關於"動詞+趨向補語"方向價的 類型及位移句句型的建立

제호양 中國語文硏究會 1996 中國語文論叢 Vol.11 No.-

Hypoxia-Inducible Factor 1 Promoter-Induced JAB1 Overexpression Enhances Chemotherapeutic Sensitivity of Lung Cancer Cell Line A549 in an Anoxic Environment

Hu, Ming-Dong,Xu, Jian-Cheng,Fan, Ye,Xie, Qi-Chao,Li, Qi,Zhou, Chang-Xi,Mao, Mei,Yang, Yu Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

The presence of lung cancer cells in anoxic zones is a key cause od chemotherapeutic resistance. Thus, it is necessary to enhance the sensitivity of such lung cancer cells. However, loss of efficient gene therapeutic targeting and inefficient objective gene expression in the anoxic zone in lung cancer are dilemmas. In the present study, a eukaryotic expression plasmid pUC57-HRE-JAB1 driven by a hypoxia response elements promoter was constructed and introduced into lung cancer cell line A549. The cells were then exposed to a chemotherapeutic drug cis-diamminedichloroplatinum (C-DDP). qRT-PCR and western blotting were used to determine the mRNA and protein level and flow cytometry to examine the cell cycle and apoptosis of A549 transfected pUC57-HRE-JAB1. The results showed that JAB1 gene in the A549 was overexpressed after the transfection, cell proliferation being arrested in G1 phase and the apoptosis ratio significantly increased. Importantly, introduction of pUC57-HRE-JAB1 significantly increased the chemotherapeutic sensitivity of A549 in an anoxic environment. In conclusion, JAB1 overexpression might provide a novel strategy to overcome chemotherapeutic resistance in lung cancer.

Methods on improvements of the poor oral bioavailability of ginsenosides: Pre-processing, structural modifi cation, drug combination, and micro- or nano- delivery system

Qi-rui Hu,Huan Hong,Zhi-hong Zhang,Hua Feng,Ting Luo,Jing Li,Ze-yuan Deng,Fang Chen 고려인삼학회 2023 Journal of Ginseng Research Vol.47 No.6

Panax ginseng Meyer is a traditional Chinese medicine that is widely used as tonic in Asia. The mainpharmacologically active components of ginseng are the dammarane-type ginsenosides, which havebeen shown to have anti-cancer, anti-inflammatory, immunoregulatory, neuroprotective, and metabolicregulatory activities. Moreover, some of ginsenosides (eg, Rh2 and Rg3) have been developed intonutraceuticals. However, the utilization of ginsenosides in clinic is restrictive due to poor permeability incells and low bioavailability in human body. Obviously, the dammarane skeleton and glycosyls of ginsenosidesare responsible for these limitations. Therefore, improving the oral bioavailability of ginsenosideshas become a pressing issue. Here, based on the structures of ginsenosides, we summarized theunderstanding of the factors affecting the oral bioavailability of ginsenosides, introduced the methods toenhance the oral bioavailability and proposed the future perspectives on improving the oral bioavailabilityof ginsenosides.

Beneficial effects of andrographolide in a rat model of autoimmune myocarditis and its effects on PI3K/Akt pathway

Qi Zhang,Li-qun Hu,Hong-qi Li,Jun Wu,Na-na-Bian,Guang Yan 대한약리학회 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.2

The study is to investigate effects of andrographolide on experimental autoimmune myocarditis (EAM). Lewis rats were immunized on day 0 with porcine cardiac myosin to establish EAM. The EAM rats were treated with either andrographolide (25, 50, 100 mg/kg/day) or vehicle for 21 days. An antigen-specific splenocytes proliferation assay was performed by using the cells from control rats immunized with cardiac myosin. Survival rates, myocardial pathology and myocardial functional parameters (left ventricle end-diastolic pressure, ± dP/dt and left ventricular internal dimension) of EAM rats received andrographolide were significantly improved. Andrographolide treatment caused an decrease in the infiltration of CD3+ and CD14+ positive cells in myocardial tissue. Moreover, andrographolide treatment caused a reduction in the plasma levels of tumor necrosis factor-alpha, interleukin-17 (IL-17) and myosin-antibody, and an increase in the level of IL-10 in EAM rats. Oral administration of andrographolide resulted in the decreased expression of p-PI3K, p-Akt without any change of PI3K and Akt. Further results indicate andrographolide significantly inhibited myosin-induced proliferation in splenocytes, and this effect was inhibited by co-treatment of SC79 (Akt activator). Our data indicate andrographolide inhibits development of EAM, and this beneficial effect may be due to powerful anti-inflammatory activity and inhibitory effect on PI3K/Akt pathway.

Tradeoff Control of Multi-exposure Lithography for SU-8 Photochemical Reaction Channel Formation

Qi-Ming Chen,Jin-Yun Zhou,Yi-Ming Hu,Qi Zheng 한국바이오칩학회 2020 BioChip Journal Vol.14 No.4

A method involving multi-exposure with low-power is presented to fabricate an SU-8 mold based on a digital micromirror device (DMD) maskless lithography with an LED source at a wavelength of 405 nm. The SU-8 mold is used for the fabrication of a PDMS concentration gradient generator (CGG). During a one-time exposure, it is easy to over-expose at the top and under-expose at the bottom of a thick SU-8, which then forms a T-shaped structure. This is more obvious for high-absorption coefficients such as 365 nm. We found that by taking advantage of the partially absorbed and partially transmissive characteristics of the 405-nm wavelength, multi-exposure can form an effective photochemical reaction channel in SU-8 and can solve the problem mentioned above. However, excessive exposure will cause the linewidth to increase, therefore, it is necessary to find a tradeoff for the number of multi-exposure times. For a 55-μm thick SU-8, the tradeoff threshold is found to be 25. Three types of SU-8 CGG molds were fabricated at this threshold. The results indicate that the actual profile of the SU-8 mold shows good agreement with the design profile without any T-shaped structures.

Influencing Factors of High PTSD Among Medical Staff During COVID-19: Evidences From Both Meta-analysis and Subgroup Analysis

Qi, Guojia,Yuan, Ping,Qi, Miao,Hu, Xiuli,Shi, Shangpeng,Shi, Xiuquan Occupational Safety and Health Research Institute 2022 Safety and health at work Vol.13 No.3

Background: PTSD (Post-traumatic stress disorder, PTSD) had a great impact on health care workers during the COVID-19 (Corona Virus Disease 2019, COVID-19). Better knowledge of the prevalence of PTSD and its risk factors is a major public health problem. This study was conducted to assess the prevalence and important risk factors of PTSD among medical staff during the COVID-19. Methods: The databases were searched for studies published during the COVID-19, and a PRISMA (preferred reporting items for systematic review and meta-analysis) compliant systematic review (PROSPERO-CRD 42021278970) was carried out to identify articles from multiple databases reporting the prevalence of PTSD outcomes among medical staff. Proportion random effect analysis, I² statistic, quality assessment, subgroup analysis, and sensitivity analysis were carried out. Results: A total of 28 cross-sectional studies and the PTSD results of doctors and nurses were summarized from 14 and 27 studies: the prevalences were 31% (95% CI [confidence interval, CI]: 21%-40%) and 38% (95% CI: 30%-45%) in doctors and nurses, respectively. The results also showed seven risks (p < 0.05): long working hours, isolation wards, COVID-19 symptoms, nurses, women, fear of infection, and pre-existing mental illness. Two factors were of borderline significance: higher professional titles and married. Conclusion: Health care workers have a higher prevalence of PTSD during COVID-19. Health departments should provide targeted preventive measures for medical staff away from PTSD.

The ways for ginsenoside Rh2 to fight against cancer: the molecular evidences in vitro and in vivo.

Qi-rui Hu,Yao Pan,Han-cheng Wu,Zhen-zhen Dai,Qing-xin Huang,Ting Luo,Jing Li,Ze-yuan Deng,Fang Chen The Korean Society of Ginseng 2023 Journal of Ginseng Research Vol.47 No.2

Cancer is a global public health issue that becomes the second primary cause of death globally. Considering the side effects of radio- or chemo-therapy, natural phytochemicals are promising alternatives for therapeutic interventions to alleviate the side effects and complications. Ginsenoside Rh2 (GRh2) is the main phytochemical extracted from Panax ginseng C.A. Meyer with anticancer activity. GRh2 could induce apoptosis and autophagy of cancer cells and inhibit proliferation, metastasis, invasion, and angiogenesis in vitro and in vivo. In addition, GRh2 could be used as an adjuvant to chemotherapeutics to enhance the anticancer effect and reverse the adverse effects. Here we summarized the understanding of the molecular mechanisms underlying the anticancer effects of GRh2 and proposed future directions to promote the development and application of GRh2.

Electronic and optical properties of graphane, silicane, MoS2 homo-bilayers and hetero-bilayers

Jia-Qi Hu,Lin-Han Xu,Shun-Qing Wu,Zi-Zhong Zhu 한국물리학회 2019 Current Applied Physics Vol.19 No.11

The electronic and optical properties of graphane, silicane and MoS2 bilayers, as well as the graphane/MoS2 and silicane/MoS2 hetero-bilayers, are calculated by the first-principles method. The interlayer interactions of all the bilayer systems are shown to be mainly van der Waals. Both the graphane/MoS2 and silicane/MoS2 heterobilayers belong to the type-II heterostructure, which can be utilized in photo-voltaic devices due to the efficient spatial separation of electrons and holes. For optical properties, the distinctions for the imaginary parts of the dielectric function 2 ( ) between the monolayer and bilayer systems for both the graphane and silicane are more evident in electric vector E||z. However, the differences between 2 ( ) of the monolayer and bilayer MoS2 materials are more significant in E||x. Broader light absorption ranges of the hetero-bilayers are reached, which can also improve the charge separation of the electron-hole pairs.

Beneficial effects of andrographolide in a rat model of autoimmune myocarditis and its effects on PI3K/Akt pathway

Zhang, Qi,Hu, Li-qun,Li, Hong-qi,Wu, Jun,Bian, Na-na,Yan, Guang The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.2

The study is to investigate effects of andrographolide on experimental autoimmune myocarditis (EAM). Lewis rats were immunized on day 0 with porcine cardiac myosin to establish EAM. The EAM rats were treated with either andrographolide (25, 50, 100 mg/kg/day) or vehicle for 21 days. An antigen-specific splenocytes proliferation assay was performed by using the cells from control rats immunized with cardiac myosin. Survival rates, myocardial pathology and myocardial functional parameters (left ventricle end-diastolic pressure, ${\pm}dP/dt$ and left ventricular internal dimension) of EAM rats received andrographolide were significantly improved. Andrographolide treatment caused an decrease in the infiltration of $CD3^+$ and $CD14^+$ positive cells in myocardial tissue. Moreover, andrographolide treatment caused a reduction in the plasma levels of tumor necrosis factor-alpha, interleukin-17 (IL-17) and myosin-antibody, and an increase in the level of IL-10 in EAM rats. Oral administration of andrographolide resulted in the decreased expression of p-PI3K, p-Akt without any change of PI3K and Akt. Further results indicate andrographolide significantly inhibited myosin-induced proliferation in splenocytes, and this effect was inhibited by co-treatment of SC79 (Akt activator). Our data indicate andrographolide inhibits development of EAM, and this beneficial effect may be due to powerful anti-inflammatory activity and inhibitory effect on PI3K/Akt pathway.

Optimized Distributed Fusion Filtering for Uncertain Nonlinear Systems With Missing Measurements: Algorithm Design and Boundedness Analysis

Zhibin Hu,Jun Hu,Junhua Du,Hongjian Liu,Jun Qi 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.10

This paper investigates the optimized distributed fusion filtering (DFF) problem for a class of nonlinear discrete time-varying stochastic systems with randomly occurring uncertainty (ROU) and missing measurements (MMs). The stochastic nonlinearity is depicted in terms of statistical means. The phenomena of the ROU and MMs are considered during the modelling of state equation and measurement output respectively, which are characterized by Bernoulli distributed random variables. In order to deal with the effect of the parameter uncertainty, the method that the local estimation error covariances and cross-covariances from all estimators at every sample time are replaced by their upper bounds is adopted. Moreover, the minimum upper bounds for each filtering error covariance (FEC) are obtained by designing the corresponding filter gains. Based on the local filters, a new robust DFF algorithm is developed via the matrix-weighted fusion method. In addition, a sufficient condition concerning on the performance analysis of the developed algorithm is given, which can show that the boundedness of the upper bound for each FEC is guaranteed. Finally, a numerical example is provided to manifest the usefulness of the developed distributed fusion algorithm.