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Biological Approaches to Treating Intervertebral Disk Degeneration: Devising Stem Cell Therapies
Han, Inbo,Ropper, Alexander E.,Konya, Deniz,Kabatas, Serdar,Toktas, Zafer,Aljuboori, Zaid,Zeng, Xiang,Chi, John H.,Zafonte, Ross,Teng, Yang D. Cognizant Communication Corp. 2015 CELL TRANSPLANTATION Vol.24 No.11
Brigatinib versus Crizotinib in <i>ALK</i>-Positive Non-Small-Cell Lung Cancer
Camidge, D. Ross,Kim, Hye Ryun,Ahn, Myung-Ju,Yang, James Chih-Hsin,Han, Ji-Youn,Lee, Jong-Seok,Hochmair, Maximilian J.,Li, Jacky Yu-Chung,Chang, Gee-Chen,Lee, Ki Hyeong,Gridelli, Cesare,Delmonte, Ange New England Journal of Medicine 2018 The New England journal of medicine Vol.379 No.21
Kim, Dong Hun,Han, Seung Ho,Kang, Young-Min,Yang, Daejin,Ross, Caroline A. ELSEVIER SCIENCE 2017 JOURNAL OF ALLOYS AND COMPOUNDS Vol.692 No.-
<P><B>Abstract</B></P> <P>Epitaxial SrFe<SUB>12</SUB>O<SUB>19</SUB> films were prepared on SrTiO<SUB>3</SUB> (001) and (111) substrates by pulsed laser deposition and annealed in air at high temperature. As-deposited and annealed SrFe<SUB>12</SUB>O<SUB>19</SUB> thin films were characterized using scanning electron microscopy, x-ray diffraction, and vibrating sample magnetometry. Films annealed at 800 °C and 1000 °C on (111) substrates showed an epitaxial growth whereas films on (001) substrates grew with both in-plane and out-of-plane c-axis. The magnetic hysteresis loops of annealed films on (111) substrates exhibited a strong magnetocrystalline anisotropy with out-of-plane easy axis originating from epitaxial growth while the films on (001) substrates were almost isotropic.</P> <P><B>Highlights</B></P> <P> <UL> <LI> SrFe<SUB>12</SUB>O<SUB>19</SUB> thin films were grown on SrTiO<SUB>3</SUB> substrates by pulsed laser deposition. </LI> <LI> The as-deposited SrFe<SUB>12</SUB>O<SUB>19</SUB> films exhibited low magnetization with poor crystallinity. </LI> <LI> Annealed SrFe<SUB>12</SUB>O<SUB>19</SUB> films showed crystallites with faceted surfaces. </LI> <LI> Annealed SrFe<SUB>12</SUB>O<SUB>19</SUB> films on SrTiO<SUB>3</SUB> (111) substrate had a strong magnetic anisotropy. </LI> </UL> </P>
Lee, K.U.,Boyd, R.D.,Austic, R.E.,Ross, D.A.,Han, In K. Asian Australasian Association of Animal Productio 1998 Animal Bioscience Vol.11 No.6
Twelve gilts were used to investigate the effect of lysine to protein ratio (5.2 g lysine/100 g CP vs. 6.7 g lysine/100 g CP) in practical diets on nitrogen retention and the efficiency of utilization in growing pigs. Treatments involved 2 levels of dietary lysine (5.2 or 6.7 g/100 g CP) and 3 levels of dietary crude protein (11, 14 and 17% in diet). Nitrogen retention was greatest when pigs were fed the control diet containing 17% protein. Nitrogen retention progressively increased as dietary protein increased (p < 0.01), but it was not affected by lysine concentration (g/100 g CP). Apparent biological value (ABV, nitrogen retained/apparently digestible nitrogen) was estimated to be ~50% at the maximum nitrogen retention. ABV was not affected by lysine concentration, but declined (p < 0.05) as the dietary protein level increased. The efficiency of intake N used for maximum nitrogen retention was approximately 44%. One gram of lysine supported approximately 9 to 10 g apparent protein accretion (nitrogen retention ${\times}$ 6.25/lysine intake) in pigs fed control diets. The efficiency of lysine utilization for protein accretion was lower in pigs fed high-lysine diets (6.7 g lysine/l00 g CP) so that 1 g of lysine accounted for 7 to 8 g of protein accretion in these pigs (p < 0.01). The lysine required to support maximum nitrogen retention in pigs fed high-lysine diets was higher than that in pigs fed control diets, which suggests that lysine was over-fortified relative to crude protein, since practical diets can not be formulated without excess of some amino acids. In summary the concentration of 5.2 g total lysine/100 g CP in diet is more appropriate for corn-soybean diets than the commonly suggested the content of 6.7 g total lysine/100 g CP.
Patterns of Nitrogen Excretion in Growing Pigs
Lee, K.U.,Boyd, R.D.,Austic, R.E.,Ross, D.A.,Han, In K. Asian Australasian Association of Animal Productio 1998 Animal Bioscience Vol.11 No.6
Three crossbred gilts weighing $61{\pm}2kg$ ($mean{\pm}SD$) and three gilts weighing $52{\pm}3kg $ on the day before the first treatment began (d -1) were used for each of two experiments (Exp. 1 and Exp. 2), respectively. In Exp. 1, all pigs were fed the experimental diet (CP 19%) from d -7 to the end of study (d 21) to verify that nitrogen retention is constant during the 21 -d period. In Exp. 2, pigs were fed the control diet (CP 15.5 %) from d -7 to d 8 and then the low-lysine diet from d 9 to d 16 in order to determine how rapidly dietary changes in amino acid composition results in a new equilibrium for nitrogen metabolism. The amount of urine nitrogen loss was not different over 21 days (p > 0.10). Rates of nitrogen retention were not different among pigs (p > 0.10) nor over time (p > 0.10). Average nitrogen retention during the period was 1.00 g/kg $BW^{0.75}$ per day. The apparent biological value was 41%, which did not change over the 3-week period (p > 0.10). The overall efficiency of nitrogen use for nitrogen retention was 35% (Exp. 1). The amount of nitrogen loss in urine and the efficiency of nitrogen utilization for nitrogen gain reached a new equilibrium within 2 to 3 d after the diet was changed. The low-lysine diet resulted in a 20% increase of nitrogen loss in urine (p < 0.001) and a 9% decline in efficiency of nitrogen use for nitrogen retention (p < 0.001). Nitrogen retention while the pigs were fed the control diet was also higher than the retention when pigs were fed the low lysine diet (p < 0.001). The efficiency of nitrogen use for nitrogen retention in pigs fed the control diet was 57% (Exp. 2), which was higher (p < 0.001) than that from pigs fed the low-lysine diets (52%).
Lee, K.U.,Boyd, R.D.,Austic, R.E.,Ross, D.A.,Beermann, D.H.,Han, In K. Asian Australasian Association of Animal Productio 1999 Animal Bioscience Vol.12 No.7
A study was conducted to clarify the impact of recombinant porcine somatotropin (pST) on the efficiency of absorbed nitrogen use for protein deposition in growing pigs. Three levels of dietary crude protein (9.0, 11.5, 14.0% CP) were used. Each had either a sub-optimum or near optimum lysine: CP concentration (Low-lysine, 3.8 g/100 g CP and High-lysine, 5.5 g/100g CP) in order to achieve different metabolic efficiencies for nitrogen deposition (ca. 45 vs. 60%). Twelve crossbred female pigs $(59{\pm}4kg\;BW)$ were placed in metabolism cages and fitted with bladder catheters. Each pig received an excipient injection daily for the first 10-d, a pST (5 mg/d) injection for the second 10-d, and then excipient for the last 10-d. Pigs were randomly assigned to one of six dietary treatments (2 pigs/diet) and fed 4 times per d at $92g/kg\;BW^{0.75}$ $(3{\times}maintenance)$. Means for the excipient period were compared to means for the pST period. Urinary nitrogen (N) output declined in pST-treated pigs (p<0.01) irrespective of dietary protein content or lysine level. Nitrogen retention increased by an average of 11% (p<0.01) with pST treatment (726 vs. $803mg\;N/kg^{0.75}\;BW/d$). Forty-eight percent of the absorbed N was retained with Low-lysine diets, but this increased to 53% with pST injection (+11%, p<0.01). Pigs fed High-lysine diets retained 62% of absorbed N which increased to 69% with pST (+11% p<0.01). the addition of lysine improved N use by 27% (High vs. Low, p<0.01), but the effect of lysine and pST was additive (+40%). Therefore, pST improves N retention and the efficiency of apparently absorbed N use in growing pigs (>60kg). It does so with diets having the potential for either low or high efficiencies of N use (48% and 62%). More work is needed to determine if the partial efficiency of N use improves in direct proportion to pST dose since the improvement in protein deposition is a function of pST dose.
Kim, Yong Su,Jeon, Sang Ho,Bostwick, Aaron,Rotenberg, Eli,Ross, Philip N.,Walter, Andrew L.,Chang, Young Jun,Stamenkovic, Vojislav R.,Markovic, Nenad M.,Noh, Tae Won,Han, Seungwu,Mun, Bongjin Simon The Royal Society of Chemistry 2013 Physical chemistry chemical physics Vol.15 No.43
<P>We report on the chemical adsorption mechanism of atomic oxygen on the Pt(111) surface using angle-resolved-photoemission spectroscopy (ARPES) and density functional calculations. The detailed band structure of Pt(111) from ARPES reveals that most of the bands near the Fermi level are surface-states. By comparing band maps of Pt and O/Pt, we identify that d<SUB><I>xz</I></SUB> (d<SUB><I>yz</I></SUB>) and d<SUB><I>z</I><SUP>2</SUP></SUB> orbitals are strongly correlated in the surface-states around the symmetry point M and K, respectively. Additionally, we demonstrate that the s- or p-orbital of oxygen atoms hybridizes preferentially with the d<SUB><I>xz</I></SUB> (d<SUB><I>yz</I></SUB>) orbital near the M symmetry point. This weak hybridization occurs with minimal charge transfer.</P> <P>Graphic Abstract</P><P>Using ARPES and DFT, the chemical bonding structure of atomic oxygen on the Pt(111) is explored. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cp53376j'> </P>