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Dandan Song,Sohaib Shujaat,Ruiting Zhao,Yan Huang,Eman Shaheen,Jeroen Van Dessel,Kaan Orhan,Greetje Vande Velde,Ruxandra Coropciuc,Ruben Pauwels,Constantinus Politis,Reinhilde Jacobs 대한영상치의학회 2020 Imaging Science in Dentistry Vol.50 No.3
Purpose: This study was performed to introduce an in vivo hybrid multimodality technique involving the coregistration of micro-computed tomography (micro-CT) and high-resolution magnetic resonance imaging (HR-MRI) to concomitantly visualize and quantify mineralization and vascularization at follow-up in a rat model. Materials and Methods: Three adult female rats were randomly assigned as test subjects, with 1 rat serving as a control subject. For 20 weeks, the test rats received a weekly intravenous injection of 30 μg/kg zoledronic acid, and the control rat was administered a similar dose of normal saline. Bilateral extraction of the lower first and second molars was performed after 10 weeks. All rats were scanned once every 4 weeks with both micro-CT and HR-MRI. Micro-CT and HR-MRI images were registered and fused in the same 3-dimensional region to quantify blood flow velocity and trabecular bone thickness at T0 (baseline), T4 (4 weeks), T8 (8 weeks), T12 (12 weeks), T16 (16 weeks), and T20 (20 weeks). Histological assessment was the gold standard with which the findings were compared. Results: The histomorphometric images at T20 aligned with the HR-MRI findings, with both test and control rats demonstrating reduced trabecular bone vasculature and blood vessel density. The micro-CT findings were also consistent with the histomorphometric changes, which revealed that the test rats had thicker trabecular bone and smaller marrow spaces than the control rat. Conclusion: The combination of micro-CT and HR-MRI may be considered a powerful non-invasive novel technique for the longitudinal quantification of localized mineralization and vascularization
SRIM simulation of irradiation damage by protons in InAs/GaSb type-II superlattices
Zhou Jing,Hao Ruiting,Pan Xinchang,Ren Yang,Li Junbin,Zhao Jun,Kong Jincheng 한국물리학회 2023 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.82 No.4
With the increasing maturity of material preparation and device process technology, InAs/GaSb type-II superlattices (T2SLs) have become a crucial material system for a new generation of high-performance infrared detectors, which can play a signifcant role in laser detection and satellite remote sensing applications. However, numerous particles such as protons and electrons in the complex space environment are irradiated to produce ionization and displacement damage, making the device’s performance decline and causing work failure. Therefore, in this paper, we employ the Stopping and Range of Ions in Matter (SRIM) to simulate the irradiation damage of protons on InAs/GaSb T2SLs and calculate the vacancy, energy loss, and the nuclear and electronic stopping power. Under diferent energy and irradiation fuences, which harnesses atomic displacements per atom (DPA) to investigate the irradiation damage of protons on InAs/GaSb T2SLs. The results demonstrate that the higher the proton energy, the more concentrated its trajectory in the target material, and the smaller the cross-section of phase interaction with the target material, as well as the smaller energy transferred to the lattice atoms, resulting in a higher concentration of vacancies introduced by low-energy proton irradiation compared with high-energy protons. Meanwhile, the projected range becomes farther and farther, and the DPA slightly diminishes, indicating that the displacement damage is due to proton irradiation and is decreasing with the increase of proton energy.