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NPI licensing and the logic of the syntax-semantics interface
Yusuke Kubota,Robert Levine 경희대학교 언어정보연구소 2021 언어연구 Vol.38 No.2
In this paper, we propose an explicit syntax-semantics interface of NPI licensing in Hybrid TLG. Hybrid TLG is a version of categorial grammar that inherits properties of both lexicalist and derivational variants of generative grammar, and it has been shown in our previous research (summarized in Kubota and Levine 2020) that it offers elegant analyses for a number of complex phenomena at the interface of syntax and semantics (especially in the domains of coordination and ellipsis) that turn out to be highly problematic for other grammatical theories. In the present paper, we extend our work to NPI licensing and report on some initial results suggesting that the flexible and systematic architecture of Hybrid TLG turns out to be successful in this domain too. Specifically, our approach captures interactions between NPI licensing (or polarity sensitivity) and other complex phenomena at the syntax-semantics interface including the scopal properties of modal auxiliaries, Gapping, and VP fronting.
Jung-Lim Lee,Robert E. Levin 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.3
Gamma (γ)-irradiation can be used to control pathogens such as Vibrio vulnificus in seafood. The effects of irradiation on microbial cell populations (%) have been studied in order to develop detection methods for irradiated foods. The method used in this study was ethidium bromide monoazide (EMA) real-time polymerase chain reaction (PCR), using V. vulnificus specific primer, EMA, and SYBR<SUP>®</SUP> Green to discriminate between γ-irradiated and non-irradiated cells. Confocal microscope examination showed that γ-irradiation damaged portions of the cell membrane, allowing EMA to penetrate cells of irradidated V. vulnificus. γ-Irradiation at 1.08 KGy resulted in log reduction (?1.15±0.13 log reduction) in genomic targets derived from EMA real-time PCR. The combination cold/heat shock resulted in the highest (?1.74±0.1 log reduction) discrimination of dead irradiated V. vulnificus by EMA real-time PCR.
Amy D. Dobberfuhl,Sara Spettel,Catherine Schuler,Robert M. Levin,Andrew H. Dubin,Elise J.B. De 대한비뇨의학회 2015 Investigative and Clinical Urology Vol.56 No.12
Purpose: Existing data supports a relationship between pelvic floor dysfunction and lower urinary tract symptoms. We developed a survival model of pelvic floor dysfunction in the rabbit and evaluated cystometric (CMG), electromyographic (EMG) and ambulatory voiding behavior. Materials and Methods: Twelve female adult virgin rabbits were housed in metabolic cages to record voiding and defecation. Anesthetized CMG/EMG was performed before and after treatment animals (n=9) received bilateral tetanizing needle stimulation to the pubococcygeous (PC) muscle and controls (n=3) sham needle placement. After 7 days all animals were subjected to tetanizing transvaginal stimulation and CMG/EMG. After 5 days a final CMG/EMG was performed. Results: Of rabbits that underwent needle stimulation 7 of 9 (78%) demonstrated dysfunctional CMG micturition contractions versus 6 of 12 (50%) after transvaginal stimulation. Needle stimulation of the PC musculature resulted in significant changes in: basal CMG pressure, precontraction pressure change, contraction pressure, interval between contractions and postvoid residual; with time to 3rd contraction increased from 38 to 53 minutes (p=0.008 vs. prestimulation). Vaginal noxious stimulation resulted in significant changes in: basal CMG pressure and interval between contractions; with time to 3rd contraction increased from 37 to 46 minutes (p=0.008 vs. prestimulation). Changes in cage parameters were primarily seen after direct needle stimulation. Conclusions: In a majority of animals, tetanizing electrical stimulation of the rabbit pelvic floor resulted in voiding changes suggestive of pelvic floor dysfunction as characterized by a larger bladder capacity, longer interval between contractions and prolonged contraction duration.
Mechanism of Ischemic Mitral Regurgitation
Yutaka Otsuji,Masaaki Takeuchi,Ryuzo Sakata,Robert A. Levine,Chuwa Tei 한국심초음파학회 2008 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.16 No.1
Augmented leaflet tethering due to the outward displacement of the PMs with LV remodeling appears to be a basic mechanism for ischemic MR. Further, annular dilatation and LV dysfunction likely contribute to the development of MR in the presence of augmented tethering. PM dysfunction per se does not usually cause ischemic MR and may occasionally attenuate tethering and MR. The concept of PM dyssynchrony is important and further study to separate effects of PM dyssynchrony from other factors are required. Although surgical annuloplasty is often effective in reversing ischemic MR, the frequency of patients with persistent or recurrent ischemic MR after surgical ring annuloplasty even with advanced down sizing suggests the need for approaches to address tethering. Finally, leaflet tethering in patients with ischemic MR can vary within a single patient and between patients, indicating the multiple and individualized approaches may be required to correct ischemic MR in affected patients. Augmented leaflet tethering due to the outward displacement of the PMs with LV remodeling appears to be a basic mechanism for ischemic MR. Further, annular dilatation and LV dysfunction likely contribute to the development of MR in the presence of augmented tethering. PM dysfunction per se does not usually cause ischemic MR and may occasionally attenuate tethering and MR. The concept of PM dyssynchrony is important and further study to separate effects of PM dyssynchrony from other factors are required. Although surgical annuloplasty is often effective in reversing ischemic MR, the frequency of patients with persistent or recurrent ischemic MR after surgical ring annuloplasty even with advanced down sizing suggests the need for approaches to address tethering. Finally, leaflet tethering in patients with ischemic MR can vary within a single patient and between patients, indicating the multiple and individualized approaches may be required to correct ischemic MR in affected patients.
Amy D. Dobberfuhl,Catherine Schuler,Robert E. Leggett,Elise J.B. De,Robert M. Levin 대한비뇨의학회 2020 Investigative and Clinical Urology Vol.61 No.4
Purpose: To explore the effect of estrogen replacement on pelvic floor and bladder contractile response to electrical field stimulation, following in vitro hypoxia in an animal model of surgical menopause. Materials and Methods: Twelve female adult rabbits were divided into three groups: control, ovariectomy, and ovariectomy with estradiol replacement. At 4 weeks animals were euthanized. Bladder, coccygeus, and pubococcygeus were isolated. Tissues were equilibrated with oxygenated Tyrodes containing glucose and stimulated with electrical field stimulation. Tissues were then stimulated under hypoxic conditions for 1 hour using nitrogenated Tyrodes without glucose. Tissues were then re-oxygenated for 2 hours and stimulated. Results: Pelvic floor required 10 times the stimulation duration (power) to achieve maximum contraction at 2 g baseline tension (10 ms duration) when compared to bladder (1 ms duration). Maximal tension generated was significantly greater for bladder than pelvic floor. Coccygeus and pubococcygeus were significantly less sensitive to the effects of hypoxia and had stable contractile response to field stimulation throughout the hour of hypoxia. Hypoxia resulted in progressive and rapid decline of bladder contractile strength. Following hypoxia, pelvic floor contractile recovery was superior to bladder. Improvement in the contractile response of both bladder and pelvic floor, during the period of post-hypoxia re-oxygenation, was significantly greater in ovariectomy animals treated with estradiol replacement. Conclusions: Replacement of estradiol at time of ovariectomy reduced oxidative stress on tissue and was protective to the effects of hypoxia on pelvic floor and bladder contractile function.