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        2D materials: increscent quantum flatland with immense potential for applications

        Ranjan Pranay,Gaur Snehraj,Yadav Himanshu,Urgunde Ajay B.,Singh Vikas,Patel Avit,Vishwakarma Kusum,Kalirawana Deepak,Gupta Ritu,Kumar Prashant 나노기술연구협의회 2022 Nano Convergence Vol.9 No.26

        Quantum flatland i.e., the family of two dimensional (2D) quantum materials has become increscent and has already encompassed elemental atomic sheets (Xenes), 2D transition metal dichalcogenides (TMDCs), 2D metal nitrides/carbides/carbonitrides (MXenes), 2D metal oxides, 2D metal phosphides, 2D metal halides, 2D mixed oxides, etc. and still new members are being explored. Owing to the occurrence of various structural phases of each 2D material and each exhibiting a unique electronic structure; bestows distinct physical and chemical properties. In the early years, world record electronic mobility and fractional quantum Hall effect of graphene attracted attention. Thanks to excellent electronic mobility, and extreme sensitivity of their electronic structures towards the adjacent environment, 2D materials have been employed as various ultrafast precision sensors such as gas/fire/light/strain sensors and in trace-level molecular detectors and disease diagnosis. 2D materials, their doped versions, and their hetero layers and hybrids have been successfully employed in electronic/photonic/optoelectronic/spintronic and straintronic chips. In recent times, quantum behavior such as the existence of a superconducting phase in moiré hetero layers, the feasibility of hyperbolic photonic metamaterials, mechanical metamaterials with negative Poisson ratio, and potential usage in second/third harmonic generation and electromagnetic shields, etc. have raised the expectations further. High surface area, excellent young’s moduli, and anchoring/coupling capability bolster hopes for their usage as nanofillers in polymers, glass, and soft metals. Even though lab-scale demonstrations have been showcased, large-scale applications such as solar cells, LEDs, flat panel displays, hybrid energy storage, catalysis (including water splitting and CO2 reduction), etc. will catch up. While new members of the flatland family will be invented, new methods of large-scale synthesis of defect-free crystals will be explored and novel applications will emerge, it is expected. Achieving a high level of in-plane doping in 2D materials without adding defects is a challenge to work on. Development of understanding of inter-layer coupling and its effects on electron injection/excited state electron transfer at the 2D-2D interfaces will lead to future generation heterolayer devices and sensors.

      • Evaluation of Pulmonary Nodule in Mantle Cell Lymphoma

        ( Amar Ranjan ),( Harshita Dubey ),( Pranay Tanwar ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.0

        Introduction Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin lymphoma (NHL) with median survival 3 -4 years from diagnosis. Method A case was retrieved from Hospital Record. Short Clinical History A 64 year old male presented with generalized lymphadenopathy. Hemogram showed TLC 12200/ cmm with 70% lymphoid cells in blood smear. Bone marrow (BM) aspirate smear showed 70% abnormal lymphoid cells, which was supported by biopsy (CD20+, CD3-). Viral markers were negative. Lymph node biopsy showed lymphoid cell positive for CD20, CD5 & Cyclin D and negative for CD3 & CD23; indicating MCL. Management with 6 # Bendamustine & Rutiximab resulted into clinical and hematological improvement. After 17 months of treatment free interval (TFI), he presented with Peripheral Neuropathy Grade -III, with no hematological or radiological abnormality. Pregabalin was advised. Again after 2 months (19 months of TFI) he presented with left inguinal lymphadenopathy. Biopsy from lymph node as well as BM showed abnormal lymphoid cells positive for CD20, CD5 & Cyclin D and negative for CD3, CD23, CD10 & BCL-6, MCL relapse was suggested. After 3 # CHOP type II Diabetes was detected. After 6 # CHOP chemotoxicity like fever, cough, vomiting, mucositis, oral ulcer etc. were noticed, which were managed conservatively along with Linalidomide and Prednisolone. Follow up x-ray & HRCT showed nodular lesions in right upper/ mid lobe; therapy for pulmonary Tuberculosis was started. Later he presented with painless and gradually increasing swelling in left thigh, for which radiotherapy showed partial relief. Doppler study for the cause of thigh swelling suggested a partial thrombus in left proximal Great saphanous vein, Lenalidomide induced Dddep vein thrombosis was considered, which was managed with anticoagulants. The case expired after some days. Conclusion Relapsed MCL cases are prone to develop Tuberculosis in developing countries leading to death.

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        A systematic review of clinical and laboratory parameters of 3,000 COVID-19 cases

        ( Harsh Goel ),( Ishan Gupta ),( Mbbs-student ),( Meenakshi Mourya ),( Sukhdeep Gill ),( Anita Chopra ),( Amar Ranjan ),( Goura Kishor Rath ),( Pranay Tanwar ) 대한산부인과학회 2021 Obstetrics & Gynecology Science Vol.64 No.2

        The coronavirus disease 2019 (COVID-19) has spread worldwide. It is still a pandemic and poses major health problem across the globe. In our review, clinical characteristics and laboratory parameters of COVID-19 patients were compiled systematically, with special reference to pregnant women in order to understand the disease course. An extensive literature search on various scientific databases for relevant manuscripts was conducted, which yielded 7 manuscripts for final analysis. The most common symptoms were fever (85%), cough (70.63%), chest tightness (37.36%), expectoration (33.27%), fatigue (32%), dyspnea (31.95%), and shortness of breath (31.19%), while hemoptysis (1.0%) was the least common. The associated comorbidities were hypertension (21.6%) and diabetes (10.0%). In terms of hematological parameters, lower total leukocyte counts were observed in 65% of cases and biochemical parameters, patients demonstrated elevated levels of albumin (53.72%), lactate dehydrogenase (45.71%), and natriuretic peptide (34.84%); however, total bilirubin was elevated in only 8% of cases. In the acute inflammatory cytokine profile, C-reactive protein (59.0%), tumor necrosis factor (58.0%), erythrocyte sedimentation rate (57.0%), interleukin-2 (IL- 2, 54.0%), and IL-6 (52.0%) levels were increased, while prolactin levels (6.5%) were minimally elevated. The recovery rate was approximately 41%, and mortality was about 6.5%. The study also concluded that the clinical symptoms of COVID-19 were similar among pregnant and non-pregnant women. There was no evidence of vertical transmission of COVID-19 infection. This review critically analyzed COVID-19 as a public health hazard in order to help policy makers, health care givers, and primary physicians to promote early diagnosis and prevention.

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