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TRANS FORM / CONTENT & COLLABORATION
Marvin Pyles 한국데이터베이스진흥원 2003 디지털콘텐츠 Vol.12 No.-
Sarbanes-Oxley Act, HIPAA, 새로운 SEC 규칙 및 기타 제정되는 각종 법률 및 명령이 콘텐츠 및 레코드 관리 기술들을 대부분 기업에서의 가장 중요한 감시 목록으로 만들고 있다.
Ringing the Bell: Does it Matter and Why?
Steve D. Dolvin,Hinh D. Khieu,Mark K. Pyles 사람과세계경영학회 2009 Global Business and Finance Review Vol.14 No.2
We explore the ongoing debate between market efficiency and behavioral finance by examining the market’ s reaction to what most investors would consider an information-neutral event: a firm ringing the opening or closing bell on the NYSE. Consistent with behavioral theories, we find that firms who ring the opening bell experience, on average, a positive abnormal return on the event day; however, we find that the reaction is concentrated in a particular group of participants. Specifically, we find the abnormal returns are driven almost entirely by firms who are celebrating the transfer of their stock listing to the NYSE. Given the potential benefits and signals associated with such an event, the favorable reaction is more consistent with market efficiency than any type of behavioral bias (i.e., the event is not information- neutral). In a more general sense, we caution against blanket conclusions of inefficiency that may result from a failure to more closely examine underlying causes for certain market reactions.
Pyle, Bryan W.,Tran, Hue T.,Pickel, Benjamin,Haslam, Tegan M.,Gao, Zhizeng,MacNevin, Gillian,Vederas, John C.,Kim, Soo‐,Un,Ro, Dae‐,Kyun Blackwell Publishing Ltd 2012 The FEBS journal Vol.279 No.17
<P>Valerian (<I>Valeriana</I> <I>officinalis</I>) is a popular medicinal plant in North America and Europe. Its root extract is commonly used as a mild sedative and anxiolytic. Among dozens of chemical constituents (e.g. alkaloids, iridoids, flavonoids, and terpenoids) found in valerian root, valerena‐4,7(11)‐diene and valerenic acid (C15 sesquiterpenoid) have been suggested as the active ingredients responsible for the sedative effect. However, the biosynthesis of the valerena‐4,7(11)‐diene hydrocarbon skeleton in valerian remains unknown to date. To identify the responsible terpene synthase, next‐generation sequencing (Roche 454 pyrosequencing) was used to generate ∼ 1 million transcript reads from valerian root. From the assembled transcripts, two sesquiterpene synthases were identified (<I>VoTPS1</I> and <I>VoTPS2</I>), both of which showed predominant expression patterns in root. Transgenic yeast expressing <I>VoTPS1</I> and <I>VoTPS2</I> produced germacrene C/germacrene D and valerena‐4,7(11)‐diene, respectively, as major terpene products. Purified VoTPS1 and VoTPS2 recombinant enzymes confirmed these activities <I>in vitro</I>, with competent kinetic properties (<I>K</I><SUB>m</SUB> of ∼ 10 μ<SMALL>m</SMALL> and <I>k</I><SUB>cat</SUB> of 0.01 s<SUP>−1</SUP> for both enzymes). The structure of the valerena‐4,7(11)‐diene produced from the yeast expressing <I>VoTPS2</I> was further substantiated by <SUP>13</SUP>C‐NMR and GC‐MS in comparison with the synthetic standard. This study demonstrates an integrative approach involving next‐generation sequencing and metabolically engineered microbes to expand our knowledge of terpenoid diversity in medicinal plants.</P><P><B>Database</B> The sequences of cDNAs described in this work are available in the GenBank database under the following accession numbers: VoTPS1, JQ437839; VoTPS2, JQ437840</P>
( Taylor Braden ),( Madison Burtch ),( Samantha Mott ),( Alexandria Pyle ),( Lee Atkins ),( Heather Braden ) 대한신경치료학회 2021 신경치료 Vol.25 No.1
Purpose Assessing functional mobility is an important aspect of determining fall risk in the growing population of assisted living. Little is known about the sit-to-walk (STW) transition, especially what characteristics correlate with the duration it takes to perform a STW. Methods In this cross-sectional, exploratory study, 45 assisted living residents were evaluated for baseline measures: history of falls, assistive device (AD), lower-extremity strength, and balance (Tinetti POMA). The residents were then timed performing a STW, and, from these durations, were stratified into fast and slow groups. Statistical analysis was performed to determine relationships between the two duration groups and the baseline measures. Results Participants who had experienced a fall were significantly more likely to use an assistive device (p = 0.001). The use of an AD had a moderate negative correlation with composite strength (r = -0.428, p = 0.003). Duration of STW had a weak negative correlation with composite strength (r = -0.299, p = 0.046) and a moderate correlation with use of AD (r = 0.419, p = 0.004). Those with a faster duration of STW had significantly better balance (p = 0.027). Conclusion These correlations support the need for healthcare professionals to address the use of adaptive equipment and physical training when evaluating functional mobility in assisted living residents. Providing appropriate equipment and improving overall strength in these individuals can help reduce their risk of falls. Individuals in assisted living facilities can be assessed similar to other geriatric populations, with special consideration on functional tasks and measures.
Installation of Neutron Monitor at the Jang Bogo Station in Antarctica
정종일,오수연,이유,Paul Evenson,Roger Pyle,지건화,김정한,이창섭,손종대 한국우주과학회 2016 Journal of Astronomy and Space Sciences Vol.33 No.4
In December 2015, we have installed neutron monitor at the Jang Bogo station in Antarctica. The Jang Bogo station is the second science station which is located at the coast (74° 37.4´S, 164° 13.7´E) of Terra Nova Bay in Northern Victoria Land of Antarctica. A neutron monitor is an instrument to detect neutrons from secondary cosmic rays collided by the atmosphere. The installation of neutron monitor at Jang Bogo station is a part of transferred mission for neutron monitor at McMurdo station of USA. Among 18 tubes of 18-NM64 neutron monitor, we have completed relocation of 6 tubes and the rest will be transferred in December 2017. Currently, comparison of data from both neutron monitors is under way and there is a good agreement between the data. The neutron monitor at Jang Bogo station will be quite useful to study the space weather when the installation is completed.
Harata, Nobutoshi C.,Choi, Sukwoo,Pyle, Jason L.,Aravanis, Alexander M.,Tsien, Richard W. Elsevier 2006 Neuron Vol.49 No.2
<P><B>Summary</B></P><P>The kinetics of exo-endocytotic recycling could restrict information transfer at central synapses if neurotransmission were entirely reliant on classical full-collapse fusion. Nonclassical fusion retrieval by kiss-and-run would be kinetically advantageous but remains controversial. We used a hydrophilic quencher, bromophenol blue (BPB), to help detect nonclassical events. Upon stimulation, extracellular BPB entered synaptic vesicles and quenched FM1-43 fluorescence, indicating retention of FM dye beyond first fusion. BPB also quenched fluorescence of VAMP (synaptobrevin-2)-EGFP, thus indicating the timing of first fusion of vesicles in the total recycling pool. Comparison with FM dye destaining revealed that kiss-and-run strongly prevailed over full-collapse fusion at low frequency, giving way to a near-even balance at high frequency. Quickening of kiss-and-run vesicle reuse was also observed at higher frequency in the average single vesicle fluorescence response. Kiss-and-run and reuse could enable hippocampal nerve terminals to conserve scarce vesicular resources when responding to widely varying input patterns.</P>
Peng, Jinliang,Garcia, Mitch André,Choi, Jin-sil,Zhao, Libo,Chen, Kuan-Ju,Bernstein, James R.,Peyda, Parham,Hsiao, Yu-Sheng,Liu, Katherine W.,Lin, Wei-Yu,Pyle, April D.,Wang, Hao,Hou, Shuang,Tse American Chemical Society 2014 ACS NANO Vol.8 No.5
<P/><P>Substrate-mediated gene delivery is a promising method due to its unique ability to preconcentrate exogenous genes onto designated substrates. However, many challenges remain to enable continuous and multiround delivery of the gene using the same substrates without depositing payloads and immobilizing cells in each round of delivery. Herein we introduce a gene delivery system, nanosubstrate-mediated delivery (NSMD) platform, based on two functional components with nanoscale features, including (1) DNA⊂SNPs, supramolecular nanoparticle (SNP) vectors for gene encapsulation, and (2) Ad-SiNWS, adamantane (Ad)-grafted silicon nanowire substrates. The multivalent molecular recognition between the Ad motifs on Ad-SiNWS and the β-cyclodextrin (CD) motifs on DNA⊂SNPs leads to dynamic assembly and local enrichment of DNA⊂SNPs from the surrounding medium onto Ad-SiNWS. Subsequently, once cells settled on the substrate, DNA⊂SNPs enriched on Ad-SiNWS were introduced through the cell membranes by intimate contact with individual nanowires on Ad-SiNWS, resulting in a highly efficient delivery of exogenous genes. Most importantly, sequential delivery of multiple batches of exogenous genes on the same batch cells settled on Ad-SiNWS was realized by sequential additions of the corresponding DNA⊂SNPs with equivalent efficiency. Moreover, using the NSMD platform <I>in vivo</I>, cells recruited on subcutaneously transplanted Ad-SiNWS were also efficiently transfected with exogenous genes loaded into SNPs, validating the <I>in vivo</I> feasibility of this system. We believe that this nanosubstrate-mediated delivery platform will provide a superior system for <I>in vitro</I> and <I>in vivo</I> gene delivery and can be further used for the encapsulation and delivery of other biomolecules.</P>