Strain-rate effects on interaction between Mode I matrix crack and inclined elliptic inclusion under dynamic loadings

Ying Li,Wan-Chao Qiu,Zhuo-Cheng Ou,Zhuo-Ping Duan,Feng-Lei Huang 국제구조공학회 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.44 No.6

The strain rate effects on the interaction between a Mode I matrix crack and an inclined elliptic matrix-inclusion interface under dynamic tensile loadings were investigated numerically, and the results are in agreement with previous experimental data. It is found, for a given material system, that there are the first and the second critical strain rates, by which three kinds of the subsequent crack growth patterns can be classified in turn with the increasing strain rate, namely, the crack deflection, the double crack mode and the perpendicular crack penetration. Moreover, such a crack deflection/penetration behavior is found to be dependent on the relative interfacial strength, the inclined angle and the inclusion size. In addition, it is shown that the so-called strain rate effect on the dynamic strength of granule composites can be induced directly from the structural dynamic response of materials, not be entirely an intrinsic material property.

Comparison of Oncoplastic Breast-Conserving Surgery and Breast- Conserving Surgery Alone: A Meta-Analysis

Jun-Ying Chen,Yi-Jie Huang,Liu-Lu Zhang,Ci-Qiu Yang,Kun Wang 한국유방암학회 2018 Journal of breast cancer Vol.21 No.3

Purpose: The use of oncoplastic reconstruction for breastconserving surgery (BCS) extends benefits beyond merely minimizing poor cosmetic results. However, the feasibility and oncological safety of oncoplastic surgery (OPS) are controversial. Methods: This meta-analysis aimed to compare the short-term and long-term oncological outcomes of BCS alone and BCS plus OPS. Relevant studies published before July 2017 in the Embase, the Cochrane Library, PubMed, and Web of Science databases were screened and collected. The meta-analysis was performed using STATA software (Stata Corp.). Results: A total of 3,789 patients from 11 studies were included, with 2,691 patients in the BCS-alone group and 1,098 patients in the BCS plus OPS group. The demographics were similar between both groups, and no significant difference was observed in pathological T and N stages between the two groups. Re-excision was less common (relative risk [RR], 0.66; p=0.009) and the positive-margin rate was lower, but not significantly (RR, 0.83; p=0.191), in the BCS plus OPS group than in the BCS-alone group. The local and distal recurrence rates were similar in both groups. Both disease-free survival (hazard ratio [HR], 1.19; 95% confidence interval [CI], 0.96– 1.49; p=0.112) and overall survival (HR, 1.14; 95% CI, 0.76– 1.69; p=0.527) did not differ between the two groups. Conclusion: A combination of BCS and OPS is preferred over BCS alone for decreasing re-excisions and provides similar long-term survival as BCS alone in patients with breast cancer.

Strain-rate effects on interaction between Mode I matrix crack and inclined elliptic inclusion under dynamic loadings

Li, Ying,Qiu, Wan-Chao,Ou, Zhuo-Cheng,Duan, Zhuo-Ping,Huang, Feng-Lei Techno-Press 2012 Structural Engineering and Mechanics, An Int'l Jou Vol.44 No.6

The strain rate effects on the interaction between a Mode I matrix crack and an inclined elliptic matrix-inclusion interface under dynamic tensile loadings were investigated numerically, and the results are in agreement with previous experimental data. It is found, for a given material system, that there are the first and the second critical strain rates, by which three kinds of the subsequent crack growth patterns can be classified in turn with the increasing strain rate, namely, the crack deflection, the double crack mode and the perpendicular crack penetration. Moreover, such a crack deflection/penetration behavior is found to be dependent on the relative interfacial strength, the inclined angle and the inclusion size. In addition, it is shown that the so-called strain rate effect on the dynamic strength of granule composites can be induced directly from the structural dynamic response of materials, not be entirely an intrinsic material property.

Combined experimental and computational investigation of the cavitating flow in an orifice plate with special emphasis on surrogate-based optimization method

Xianlin Li,Biao Huang,Tairan Chen,Ying Liu,Sicong Qiu,Jing Zhao 대한기계학회 2017 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.31 No.1

We investigated the influence of geometrical parameters of the orifice plate on the cavitation structures, and optimized these parameters by using a surrogate-based model with special emphasis on the concentration of hydroxyl radical released. The results show that for the orifice plate of the hydrodynamic cavitation system, the possible location of the inception of the cavity spreads to throat and divergent section of the venturi geometry. Based on the surrogate model and global sensitivity assessment, the diameter of throat D t and diameter of inlet D in significantly influenced the size of the cavity, while the length of throat L t had little effect on both cavitation intensity and flow rate. It should be noted that when L t is decreased, the size of cavity would be slightly decreased but the flow rate increased clearly. The increase of the diverging section is in favor of the size of cavity. By comparing the experimental measurements on the concentration of Methylene blue, the optimum geometry of the orifice plate for best cavitational activity is proposed.

Functional Investigation on Aromatase in Endometrial Hyperplasia in Polycystic Ovary Syndrome Cases

Zhao, Pan-Lin,Zhang, Qiu-Fang,Yan, Li-Ying,Huang, Shuo,Chen, Yuan,Qiao, Jie Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20

Objective: To explore the possible significance of aromatase P450 in endometrial hyperplasia with a background of polycystic ovary syndrome (PCOS). Methods: Immunohistochemistry was used to determine the expression of aromatase P450 in endometrium of PCOS patients. Semiquantitative analysis of aromatase P450 expression of mRNA and protein level wasalso carried out by real-time quantitative RT-PCR method. After endometrial cells were stimulated by testosterone and letrozole in vitro, the estradiol ($E_2$) level was determined, and the expression of cell aromatase P450 mRNA was assessed. Results: The aromatase P450 mRNA level was increased in endometria of PCOS patients. When endometrial cells were cultured with $10^{-6}M$ testosterone, the $E_2$ level in the culture medium increased. An inhibitory effect on $E_2$ generation and expression of aromatase P450 mRNA was observed when the endometrial cells were treated with $10^{-5}M$ letrozole. Conclusions: There is an increased expression of aromatase P450 in PCOS patient endometrium. Androgen stimulation could enhance the synthesis of aromatase P450 mRNA and the production of $E_2$ in endometrial cells in vitro while letrozole could do the reverse.

Genome-wide association study for loin muscle area of commercial crossbred pigs

Luan Menghao,Ruan Donglin,Qiu Yibin,Ye Yong,Zhou Shenping,Yang Jifei,Sun Ying,Ma Fucai,Wu Zhenfang,Yang Jie,Yang Ming,Zheng Enqin,Cai Gengyuan,Huang Sixiu 아세아·태평양축산학회 2023 Animal Bioscience Vol.36 No.6

Objective: Loin muscle area (LMA) is an important target trait of pig breeding. This study aimed to identify single nucleotide polymorphisms (SNPs) and genes associated with LMA in the Duroc×(Landrace×Yorkshire) crossbred pigs (DLY). Methods: A genome-wide association study was performed using the Illumina 50K chip to map the genetic marker and genes associated with LMA in 511 DLY pigs (255 boars and 256 sows). Results: After quality control, we detected 35,426 SNPs, including six SNPs significantly associated with LMA in pigs, with MARC0094338 and ASGA0072817 being the two key SNPs responsible for 1.77% and 2.48% of the phenotypic variance of LMA, respectively. Based on previous research, we determined two candidate genes (growth hormone receptor [GHR] and 3-oxoacid Co A-transferase 1 [OXCT1]) that are associated with fat deposition and muscle growth and found further additional genes (MYOCD, ARHGAP44, ELAC2, MAP2K4, FBXO4, FBLL1, RARS1, SLIT3, and RANK3) that are presumed to have an effect on LMA. Conclusion: This study contributes to the identification of the mutation that underlies quantitative trait loci associated with LMA and to future pig breeding programs based on marker-assisted selection. Further studies are needed to elucidate the role of the identified candidate genes in the physiological processes involved in LMA regulation.

Influence of green light illumination on several enzymes involved in energy metabolism in the oriental armyworm, Mythimna separata (Lepidoptera: Noctuidae)

김길남,신운철,윤철남,송혜승,Zhi-Juan Huang,Qiu-Ying Huang,Chaoliang Lei 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.2

The oriental armyworm, Mythimna separata Walker, is an important insect pest in eastern Asia. Green (520 nm) light with an exposure time of > 30 min can result in a stronger phototactic response than the wavelengths of other lights in M. separata moths. The present study was mainly focused to estimate the activities of several enzymes (such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH), glycerol-3-phosphate dehydrogenase (GPDH), lactate dehydrogenase (LDH) and 3-hydroxyacyl-CoA dehydrogenase (HOAD)) involved in the energy metabolism and a ratio of HOAD to GAPDH activity in M. separata moths exposed to the green light for different exposure times. Our results showed that when M. separata moths were exposed to the green light for 30 min, the activities of the two enzymes (GPDH and HOAD) and as well as the ratio of HOAD to GAPDH activity were significantly elevated. The activity of LDH was significantly increased in the moths exposed for 60 min. Furthermore, significant differences in enzyme activities between the male and female moths were recorded in 45 min exposure time group of the GAPDH, all light treatment groups of the LDH, and 45 min group of the ratio of HOAD to GAPDH activity, respectively. We suggest that when M. separata adult moths are exposed to the green light, these enzymes can be activated to produce energy for starting the phototactic behavior to the green light. Our findings may provide a theoretical basis for elucidating a reason of the phototactic behavior of nocturnal moths.

The P275A Polymorphism in the Macrophage Scavenger Receptor 1 Gene and Prostate Cancer Risk: a Meta-Analysis

Zhou, Qiao-Xia,Tang, Jian-Qiu,Zhao, Fen,Wei, Fu-Lin,Huang, Ying Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.13

Background: Published data regarding associations between the P275A polymorphism in the macrophage scavenger receptor 1 (MSR1) gene and prostate cancer (PCa) risk are inconclusive. The aim of this study was to comprehensively evaluate the genetic risk of P275A polymorphism in MSR1 gene for PCa. Materials and Methods: A systematic literature search was carried out in Pubmed, Medline (Ovid), Embase, CBM, CNKI, Weipu, and Wanfang databases, covering all available publications (last search was performed on Apr 27, 2015). Statistical analysis was performed using Revman 5.2 and STATA 10.1 software. Results: A total of 5,017 cases and 4,869 controls in 12 case-control studies were included in this meta-analysis. When all groups were pooled, there was no evidence that the P275A polymorphism had a significant association with PCa under dominant (OR=0.93, 95%CI=0.81-1.06, and p=0.28), co-dominant (homogeneous OR=0.97, 95%CI=0.56-1.68, and p=0.92; heterogeneous OR=0.93, 95%CI=0.74-1.15, and p=0.49), recessive (OR=1.10, 95%CI=0.65-1.87, and p=0.73), over-dominant (OR=0.93, 95%CI=0.75-1.15, and p=0.50), and allelic (OR=0.95, 95%CI=0.77-1.16, and p=0.61) genetic models. For stratified analyses by ethnicity and study design, no significant associations were found in the white race, the yellow race, the black race and mixed ethnicity, and the population-based case-control (PCC) and hospital-based case-control (HCC) studies under all genetic models. Conclusions: Based on our meta-analysis, the P275A polymorphism in the MSR1 gene is unlikely to be a risk factor for PCa.

Comparison of Hybridization Behavior between Double and Single Strand of Targets and the Application of Asymmetric PCR Targets in cDNA Microarray

( Qing Wei ),( San Zhen Liu ),( Jian Feng Huang ),( Xue Ying Mao ),( Xiao Hui Chu ),( Yu Wang ),( Min Yan Qiu ),( Yu Min Mao ),( Yi Xie ),( Yao Li ) 생화학분자생물학회 2004 BMB Reports Vol.37 No.4

Double stranded targets on the cDNA microarray contain representatives of both the coding and noncoding strands, which will introduce hybridization competition with probes. Here, the effect of double and single strands of targets on the signal intensity and the ratios of Cy5/Cy3 within the same slide were compared. The results show that single stranded targets can increase the hybridization efficiency without changing the Cy5/Cy3 ratio. Based on these results, a new strategy was established by generating cDNA targets with asymmetric PCR, instead of conventional PCR, to increase the sensitivity of the cDNA microarray. Furthermore, the feasibility of this approach was validated. The results indicate that the cDNA microarray system based on asymmetric PCR is more sensitive, with no decrease in the reliability and reproducibility as compared with that based on conventional symmetric PCR.

High-Performance Self-Expanding NiTi Stents Manufactured by Laser Powder Bed Fusion

Xiang Li,Shijie Hao,Baopeng Du,Bo Feng,Haohang Li,Ping Qiu,Bingmin Huang,Lishan Cui,Ying Yang 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.5

Laser powder bed fusion (LPBF) is a promising technology for the manufacturing of customized medical implants, due tothe intrinsic potential in the fabrication of components with complex geometries. However, for the LPBF-produced vascularimplants, the dimensional accuracy, forming quality and surface finish are still unable to satisfy the medical requirements. This work provides a systematic study on dimensional accuracy control, relative density, surface polishing, shape memoryfunction, superelasticity property and deployment capability of LPBF-produced self-expanding NiTi stents, aiming at promotingtheir application in the biomedical field. The dimensional deviation of stent struts between designed prototype andas-melted products is reduced to 3% by applying laser beam compensation (LBC) strategy. Meanwhile, the study reveals thatthe LBC parameters have strong influence on the relative density of NiTi stents. 99.89% of relative density is achieved forLPBF-produced NiTi stent as the LBC value is optimized to 120 μm. The incompletely melted powders, balling and rippingstructures on the surface of NiTi stents are observed to exhibit different removal processes during electrochemical polishing. The surface roughness (Ra) of NiTi stent is decreased from 7.17 μm for as-melted stent to 0.34 μm for as-polished one. Basedon high relative density and surface quality, the stents exhibit excellent shape memory function and superelasticity propertyin the process of cyclic deformation. Finally, the deployment capability of the stents is assessed. The results confirm thatLPBF-produced NiTi stents can be successfully crimped and released during the deployment process.