Neuroprotective effect of miR‑410‑3p against sevoflurane anesthesia‑induced cognitive dysfunction in rats through PI3K/Akt signaling pathway via targeting C–X–C motif chemokine receptor 5

Rui Su,Ping Sun,Dianhong Zhang,Wei Xiao,Chun Feng,Liang Zhong 한국유전학회 2019 Genes & Genomics Vol.41 No.10

Background Postoperative cognitive dysfunction (POCD) is a neurodegenerative disorder with impairment of cognition. Sevoflurane anesthesia has been found to lead to CD and microRNAs (miRNAs) were reported to affect cognitive function. This study investigates the neuroprotective effect against sevoflurane anesthesia-induced CD. Methods HE staining was used to detect the pathological change of hippocampal neuron. Morris water maze test was used to analyze latency time, platform crossing and swimming speed. Quantitative real-time PCR (qRT-PCR) and western blotting were performed to examine the mRNA and protein expression of miR-410-3p, IL-6, TNF-α, IL-1β and C–X–C motif chemokine receptor 5 (CXCR5). Dual-luciferase reporter assay was used to detect the relationship between miR-410-3p and CXCR5. Results MiR-410-3p was downregulated in sevoflurane anesthesia-induced rats and cells and act as a suppressor in sevoflurane anesthesia-induced hippocampal neuron apoptosis and inflammation. Furthermore, miR-410-3p was identified to bind with CXCR5. Further analysis showed that CXCR5 expression was increased by sevoflurane treatment, whereas was repressed by miR-410-3p overexpression. Moreover, miR-410-3p could inhibit sevoflurane anesthesia-induced hippocampal neuron apoptosis by phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway. Conclusion These data indicated that miR-410-3p exhibited its neuroprotective effect on sevoflurane anesthesia-induced CD by targeting CXCR5 via PI3K/Akt signaling pathway. Our study may potentially provide a new light on the pathogenesis and therapeutic method for sevoflurane anesthesia-induced CD.

The conceptual design of grid-connected wind turbine based on speed regulating differential mechanism

Xiaoming Rui,Rui Su,Xin Wu,Qidong Yin 대한기계학회 2014 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.28 No.6

In view of problems arising from the grid-connected wind turbine with the frequency converter, we propose a conceptual design ofgrid-connected wind turbine based on speed regulating differential mechanism (SRDM). The SRDM regulates its output speed andtorque self-adaptively referring to wind rotor and makes the synchronous generator (SG) keep a constant speed to output electricity insteady frequency without the normal frequency converter and it has excellent low voltage ride through (LVRT). This paper offers thekinematics and dynamics analysis of the designed wind turbine and builds the SIMULINK model based on FAST (fatigue, aerodynamics,structures and turbulence) software. The simulation of speed, torque and power of wind rotor under average wind speed of 12 m/s andturbulence intensity of 20% can verify the feasibility of the designed wind turbine.

Quality improvement effects of electrolyzed water on rice noodles prepared with semidry-milled rice flours

Rui Liu,Zhang-Long Yu,Yuan-Lin Sun,Li-Tao Tong,Li-Ya Liu,Li-Li Wang,Xian-Rong Zhou,Su-Mei Zhou 한국식품과학회 2021 Food Science and Biotechnology Vol.30 No.6

To investigate the effects of electrolyzed watertreatment on the qualities of rice noodles prepared withsemidry- milled rice flour, pasting properties and thermalproperties of rice flour, and the cooking and texturalproperties of rice noodles were determined. Higher peakviscosity and lower melting enthalpy were observed inelectrolyzed water (EW) treated rice flour. The hardness,gumminess and chewiness of rice noodle in slightly acidicelectrolyzed water treated rice noodles with availablechlorine concentration (ACC) 20.32 mg/L were increasedsignificantly (p\0.05). The cooking loss decreased significantlyin strong acidic electrolyzed water treated noodleswith ACC 10.09 mg/L treatment (p\0.05). Theresults indicated that EW could promote the gelatinizationof rice flour, and improve the textural qualities of ricenoodles. Therefore EW was appropriate to be used in ricenoodle production.

New technique for strengthening reinforced concrete beams with composite bonding steel plates

Su-hang Yang,Shuang-Yin Cao,Rui-nan Gu 국제구조공학회 2015 Steel and Composite Structures, An International J Vol.19 No.3

Composite bonding steel plate (CBSP) is a newly developed type of structure strengthened technique applicable to the existing RC beam. This composite structure is applicable to strengthening the existing beam bearing high load. The strengthened beam consists of two layers of epoxy bonding prestressed steel plates and the RC beam sandwiched in between. The bonding enclosed and prestressed U-shaped steel jackets are applied at the beam sides. This technique is adopted in case of structures with high longitudinal reinforcing bar ratio and impracticable unloading. The prestress can be generated on the strengthening steel plates and jackets by using the CBSP technique before loading. The test results of full-scale CBSP strengthened beams show that the strength and stiffness are enhanced without reduction of their ductility. It is demonstrated that the strain hysteresis effect can be effectively overcome after prestressing on the steel plates by using such technique. The applied plates and jackets can jointly behave together with the existing beam under the action of epoxy bonding and the mechanical anchorage of the steel jackets. The simplified formulas are proposed to calculate the prestress and the ultimate capacities of strengthened beams. The accuracy of formulas was verified with the experimental results.

Design and Realization of Precise Indoor Localization Mechanism for Wi-Fi Devices

Su, Weideng,Liu, Erwu,Auge, Anna Calveras,Garcia-Villegas, Eduard,Wang, Rui,You, Jiayi Korean Society for Internet Information 2016 KSII Transactions on Internet and Information Syst Vol.10 No.12

Despite the abundant literature in the field, there is still the need to find a time-efficient, highly accurate, easy to deploy and robust localization algorithm for real use. The algorithm only involves minimal human intervention. We propose an enhanced Received Signal Strength Indicator (RSSI) based positioning algorithm for Wi-Fi capable devices, called the Dynamic Weighted Evolution for Location Tracking (DWELT). Due to the multiple phenomena affecting the propagation of radio signals, RSSI measurements show fluctuations that hinder the utilization of straightforward positioning mechanisms from widely known propagation loss models. Instead, DWELT uses data processing of raw RSSI values and applies a weighted posterior-probabilistic evolution for quick convergence of localization and tracking. In this paper, we present the first implementation of DWELT, intended for 1D location (applicable to tunnels or corridors), and the first step towards a more generic implementation. Simulations and experiments show an accuracy of 1m in more than 81% of the cases, and less than 2m in the 95%.

Random vibration analysis of structures by a time-domain explicit formulation method

Su, Cheng,Xu, Rui Techno-Press 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.52 No.2

Non-stationary random vibration of linear structures with uncertain parameters is investigated in this paper. A time-domain explicit formulation method is first presented for dynamic response analysis of deterministic structures subjected to non-stationary random excitations. The method is then employed to predict the random responses of a structure with given values of structural parameters, which are used to fit the conditional expectations of responses with relation to the structural random parameters by the response surface technique. Based on the total expectation theorem, the known conditional expectations are averaged to yield the random responses of stochastic structures as the total expectations. A numerical example involving a frame structure is investigated to illustrate the effectiveness of the present approach by comparison with the power spectrum method and the Monte Carlo simulation method. The proposed method is also applied to non-stationary random seismic analysis of a practical arch bridge with structural uncertainties, indicating the feasibility of the present approach for analysis of complex structures.

Marine (sea) Familiarity Index and Its Influence to National Image

Rui, Dong-Gen,Jung, Yong-Ki,Lee, Chun-Su East Asia Business Economics Association 2019 East asian journal of business management Vol.7 No.3

Purposes - This study discusses various aspects of familiarity with the sea and how familiarity with the sea is perceived. This study also summarizes the literature on the factors of previous researches that affect the formation or decision of national image. Research design and methodology - Sea familiarity index was derived from the results of recognition of free association with the sea, friendliness with the sea, association of the sea with life, interest to the sea, Korea's representative marine regions, and sea related emotionalism. The familiarity with the sea (ocean) perceived by foreign visitors or foreigners in the future will be helpful in deriving a comparative research. Results - This study has identified the marine tourism resources, marine ecology, and the cognitive and emotional situations consumers feel that should be developed practically. If a continuous time series research is conducted in the future through these, it will be a chance to provide a basis for consumers' dynamic awareness. Conclusions - Through this study, it is pointed out that the research utilizing the sea and ocean to form national image highly suggested an opportunity to add and utilize new variables academically. This study on the perspective of the formation of national image suggests a new approach to add and utilize new variables to future research using the sea and ocean.

Naringin and Naringenin Relax Rat Tracheal Smooth by Regulating BKCa Activation

Rui Shi,Jia-Wen Xu,Zi-Ting Xiao,Ruo-Fei Chen,Yi-Lin Zhang,Jia-Bi Lin,Ke-Ling Cheng,Gu-Yi Wei,Pei-Bo Li,Wen-Liang Zhou,Wei-Wei Su 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.9

Naringin and its aglycone, naringenin, occur naturally in our regular diet and traditional Chinese medicines. This study aimed to detect an effective therapeutic approach for cough variant asthma (CVA) through evaluating the relaxant effect of these two bioactive herbal monomers as antitussive and antiasthmatic on rat tracheal smooth muscle. The relaxant effect was determined by measuring muscular tension with a mechanical recording system in rat tracheal rings. Cytosolic Ca2+ concentration was measured using a confocal imaging system in primary cultured tracheal smooth muscle cells. In rat tracheal rings, addition of both naringin and naringenin could concentration dependently relax carbachol (CCh)-evoked tonic contraction. This epithelium-independent relaxation could be suppressed by BaCl2, tetraethylammonium, and iberiotoxin (IbTX), but not by glibenclamide. After stimulating primary cultured tracheal smooth muscle cells by CCh or high KCl, the intracellular Ca2+ increase could be inhibited by both naringin and naringenin, respectively. This reaction was also suppressed by IbTX. These results demonstrate that both naringin and naringenin can relax tracheal smooth muscle through opening big conductance Ca2+-activated K+ channel, which mediates plasma membrane hyperpolarization and reduces Ca2+ influx. Our data indicate a potentially effective therapeutic approach of naringin and naringenin for CVA.

Symposia : Innate Immunity ; Cloning and expression of Tenebrio molitor Gram negative binding protein 1 and novel modular serine protease

( Su Jin Kim ),( Ji Won Park ),( Chan Hee Kim ),( Kyung Baeg Roh ),( Hyeon Hwa Lee ),( Kan Hong Nan ),( Jiang Rui ),( Hyun Mi Kwon ),( Ki Ju Kim ),( Nam Chul Ha ),( Bok Luel Lee ) 한국생화학분자생물학회 (구 한국생화학회) 2007 생화학분자생물학회 춘계학술발표논문집 Vol.2007 No.-

Design and Realization of Precise Indoor Localization Mechanism for Wi-Fi Devices

( Weideng Su ),( Erwu Liu ),( Anna Calveras Auge ),( Eduard Garcia-villegas ),( Rui Wang ),( Jiayi You ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.12

Despite the abundant literature in the field, there is still the need to find a time-efficient, highly accurate, easy to deploy and robust localization algorithm for real use. The algorithm only involves minimal human intervention. We propose an enhanced Received Signal Strength Indicator (RSSI) based positioning algorithm for Wi-Fi capable devices, called the Dynamic Weighted Evolution for Location Tracking (DWELT). Due to the multiple phenomena affecting the propagation of radio signals, RSSI measurements show fluctuations that hinder the utilization of straightforward positioning mechanisms from widely known propagation loss models. Instead, DWELT uses data processing of raw RSSI values and applies a weighted posterior-probabilistic evolution for quick convergence of localization and tracking. In this paper, we present the first implementation of DWELT, intended for 1D location (applicable to tunnels or corridors), and the first step towards a more generic implementation. Simulations and experiments show an accuracy of 1m in more than 81% of the cases, and less than 2m in the 95%.