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MicroRNA-16 Inhibits Bladder Cancer Proliferation by Targeting Cyclin D1
Jiang, Qi-Quan,Liu, Bin,Yuan, Tao Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.7
MicroRNA-16 (miR-16) has been demonstrated to regulate proliferation and apoptosis in many types of cancers, but its biological function in bladder cancer remains unknown. Here, we found expression of miR-16 to be downregulated in bladder cancer in comparison with the adjacent normal tissues. Enforced expression of miR-16 was able to inhibit cell proliferation in TCHu-1 cells, in line with results for miR-16 antisense oligonucleotides (antisense miR-16). At the molecular level, our results further revealed that cyclin D1 expression was negatively regulated by miR-16. Therefore, the data reported here demonstrate that miR-16 is an important regulator in bladder cancer, which will contribute to better understanding of important mis-regulated miRNAs.
Qi Jiang,Yumei Ma,Jiapeng Liu,Jinpeng Yu 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.8
In this paper, the problem of full state constraints-based adaptive fuzzy finite-time command filtered control (FTCFC) is investigated for permanent magnet synchronous motor (PMSM) stochastic systems. Firstly, the barrier Lyapunov functions are introduced to avoid the violation of the state constraints. Then, the unknown nonlinear functions are approximated by the fuzzy logic systems (FLSs) in PMSM stochastic systems. Furthermore, the finite-time control method is proposed by combing command filtered backstepping and adaptive fuzzy control, and the improved finite-time command filter can solve the problem of “explosion of complexity”, and relax the condition of input signal. It is shown that the required tracking performance can be realized in finite time, and the boundedness of all signals in the closed-loop system is guaranteed. Finally, simulation results illustrate the validity of the studied method.
Dynamic File Grouping for Load Balancing in Streaming Media Clustered Server Systems
Qi Jiang,Hong-Sheng Xi,Bao-Chen Yin 제어·로봇·시스템학회 2009 International Journal of Control, Automation, and Vol.7 No.4
A dynamic file grouping strategy is presented to address the load balancing problem in streaming media clustered server systems. This strategy increases the server cluster availability by balancing the workloads among the servers within a cluster. Additionally, it improves the access hit ratio of cached files in delivery servers to alleviate the limitation of I/O bandwidth of storage node. First, the load balancing problem is formulated as a two layers semi-Markov switching state-space control process. This analytic model captures the behaviors of streaming media clustered server systems accurately, and is with constructional flexibility and scalability. Then, a policy iteration based reinforcement learning algorithm is proposed to optimize the file grouping policy online. By utilizing the features of the event-driven policy, the proposed optimization algorithm is adaptive and with less computational cost. Simulation results demonstrate the effectiveness of the proposed approach.
Qi Jiang,Zaixiang Lou,Hongxin Wang,Chen Chen 한국미생물학회 2019 The journal of microbiology Vol.57 No.4
The detailed antibacterial mechanism of cordycepin efficacy against food-borne germs remains ambiguous. In this study, the antibacterial activity and action mechanism of cordycepin were assessed. The results showed that cordycepin effectively inhibited the growth of seven bacterial pathogens including both Gram-positive and Gram-negative bacterial pathogens; the minimum inhibitory concentrations (MIC) were 2.5 and 1.25 mg/ml against Escherichia coli and Bacillus subtilis, respectively. Scanning electron microscope and transmission electron microscope examination confirmed that cordycepin caused obvious damages in the cytoplasmatic membranes of both E. coli and B. subtilis. Outer membrane permeability assessment indicated the loss of barrier function and the leakage of cytoplasmic contents. Propidium iodide and carboxyfluorescein diacetate double staining approach coupled with flow cytometry analysis indicated that the integrity of cell membrane was severely damaged during a short time, while the intracellular enzyme system still remained active. This clearly suggested that membrane damage was one of the reasons for cordycepin efficacy against bacteria. Additionally, results from circular dichroism and fluorescence analysis indicated cordycepin could insert to genome DNA base and double strand, which disordered the structure of genomic DNA. Basis on these results, the mode of bactericidal action of cordycepin against E. coli and B. subtilis was found to be a dual mechanism, disrupting bacterial cell membranes and binding to bacterial genomic DNA to interfere in cellular functions, ultimately leading to cell death.
Qi Jiang,Miyea Kim,Eunju Ko,Kyohong Jin,Kanghyeon Shin,Ju-Hyo Hwang,Kyung Hoon Kim 글로벌지식마케팅경영학회 2023 Global Marketing Conference Vol.2023 No.07
Metaverse provides technology for people to connect, find communities, and grow businesses. Its sales have seen growth during the COVID-19 pandemic. In an era of metaverse, luxury brands such as Gucci, Ralph Lauren, Burberry, Balenciaga, and Dolce & Gabbana are trying to adapt to new changes. They launched NFT(Non-fungible token) goods, digital fashion, and virtual luxury goods on various metaverse platforms such as Zepeto, Roblox, and Fortnite. For example, Ralph Lauren in Zepeto provides various types of luxury items, immerses in virtual performances, and has a game plot interaction. As people immerse themselves in the Metaverse, they feel happy from various activities—such as watching advertisements, drinking juice, and playing with friends. Thus, what factors should be considered when the luxury brands manage the metaverse?