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- 저자 : Qiang Zheng (검색결과 118 건)
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Nonlinear-Dynamic-Analysis Based Fuzzy PID Control Approach for Complex Hydraulic Driving Process
Zheng-Qiang Zhu,Xin-Jiang Lu,Jie Lei,Ming-Hui Huang 한국정밀공학회 2018 International Journal of Precision Engineering and Vol.19 No.7
The strong nonlinearity of the hydraulic driving process for forging makes it difficult to achieve accurate control. In this paper, we propose a nonlinear-dynamic-analysis based Fuzzy PID control approach for this complex process. Unlike the existing control methods that are designed specifically for a given work piece, this proposed control method can be effectively used in the forging of different work pieces. A model of the closed-loop forging system is first derived and a solving method is then developed in order to find the model solution. Using this model solution, the dynamics of the closed-loop forging system is further estimated and the conditions for stability, vibration, and creep, as well as the relationships between the controller parameters and the constraints are also derived. These derived dynamic characteristics, conditions and relationships for different work pieces are further integrated and used to design the controller. Through the use of experiments and simulations on a practical forging system, the effectiveness of all of these analytical results and the designed controller is finally demonstrated.
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Zheng, Qiang,Gong, Tao,Sun, Xun,Zhang, Zhi-Rong The Pharmaceutical Society of Korea 2006 Archives of Pharmacal Research Vol.29 No.12
A triptolide-lysozyme (TP-LZM) conjugate was synthesized to achieve renal specific delivery and to reduce the side effects of triptolide. Triptolide was coupled to lysozyme through succinic via an ester bond with an average coupling degree of 1 mol triptolide per 1 mol lysozyme. The lysozyme can specifically accumulate in the proximal tubular cells of the kidney, making it a potential carrier for targeting drugs to the kidney. The structure of triptolide succinate (TPS) was confirmed by IR, $^{1}H-NMR$, MS and UV. The concentrations of triptolide in various samples were determined by reversed-phase high-performance liquid chromatography (HPLC). In this study, the physicochemical and stability profiles of TP-LZM under various conditions were investgated the stability and releasing profiles of triptolide-lysozyme (TP-LZM) under various conditions. In vitro release trails showed triptolide-lysozyme was relatively stable in plasma (less than 30% of free triptolide released) and could release triptolide quickly in lysosome (more than 80% of free triptolide released) at $37^{\circ}C$ for 24 h. In addition, the biological activities of the conjugate on normal rat kidney proximal tubular cells (NRK52E) were also tested. The conjugate can effectively reduce NO production in the medium of NRK52E induced by lipopolysaccharide (LPS) but with much lower toxicity. These studies suggest the possibility to promote curative effect and reduce its extra-renal toxicity of triptolide by TP-LZM conjugate.
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Qiang Zheng,Tao Gong,Xun Sun,Zhi-Rong Zhang 대한약학회 2006 Archives of Pharmacal Research Vol.29 No.12
A triptolide-lysozyme (TP-LZM) conjugate was synthesized to achieve renal specific delivery and to reduce the side effects of triptolide. Triptolide was coupled to lysozyme through succinic via an ester bond with an average coupling degree of 1 mol triptolide per 1 mol lysozyme. The lysozyme can specifically accumulate in the proximal tubular cells of the kidney, making it a potential carrier for targeting drugs to the kidney. The structure of triptolide succinate (TPS) was confirmed by IR, 1H-NMR, MS and UV. The concentrations of triptolide in various samples were determined by reversed-phase high-performance liquid chromatography (HPLC). In this study, the physicochemical and stability profiles of TP-LZM under various conditions were investgated the stability and releasing profiles of triptolide-lysozyme (TP-LZM) under various conditions. In vitro release trails showed triptolide-lysozyme was relatively stable in plasma (less than 30 % of free triptolide released) and could release triptolide quickly in lysosome (more than 80 % of free triptolide released) at 37oC for 24 h. In addition, the biological activities of the conjugate on normal rat kidney proximal tubular cells (NRK52E) were also tested. The conjugate can effectively reduce NO production in the medium of NRK52E induced by lipopolysaccharide (LPS) but with much lower toxicity. These studies suggest the possibility to promote curative effect and reduce its extra-renal toxicity of triptolide by TP-LZM conjugate.
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Glioma-Associated Oncogene Homolog1 (Gli1)-Aquaporin1 pathway promotes glioma cell metastasis
( Zheng Qiang Liao ),( Ming Ye ),( Pei Gen Yu ),( Chun Xiao ),( Feng Yun Lin ) 생화학분자생물학회(구 한국생화학분자생물학회) 2016 BMB Reports Vol.49 No.7
Glioma-Associated Oncogene Homolog1 (Gli1) is known to be activated in malignant glioma; however, its downstream pathway has not been fully explained. The aim of this study was to explore the role of Gli1-Aquaporin1 (AQP1) signal pathway in glioma cell survival. Our data suggests that both Gli1 and AQP1 are upregulated in glioma tissues, as in comparison to in normal tissues. These up-regulation phenomena were also observed in glioma U251 and U87 cells. It was demonstrated that Gli1 positively regulated the AQP1 expression. By luciferase reporter gene and ChIP assay, we observed that this modulation process was realized by combination of Gli1 with AQP1 promotor. In addition, knock down of Gli1 by siRNA interference reduced the viability of glioma cells as well as suppressed cell metastasis. Also, the inhibitory effects of cell survival by silenced Gli1 were abrogated by AQP1 overexpression. In summary, glioma cell survival is a regulatory process and can be mediated by Gli1-AQP1 pathway. [BMB Reports 2016; 49(7): 394-399]
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Shi, Liang,Chen, Zhan-Guo,Wu, Li-li,Zheng, Jian-Jian,Yang, Jian-Rong,Chen, Xiao-Fei,Chen, Zeng-Qiang,Liu, Cun-Li,Chi, Sheng-Ying,Zheng, Jia-Ying,Huang, Hai-Xia,Lin, Xiang-Yang,Zheng, Fang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23
Many chemotherapeutic agents have been successfully used to treat hepatocellular carcinoma (HCC); however, the development of chemoresistance in liver cancer cells usually results in a relapse and worsening of prognosis. It has been demonstrated that DNA methylation and histone modification play crucial roles in chemotherapy resistance. Currently, extensive research has shown that there is another potential mechanism of gene expression control, which is mediated through the function of short noncoding RNAs, especially for microRNAs (miRNAs), but little is known about their roles in cancer cell drug resistance. In present study, by taking advantage of miRNA effects on the resistance of human hepatocellular carcinoma cells line to cisplatin, it has been demonstrated that miR-340 were significantly downregulated whereas Nrf2 was upregulated in HepG2/CDDP (cisplatin) cells, compared with parental HepG2 cells. Bioinformatics analysis and luciferase assays of Nrf2-3'-untranslated region-based reporter constructor indicated that Nrf2 was the direct target gene of miR-340, miR-340 mimics suppressing Nrf2-dependent antioxidant pathway and enhancing the sensitivity of HepG2/CDDP cells to cisplatin. Interestingly, transfection with miR-340 mimics combined with miR-340 inhibitors reactivated the Nrf2 related pathway and restored the resistance of HepG2/CDDP cells to CDDP. Collectively, the results first suggested that lower expression of miR-340 is involved in the development of CDDP resistance in hepatocellular carcinoma cell line, at least partly due to regulating Nrf2-dependent antioxidant pathway.
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Cyclic Behavior of Steel Frame Joints in the Offshore Atmospheric Environment
Qiang Xu,Xiaoyu Shang,Shansuo Zheng 한국강구조학회 2020 International Journal of Steel Structures Vol.20 No.3
The natural deterioration of mild steel elements exposed to off shore atmospheric environments compromises the long-term safety of existing steel buildings. An experimental study was conducted to investigate the eff ect of the off shore atmospheric environment on the seismic performance of steel frame joints. An indoor accelerated corrosion test was conducted to simulate the degradation of the mechanical properties of the materials and steel frame joints in the off shore atmospheric environment. After determining the corrosion rate by weighing after rust removal, the yield strength, ultimate strength, modulus of elasticity, and elongation of three test specimen with diff erent thicknesses were obtained by regression of the tensile failure test, which demonstrated a linear decay relationship with the corrosion rate. Under four diff erent corrosion degrees and three diff erent low-cycle reciprocating loads, the failure modes of 12 steel frame joints were all plate-tearing at welded through holes. However, the diff erence is that the joints had ductile failure under equal-amplitude 90 mm loading and brittle failure under variable-amplitude loading. The eff ects of corrosion on the hysteresis behavior, deformation degradation, strength degradation, and energy dissipation capacity of steel frame joints were analyzed. The test results indicate that corrosion has signifi cant eff ects on the seismic performance of steel frame joints. With the increase in corrosion degree, the energy dissipation capacity of steel frame joints declines more signifi cantly than other performance indicators, and the yield platform of the steel frame joints is not evident.
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Impact of WS2 Nanoparticles on Nitrile Butadiene Rubber Properties
Qiang He,Guangfei Wang,Bo Zheng,Wei Zhou,Yanbin Zhang 한국섬유공학회 2020 Fibers and polymers Vol.21 No.5
WS2/nitrile butadiene rubber (NBR) nanocomposite was prepared by mechanical blending. The vulcanization andmechanical behavior, contact angle with water, friction and wear properties, as well as thermal stability were measured toinvestigate the influence of nano WS2 content on the NBR. Moreover, scanning electron microscopic (SEM) and elementdispersive spectrum analysis (EDS) were used to analyze the tensile failure mechanism of the WS2/NBR nanocomposite. Results showed that the tensile strength, elongation at break and contact angle with water of the vulcanized rubber reachedtheir maxima when the content of nano WS2 was 10 parts. Furthermore, fast vulcanization rate and the minimum friction andwear properties were also observed. The tear strength, rebound resilience and electrical resistivity decreased with theincrement of WS2 content, while the hardness and thermal stability increased. Investigation on tensile fracture showed thatcrack growth was mainly caused by stress concentration.
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