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Chuqian Lei,Ciqiu Yang,Bin Xia,Fei Ji,Yi Zhang,Hongfei Gao,Qianqian Xiong,Yufeng Lin,Xiaosheng Zhuang,Liulu Zhang,Teng Zhu,Minyi Cheng,Mei Yang,Kun Wang 한국유방암학회 2020 Journal of breast cancer Vol.23 No.1
Purpose: Tau is a microtubule-associated protein that can be found in both normal and abnormal breast cells. Whether the expression of Tau protein can predict the response to neoadjuvant chemotherapy (NACT) is still unclear. In this study, we assessed the role of Tau protein expression in predicting a pathological complete response (pCR) to NACT for different subtypes of breast cancer. Methods: Four hundred and sixty-eight eligible patients were retrospectively recruited in our study. The relationship between clinicopathologic factors, including Tau protein expression, and pCR in different subtypes was evaluated using logistic regression analysis. Correlation between Tau and disease-free survival (DFS) and overall survival (OS) was performed using Kaplan–Meier analysis. Results: The expression of Tau protein was negatively correlated with pCR, especially in triple-negative breast cancer (TNBC). No significant difference was observed in the luminal human epidermal growth factor receptor-2 (HER2)-negative subtype and HER2-positive subtype. Patients with pCR were associated with better DFS and OS (p < 0.05). However, Tau protein expression had no association with either DFS or OS (p > 0.05). Conclusion: Tau protein expression can predict pCR before NACT in TNBC, but there was no correlation between Tau expression and DFS or OS.
Liu, Lu,Ying, Guobing,Wen, Dong,Hu, Cong,Zhang, Chen,Wang, Cheng Techno-Press 2021 Advances in nano research Vol.11 No.3
MXene (Ti<sub>3</sub>C<sub>2</sub>T<sub>x</sub>) reinforced copper matrix composites with weight fractions of MXene from 1 to 4 wt.% were fabricated based on molecular-level and high-shear mixings and spark plasma sintering (SPS) method. The mechanical properties of the composites with different weight fractions of MXene were studied, and X-ray photoelectron spectroscopy (XPS) was used to track the state of MXene in the composite preparation process. Chemical state and interface transitions would result in an interesting ductile-brittle transition phenomenon of the composite. The Vickers hardness and compressive strength of the composites prepared by the molecular-level mixing and high-shear mixing methods have been improved (the maxima are 44.9% and 41.8%, respectively), where the addition of 1wt.% MXene results in a tensile strength increase of 29.9%. The results show that molecular-level mixing and high-shear mixing methods are hopeful to be applied to produce many kinds of MXene composites.