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Meeting Report: Translational Advances in Cancer Prevention Agent Development Meeting
Mark Steven Miller,Peter J. Allen,Powel H. Brown,Andrew T. Chan,Margie L. Clapper,Roderick H. Dashwood,Shadmehr Demehri,Mary L. Disis,Raymond N. DuBois,Robert J. Glynn,Thomas W. Kensler,Seema A. Khan 대한암예방학회 2021 Journal of cancer prevention Vol.26 No.1
The Division of Cancer Prevention of the National Cancer Institute (NCI) and the Office of Disease Prevention of the National Institutes of Health co-sponsored the Translational Advances in Cancer Prevention Agent Development Meeting on August 27 to 28, 2020. The goals of this meeting were to foster the exchange of ideas and stimulate new collaborative interactions among leading cancer prevention researchers from basic and clinical research; highlight new and emerging trends in immunoprevention and chemoprevention as well as new information from clinical trials; and provide information to the extramural research community on the significant resources available from the NCI to promote prevention agent development and rapid translation to clinical trials. The meeting included two plenary talks and five sessions covering the range from pre-clinical studies with chemo/immunopreventive agents to ongoing cancer prevention clinical trials. In addition, two NCI informational sessions describing contract resources for the preclinical agent development and cooperative grants for the Cancer Prevention Clinical Trials Network were also presented.
Strickman, Daniel,Miller, Mary-E.,Lee, Kwan-Woo,Kim, Heung-Chul,Wirtz, Robert-A.,Perich, Michael,Novakoski, William-L.,Feighner, Brian-H.,Roh, Cheon-Seop 한국곤충학회 2001 Entomological Research Vol.31 No.3
The Republic of Korea (ROK) has been experiencing an expanding epidemic of Plasmodium vivax malaria since 1993, with most cases occurring near the Demilitarized Zone in the northwestern part of the country. During 1996 and 1997, U.S. Army preventive medicine assets undertook a program of surveillance and vector control to reduce transmission to U.S. Forces Korea (USFK). In 1996, the total number of cases was low and only routine vector control (ULV applications of malathion in early evening, availability of repellent for soldiers without command emphasis) was undertaken. Surveillance in 1996 indicated that Anopheles sinensis Wiedemann was the vector and that the risk to unprotected troops was high (1 of 361 mosquitoes infected in one area with 30 bites/person per night, 1 of 1,559 mosquitoes infected in another area with biting rate of 130/person/night). All night collections showed that most biting was occurring late at night, between 2300 and 0300 hrs. Expecting more transmission in 1997, a coordinated program (which did not include chemoprophylaxis) was initiated in which physicians, military commanders, and entomology assets all played a role. The following entomological interventions were concentrated at the site of highest risk, Camp Bonifas: 1) application of residual insecticide to tents, barracks, and bed nets, 2) ULV application of resmethrin late at night, 3) replacement and repair of screens, 4) use of permethrin treated bednets in unscreened billets, and 5) command emphasis on use of repellents and proper wear of the permethrin-treated uniform. Camp Bonifas experienced a 40% decrease in malaria cases (from 5 cases in 1996 to 3 cases in 1997) compared to a 243% increase in other American troops (from 7 to 24 cases) and a 306% increase (from 285 to 1,156 cases) in ROK Army troops. Although more effective use of ULV and application of larvicides would probably have improved the result, we conclude that entomological interventions without chemoprophylaxis reduced malaria transmission at Camp Bonifas by 82% in 1997.
W. Greg Miller,Gary L. Myers,Mary Lou Gantzer,Stephen E. Kahn,E. Ralf Schönbrunner,Linda M. Thienpont,David M. Bunk,Robert H. Christenson,John H. Eckfeldt,Stanley F. Lo,C. Micha Nübling,Catharine M. S 대한진단검사의학회 2012 Laboratory Medicine Online Vol.2 No.1
Results between different clinical laboratory measurement procedures (CLMP) should be equivalent, within clinically meaningful limits, to enable optimal use of clinical guidelines for disease diagnosis and patient management. When laboratory test results are neither standardized nor harmonized, a different numeric result may be obtained for the same clinical sample. Unfortunately, some guidelines are based on test results from a specific laboratory measurement procedure without consideration of the possibility or likelihood of differences between various procedures. When this happens, aggregation of data from different clinical research investigations and development of appropriate clinical practice guidelines will be flawed. A lack of recognition that results are neither standardized nor harmonized may lead to erroneous clinical, financial, regulatory, or technical decisions. Standardization of CLMPs has been accomplished for several measurands for which primary (pure substance) reference materials exist and/or reference measurement procedures (RMPs) have been developed. However, the harmonization of clinical laboratory procedures for measurands that do not have RMPs has been problematic owing to inadequate definition of the measurand, inadequate analytical specificity for the measurand,inadequate attention to the commutability of reference materials, and lack of a systematic approach for harmonization. To address these problems,an infrastructure must be developed to enable a systematic approach for identification and prioritization of measurands to be harmonized on the basis of clinical importance and technical feasibility, and for management of the technical implementation of a harmonization process for a specific measurand.
The use of mobile computing devices in microsurgery
Georgios Pafitanis,Michalis Hadjiandreou,Robert Miller,Katrina Mason,Evgenia Theodorakopoulou,Amir Sadri,Kirsten Taylor,Simon Myers 대한성형외과학회 2019 Archives of Plastic Surgery Vol.46 No.2
Mobile computing devices (MCDs), such as smartphones and tablets, are revolutionizing medical practice. These devices are almost universally available and offer a multitude of capabilities, including online features, streaming capabilities, high-quality cameras, and numerous applications. Within the surgical field, MCDs are increasingly being used for simulations. Microsurgery is an expanding field of surgery that presents unique challenges to both trainees and trainers. Simulation-based training and assessment in microsurgery currently play an integral role in the preparation of trainee surgeons in a safe and informative environment. MCDs address these challenges in a novel way by providing valuable adjuncts to microsurgical training, assessment, and clinical practice through low-cost, effective, and widely accessible solutions. Herein, we present a review of the capabilities, accessibility, and relevance of MCDs for technical skills acquisition, training, and clinical microsurgery practice, and consider the possibility of their wider use in the future of microsurgical training and education.
The use of mobile computing devices in microsurgery
Pafitanis, Georgios,Hadjiandreou, Michalis,Miller, Robert,Mason, Katrina,Theodorakopoulou, Evgenia,Sadri, Amir,Taylor, Kirsten,Myers, Simon Korean Society of Plastic and Reconstructive Surge 2019 Archives of Plastic Surgery Vol.46 No.2
Mobile computing devices (MCDs), such as smartphones and tablets, are revolutionizing medical practice. These devices are almost universally available and offer a multitude of capabilities, including online features, streaming capabilities, high-quality cameras, and numerous applications. Within the surgical field, MCDs are increasingly being used for simulations. Microsurgery is an expanding field of surgery that presents unique challenges to both trainees and trainers. Simulation-based training and assessment in microsurgery currently play an integral role in the preparation of trainee surgeons in a safe and informative environment. MCDs address these challenges in a novel way by providing valuable adjuncts to microsurgical training, assessment, and clinical practice through low-cost, effective, and widely accessible solutions. Herein, we present a review of the capabilities, accessibility, and relevance of MCDs for technical skills acquisition, training, and clinical microsurgery practice, and consider the possibility of their wider use in the future of microsurgical training and education.
해외저술 소개 : 임상 연구: 진단 ; 간세포암종 환자에서 경동맥 화학색전술 후 주 병변(primary index Lesion)의 영상학적 치료 반응 과 임상 경과(초)
( Ahsun Riaz ),( Frank H. Miller ),( Laura M. Kulik ),( Paul Nikolaidis ),( Vahid Yaghmai ),( Robert J. Lewandowski ),( Mary F. Mulcahy ),( Robert K. Ryu ),( Kent T. Sato ),( Ramona Gupta ),( Ed Wang 대한간암연구회 2010 대한간암학회지 Vol.10 No.-
A divergent external loop confers antagonistic activity on floral regulators FT and TFL1
Ahn, Ji Hoon,Miller, David,Winter, Victoria J,Banfield, Mark J,Lee, Jeong Hwan,Yoo, So Yeon,Henz, Stefan R,Brady, Robert Leo,Weigel, Detlef Wiley (John WileySons) 2006 The EMBO journal Vol.25 No.3
<P>The Arabidopsis genes FT and TERMINAL FLOWER1 (TFL1) encode related proteins with similarity to human Raf kinase inhibitor protein. FT, and likely also TFL1, is recruited to the promoters of floral genes through interaction with FD, a bZIP transcription factor. FT, however, induces flowering, while TFL1 represses flowering. Residues responsible for the opposite activities of FT and TFL1 were mapped by examining plants that overexpress chimeric proteins. A region important in vivo localizes to a 14-amino-acid segment that evolves very rapidly in TFL1 orthologs, but is almost invariant in FT orthologs. Crystal structures show that this segment forms an external loop of variable conformation. The only residue unambiguously distinguishing the FT and TFL1 loops makes a hydrogen bond with a residue near the entrance of a potential ligand-binding pocket in TFL1, but not in FT. This pocket is contacted by a C-terminal peptide, which also contributes to the opposite FT and TFL1 activities. In combination, these results identify a molecular surface likely to be recognized by FT- and/or TFL1-specific interactors.</P>