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Qianqian Dong,Chengwang Xiong,Chunlei Ma,Huajian Wei 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.6
Extensive efforts have been made in the understanding of the failure characteristics of straight fissure, but the failure patterns of rock mass with intermittent non-straight fissures have not been examined comprehensively. To address this problem, the present study investigated the cracking behaviors of natural marble specimens containing double S-shaped fissures under compression. Seven types of coalescence patterns for S-shaped fissures are classified, two of which are firstly reported and featured by the occurrence of the self-coalescence phenomenon. It is found that the decrease of strength is accompanied by the internal crack at the stage of crack growth and propagation, following the occurrence of the external crack, at relatively large flaw and ligament angle. The numerical simulations with the corresponding parameters were carried out for comparison. This research provides helpful information for understanding the failure modes induced by crack propagation of intermittent double S-shaped fissures.
Spinal Cord Injury: How Could Acupuncture Help?
Qianqian Fan,Omer Cavus,Lize Xiong,Yun Xia 사단법인약침학회 2018 Journal of Acupuncture & Meridian Studies Vol.11 No.4
Spinal cord injury (SCI) is one of the most common causes of death and disability worldwide, and it can result in both permanent disability and serial complications in patients. Research shows that patients with SCI complications are often interested in acupuncture for symptomatic relief. Therefore, the issue of physicians advising their patients regarding the use of acupuncture to alleviate SCI complications becomes pertinent. We review and summarize two types of relevant publications: (1) literature concerning acupuncture for SCI and its complications and (2) underlying mechanisms of acupuncture therapy for SCI. Clinical trials and reviews have suggested that acupuncture effectively manages a range of post-SCI complications, including motor and sensory dysfunction, pain, neurogenic bowel and bladder, pressure ulcers, spasticity, and osteoporosis. The effect of acupuncture on post-SCI orthostatic hypotension and sexual dysfunction remains unclear. Decreased oxidative stress, inhibition of inflammation and neuronal apoptosis, regulation of the expression and activity of endogenous biological mediators, and increased regenerative stem cell production are the possible mechanisms of acupuncture therapy for SCI. Although many limitations have been reported in previous studies, given the evidence for the efficacy of acupuncture, we recommend that physicians should support the use of acupuncture therapy for SCI complications.
Chuqian Lei,Ciqiu Yang,Bin Xia,Fei Ji,Yi Zhang,Hongfei Gao,Qianqian Xiong,Yufeng Lin,Xiaosheng Zhuang,Liulu Zhang,Teng Zhu,Minyi Cheng,Mei Yang,Kun Wang 한국유방암학회 2020 Journal of breast cancer Vol.23 No.1
Purpose: Tau is a microtubule-associated protein that can be found in both normal and abnormal breast cells. Whether the expression of Tau protein can predict the response to neoadjuvant chemotherapy (NACT) is still unclear. In this study, we assessed the role of Tau protein expression in predicting a pathological complete response (pCR) to NACT for different subtypes of breast cancer. Methods: Four hundred and sixty-eight eligible patients were retrospectively recruited in our study. The relationship between clinicopathologic factors, including Tau protein expression, and pCR in different subtypes was evaluated using logistic regression analysis. Correlation between Tau and disease-free survival (DFS) and overall survival (OS) was performed using Kaplan–Meier analysis. Results: The expression of Tau protein was negatively correlated with pCR, especially in triple-negative breast cancer (TNBC). No significant difference was observed in the luminal human epidermal growth factor receptor-2 (HER2)-negative subtype and HER2-positive subtype. Patients with pCR were associated with better DFS and OS (p < 0.05). However, Tau protein expression had no association with either DFS or OS (p > 0.05). Conclusion: Tau protein expression can predict pCR before NACT in TNBC, but there was no correlation between Tau expression and DFS or OS.