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Prafulla Kumar Sahoo,Wei Zhu,김석휘,정명채,김강주 한국지질과학협의회 2013 Geosciences Journal Vol.17 No.3
Serious groundwater arsenic (As) contaminations are frequently associated with alluvial plains, and which are mostly used for rice cultivation in Asian countries. Because rice cultivation requires large quantities of irrigation, the long-term use of As-contaminated groundwater for irrigation may cause As contamination in the soil with a consequent impact on rice grains. In this study, we investigated As concentrations in groundwater, soil and rice and the soil properties from an alluvial plain of the Mankyeong River, Korea, to understand their relations from the viewpoint of As contamination in rice. Arsenic in the rice varied from 0.03 mg/kg to 0.22 mg/kg, with a mean of 0.13 mg/kg, which is much lower than the World Health Organization’s maximum permissible limit of As in rice (1.0 mg/kg). Some groundwater samples showed As concentrations much higher than the drinking water standard (10 ug/L). Despite the rice As is independent of groundwater As it showed a good relation with soil As and Fe-oxide fractions. Because As is mainly occurred in Fe-oxide fractions and the soil is mostly silty, it is speculated that under flooding conditions arsenic can easily mobilize to the soil solution and potentially be available for plants. However, this availability can be controlled by As uptake mechanisms and/or incomplete reduction of Fe-oxides. It is observed that rice As is significantly correlated with soil exchangeable-PO4 (r = –0.41, p < 0.05), indicating that PO4 competition in the soil-rhizosphere may be one of the factors controlling rice As.
A review of the arsenic concentration in paddy rice from the perspective of geoscience
Prafulla Kumar Sahoo,김강주 한국지질과학협의회 2013 Geosciences Journal Vol.17 No.1
Along with contaminated drinking water, arsenic (As) contamination in rice has become a global concern as a potential dietary risk to human health. Arsenic naturally occurs in paddy soil and can be increased by irrigating with As-rich groundwater, which may have subsequent impact on rice grains. There have been many studies on As concentration in rice. Some studies have revealed that As concentration in rice depends on the As content in irrigated groundwater and soil, whereas others have shown that various other factors control As solubility, bioavailability and uptake in the soil-rhizosphere-plant system. This review discusses the major factors controlling As behavior in the soil-rhizosphere-plant system and the current status of As contamination in paddy rice from different parts of the world. Understanding this aspect is crucial for minimizing As toxicity in rice plants.
Prafulla Choudhari,Manish Bhatia,Neela Bhatia 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.9
The present communication deals with development of ten novel N-Phenyl-3-Pyridin-2-yl imino derivatives as vascular smooth muscle relaxants. The derivatives were prepared and optimized using pocket modelling and pharmacophore modelling. The 4 hydroxy substituted derivatives are showed potent activity comparable to the sildenafil.
Prafulla M. Mahajan,Smita S. Lele,Sagar V. Gokhale 한국식품과학회 2010 Food Science and Biotechnology Vol.19 No.6
Fermentative production of nattokinase, a potent fibrinolytic enzyme using Bacillus natto NRRL 3666 was optimized by statistical optimization methods at shake flask. In addition, the production scheme based on optimum medium was scaled-up in 5-L lab-scale fermenter containing 2.5 L working volume. Further, unstructured mathematical models were proposed for kinetics of batch fermentation at shake flask as well as fermenter level for nattokinase. Enhanced production of nattokinase from 188±2.4 to 1,190.68±11 U/mL within 40 hr was achieved at shake flask. Nattokinase production improved to 1,932 U/mL in fermenter, which was 1.6 fold higher than shake flask. The production process was significantly reduced to 26 hr in the fermenter. The proposed models showed better prediction for experimental data with respect to biomass formation (R2>0.96), enzyme production (R2>0.99), and substrate utilization (R2>0.96). The present work showed successful optimization of medium for hyperproduction of nattokinase.
Naik, Prafulla-Ramchandra,Singh, Girija-Shankar,Pandeya, Surendra-Nath,Singh, Paras-Nath The Pharmaceutical Society of Korea 1994 Archives of Pharmacal Research Vol.17 No.4
The titled compounds have been synthesized by the oxidative cyclization of N-ethyl-N'-aryl-thioureas and screened for their anti-inflammatory and analogesic activities. Some of the compounds exhibit significant activities.
Choudhari, Prafulla B.,Bhatia, Manish S.,Jadhav, Swapnil D. Korean Chemical Society 2013 대한화학회지 Vol.57 No.1
The present communication deals with the Pharmacophore modeling, 3D QSAR and docking analysis on series of Pyrimidine derivatives as potential calcium channel blockers. The computational studies showed hydrogen bond donor, hydrogen bond acceptor, and hydrophobic group are important features for calcium channel blocking activity. These studies showed that Pyrimidine scaffold can be utilized for designing of novel calcium channels blockers for CVS disorders.
Two Sequential Wilcoxon Tests for Scale Alternatives
Mishra, Prafulla-Chandra The Korean Statistical Society 2001 Journal of the Korean Statistical Society Vol.30 No.4
Two truncated sequential tests are developed for the two-sample scale problem based on the usual Wilcoxon rank-sum statistic for two different dispersion indices - absolute median deviations, when the medians of the two populations X and Y are equal or known and sums of squared mean deviations, when the medians are either unknown or unequal. The first test is briefly called SWAMD test and the second SWSMD test. For the SWAMD test, the percentile points for both the one-sided and two-sided alternatives, (equation omitted) have been found by Wiener approximation and their values computed for a range of values of a and N; analytical expression for the power function has been derived through Wiener process and its performance studied for various sequential designs for exponential distribution. This test has been illustrated by a numerical example. All the results of the SWAMD test, being directly applicable to the SWSMD test, are not dealt with separately Both the tests are compared and their suitable applications indicated.
Choudhari, Prafulla,Bhatia, Manish,Bhatia, Neela Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.9
The present communication deals with development of ten novel N-Phenyl-3-Pyridin-2-yl imino derivatives as vascular smooth muscle relaxants. The derivatives were prepared and optimized using pocket modelling and pharmacophore modelling. The 4 hydroxy substituted derivatives are showed potent activity comparable to the sildenafil.
Pharmacognostic and pharmacological perspectives of Leea macrophyla roxb.
Padmaja Kota,Prafulla Kumar Sahu,Mary Sulakshana Palla,Jagadeesh Panda,Prasanth Damarasingu,Santosh Kumar Ranajit 경희대학교 융합한의과학연구소 2023 Oriental Pharmacy and Experimental Medicine Vol.23 No.4
The proposed work on Leea macrophyla Roxb (family: Leeaceae) is mainly focused on two different streams, first towards the pharmacognostic profile and second on pharmacological evaluation. The pharmacognostic profile involves the study of both macroscopy and microscopy of leaf, stem, and tuberous roots. Secondly, extract of adventitious tuberous roots of the plant was used for pharmacological screening of anti-inflammatory (in-vivo), antimicrobial (in-vitro), and antioxidant (in-vitro) potential. Morphologically, it is observed that L. macrophyla is an herb with erect stem, broadly ovate leaf with greenish-white inflorescence. Microscopically, the leaf can be characterized by anisocytic stomata, calcium oxalate crystals, and the absence of trichomes. The typical characteristics of the stem include outer thick ridges, secondary phloem, medullary rays, and pith. The rhizomes contain the outer epidermis is replaced with dark crushed cells, central pith, and disintegrated parenchymatous cells.The extract exhibited excellent anti-inflammatory potency in carrageenan-induced rat paw edema. Antimicrobial activity was involved cup plate technique against gram-positive, gram-negative, and fungal organisms. The study observed good inhibitory activity against S. aureus (15 ± 0.15 mm), B. subtilis (14 ± 0.13 mm), and E. coli (15 ± 0.16 mm). 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and hydroxyl radical scavenging method was used to explore antioxidant potential against ascorbic acid as standard. The IC50 values obtained from the antioxidant potency were observed to be 18 ± 0.33, 12 ± 0.66% for DPPH and hydroxyl radical scavenging assay respectively. As L. macrophyla with assumption on the traditional curative assurance, it shows significant anti-inflammatory, antibacterial and antioxidant potency.
Shinde Sachin D.,Cheke Rameshwar S.,Tathe Prafulla R.,Jain Pankaj G.,Narkhede Rohan R. 경희대학교 융합한의과학연구소 2021 Oriental Pharmacy and Experimental Medicine Vol.21 No.4
The objective of the present study was to evaluate the effect of Berberis aristata (BA) against oxazolone induced contact dermatitis in Balb/c mice and molecular docking with TLR-1 and TLR-2. Dermatitis was induced in Balb/c mice by sensitizing with topical application of 100 μl oxazolone (2%) and the effect of BA was screened in two doses (200 mg/kg and 400 mg/ kg P.O.). The effect was evaluated by the change in ear thickness, anti-inflammatory cytokine (TNF-α, IL-6, and IL-1β) and oxidative stress on the sixth day in ear tissue homogenate. The ear skin of all group mice was subjected to histological analysis. This work was further evidenced by the docking of berberine with crystal structure of TLR1-TLR2 heterodimer caused by using the binding of tri-acylated lipopeptide (PDB ID: 2Z7X). In this study, we found that a significant reduction in ear thickness was found in BA (200 mg/kg and 400 mg/kg) as compared to 100 μl oxazolone(2%) treated mice. The reduction level of GSH and SOD found in 100 μl oxazolone (2%) sensitized mice. BA (200 mg/kg and 400 mg/kg) treated animals showed an increase in GSH and SOD levels. A significant reduction in inflammatory cytokines was observed in BA treated mice and indicates anti-inflammatory activity against oxazolone. Histopathological analysis showed minimal infiltration of lymphocytes and moderate harm to skin cells and layer in BA treated mice. Docking studies revealed promising binding interaction of berberine withTLR1-TLR2 heterodimer which can attribute to its anti dermatic effect. This present research shows that BA has a dose-dependent effect in contact dermatitis attenuated by oxazolone.