorescein at 0.5 mg/kg. Conclusions: In the present study, pCLE with IV fluorescein 0.5 mg/kg was adequate to visualize the magnified structure of both theupper and lower GI tract.