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      • KCI등재SCOPUS

        Rapid Identification and Characterization of Antioxidants from Ligularia fischeri

        Xiang-Lan,Piao,Xiao-Yuan,Mi,Yan-Ze,Tian,Qian,Wu,Hui-Shan,Piao,Zhikai,Zeng,Xiangshu,Piao,Ding,Wang 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.12

        The objectives of this study were to investigate the radical-scavenging activity of Ligularia fischeri on oxidative damage by the radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) and to rapidly identify the active components using the bioassay-linked fractionation method. The MeOH extract and fractions of CH2Cl2, BuOH, and H2O from L. fischeri showed DPPH radical-scavenging effects in a dose-dependent manner (p < 0.01). In particular, the BuOH fraction had the most effective (p < 0.05) antioxidative capacity. The active constituents from the BuOH fraction of L. fischeri were rapidly isolated by bioassay-linked HPLC method and identified as hyperoside and 2''-acetylhyperoside with potent antioxidant effects against the DPPH radical, with IC50 values of 1.31 and 7.09 μg/mL, respectively. They have not been reported from L. fischeri yet. The objectives of this study were to investigate the radical-scavenging activity of Ligularia fischeri on oxidative damage by the radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) and to rapidly identify the active components using the bioassay-linked fractionation method. The MeOH extract and fractions of CH2Cl2, BuOH, and H2O from L. fischeri showed DPPH radical-scavenging effects in a dose-dependent manner (p < 0.01). In particular, the BuOH fraction had the most effective (p < 0.05) antioxidative capacity. The active constituents from the BuOH fraction of L. fischeri were rapidly isolated by bioassay-linked HPLC method and identified as hyperoside and 2''-acetylhyperoside with potent antioxidant effects against the DPPH radical, with IC50 values of 1.31 and 7.09 μg/mL, respectively. They have not been reported from L. fischeri yet.

      • KCI등재

        소비자 프라이버시 보호에 관한 다항식 기반 연구

        박연희(Yanji Piao), 김민지(Minji Kim) 한국IT서비스학회 2020 한국IT서비스학회지 Vol.19 No.1

        '스콜라' 이용 시 소속기관이 구독 중이 아닌 경우, 오후 4시부터 익일 오전 7시까지 원문보기가 가능합니다.

        With the development and widespread application of online shopping, the number of online consumers has increased. With one click of a mouse, people can buy anything they want without going out and have it sent right to the doors. As consumers benefit from online shopping, people are becoming more concerned about protecting their privacy. In the group buying scenario described in our paper, online shopping was regarded as intra-group communication. To protect the sensitive information of consumers, the polynomial-based encryption key sharing method (Piao et al., 2013; Piao and Kim, 2018) can be applied to online shopping communication. In this paper, we analyze security problems by using a polynomial-based scheme in the following ways : First, in Kamal's attack, they said it does not provide perfect forward and backward secrecy when the members leave or join the group because the secret key can be broken in polynomial time. Second, for simultaneous equations, the leaving node will compute the new secret key if it can be confirmed that the updated new polynomial is recomputed. Third, using Newton s method, attackers can successively find better approximations to the roots of a function. Fourth, the Berlekamp Algorithm can factor polynomials over finite fields and solve the root of the polynomial. Fifth, for a brute-force attack, if the key size is small, brute force can be used to find the root of the polynomial, we need to make a key with appropriately large size to prevent brute force attacks. According to these analyses, we finally recommend the use of a relatively reasonable hash-based mechanism that solves all of the possible security problems and is the most suitable mechanism for our application. The study of adequate and suitable protective methods of consumer security will have academic significance and provide the practical implications.

      • Prognostic Value of T Cell Immunoglobulin Mucin-3 in Prostate Cancer

        Piao,,Yong-Rui,Piao,,Long-Zhen,Zhu,,Lian-Hua,Jin,,Zhe-Hu,Dong,,Xiu-Zhe Asian Pacific Organization for Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

        Background: Optimal treatment for prostate cancer remains a challenge worldwide. Recently, T cell immunoglobulin mucin-3 (TIM-3) has been implicated in tumor biology but its contribution prostate cancer remains unclear. The aim of this study was to investigate the role of TIM-3 as a prognostic marker in patients with prostate cancer. Methods: TIM-3 protein expression was determined by immunohistochemistry and Western blotting in 137 prostate cancer tumor samples and paired adjacent benign tissue. We also performed cell proliferation assays using 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl- 2H tetrazolium bromide (MTT) and cell invasion assays. The effects of small interfering RNA (siRNA)-mediated knockdown of TIM-3 (TIM-3 siRNA) in two human prostate cancer cell lines were also evaluated. Results: TIM-3 expression was higher in prostate cancer tissue than in the adjacent benign tissue (P<0.001). High TIM-3 expression was an independent predictor of both recurrence-free survival and progression-free survival. TIM-3 protein was expressed in both prostate cancer cell lines and knockdown suppressed their proliferation and invasion capacity. Conclusions: TIM-3 expression is associated with a poor prognosis in prostate cancer. Taken together, our resutlts indicate that TIM-3 is a potential prognostic marker in prostate cancer.

      • SCIESCOPUSKCI등재

        Full Color Holographic Optical Element Fabrication for Waveguide-type Head Mounted Display Using Photopolymer

        Piao,,Jing-Ai,Li,,Gang,Piao,,Mei-Lan,Kim,,Nam Optical Society of Korea 2013 Journal of the optical society of Korea Vol.17 No.3

        Full color holographic optical element fabrication using a photopolymer is proposed for a waveguide-type head mounted display. The fabricated full color holographic optical elements can be attached to the waveguide to replace the conventional couple-in and couple-out optics in the head mounted display. To implement the system, this study analyzed the optical characteristics of the photopolymer using three lasers (red, green and blue). Considering the color uniformity, a new laminated structure for a full color holographic optical element was also designed. The proposed system was confirmed experimentally.

      • KCI등재후보

        Analysis of the Factors Influencing Consumers' Preferences for Rice: Locally Produced Versus the Imported in the Ga East Municipality of the Greater Accra Region of Ghana

        ( Piao¸ S. Y. ), ( Z. R. Li ), ( Y. C. Sun ), ( J. I. Lee ), ( Y. E. Amanor ) 강원대학교 농업생명과학연구원(구 농업과학연구소) 2020 강원 농업생명환경연구 Vol.32 No.S

        Rice is an important staple cereal for many households in Ghana. This study examines the factors that influence consumers' preference for rice. Using questionnaires, 300 rice consumers, who were sampled across the municipality, were interviewed. Descriptive statistics, factor analysis, and multinomial logistic regression model were used to analyze the obtained data. The rice-related attributes that showed marked influence on consumers' preference for rice were packaging quality, swelling capacity, stickiness of grains after cooking, percentage of broken grains, market availability, price, and degree of whiteness. Therefore, the stakeholders should implement strategies to improve these rice-related attributes and enhance the rice post-harvest chain.

      • KCI등재

        평양시 삼석구역 호남리에서 새롭게 조사된 고구려 석실봉토묘의 발굴정형에 대하여

        박찬규(Piao, Can Kui), 정경일(Zheng, Jingri) 건국대학교 인문학연구원 2014 통일인문학 Vol.60 No.-

        2013년 10월, 북한사회과학원 고고학연구소에서는 평양시 삼석구역 호남리에서 호남리 19호, 20호, 21호 등 고구려시기 석실봉토묘 3기를 새롭게 발굴정리하였다. 발굴조사 일부 기간에 중국 연변대학 인문사회과학학원 역사학부 박찬규, 정경일 교수가 참가하였다. 호남리 19호 무덤은 안길과 주검칸으로 이루어진 지상식 석실봉토단실묘이다. 안길은 주검칸의 남벽 중심에서 남쪽으로 길게 나 있다. 주검칸의 입구에는 장방형의 막음돌이 세워져 있고 막음돌의 안쪽에는 문턱시설이나 있다. 주검칸의 평면생김새는 남북으로 긴 장방형인데 주검칸 가운데에는 평면이 장방형인 관대시설이 남북으로 길게 놓여있다. 이 무덤에서는 머리가 없는 못대가 1점 나왔다. 무덤의 축조시기는 6세기로 보인다. 호남리 20호 무덤은 안길과 주검칸으로 이루어진 지상식의 단실묘이다. 안길은 주검칸 남벽 중심에서 남쪽으로 길게 나 있다. 주검칸의 평면생김새는 남북으로 긴 장방형인데 주검칸 입구에는 장방형의 문턱시설이 있다. 주검칸의 동, 서 양쪽에는 배수시설이 있으며 바닥에는 관대가 설치되어 있다. 유물로는 쇠로 만든 관못이 16점 드러났다. 무덤의 축조시기는 19호 무덤과 같은 시기인 6세기이다. 호남리 21호 무덤은 안길과 주검칸으로 이루어진 반지하식의 석실봉토단실묘이다. 주검칸의 평면생김새는 방형에 가까운 장방형인데 주검칸에서는 관대시설을 찾아볼 수 없었다. 유물로 4점의 쇠관못이 드러났다. 무덤의 축조시기는 그 구조로 보아 5~6세기의 것으로 판단된다. 이번에 발굴된 무덤가운데서 호남리 19호, 20호 무덤은 고구려시기의 석실봉토묘의 유형을 더욱 세분화할 필요성을 안겨주는 귀중한 자료이다. 특히 20호 무덤에서는 지금까지 볼 수 없었던 가로 놓인 관받침과 같은 시설이 나타난 것은 고구려 무덤형식에서는 보기 드문 것으로서 고구려 석실봉토묘 구조의 다양성을 보여주는 또 하나의 실례라고 말할 수 있다. In October 2013, The North Korean Academy of Social Sciences Institute of Archaeology discovered three Koguryo stone chamber tombs, including Tomb No.19, Tomb No.20 and Tomb No.21 in Hunan Lane. During the investigation, Piao Cankui and Zheng Jingri, two professor from the Department of History of Yanbian University in China took part in this excavation. Tomb No.19 in Hunan Lane is a stone chamber tombwhich is on the ground with a single room. It is made up of a tomb passage and a burial room. The tomb passage is located at the central part of south wall of the burial room. There is a rectangular obturating stone at the entrance of the burial room and also a threshold inside the obturating stone. Tombshape,and the north-south direction is longer than the east-west direction. A rectangular platform lies at the central of the tomb, with the both ends facing north and south respectively. One coffin was excavated in the tombbut only the body was found.Tomb No.19 in Hunan Lane existed in about the 6th Century. Tomb No.20 in Hunan Lane is a single chamber tomb which is on the ground. It is made up of a tomb passage and a burial room. The tomb passage is located at the central part of south wall of the burial room.The tomb passage is located at the central part of south wall of the burial room. The tomb passage is located at the central part of south wall of burial rooms. A threshold laid inside the entrance in burial rooms, also there are drainage facilities on both sides in the room and a coffin platform on the ground. Sixteen iron coffins were excavated in the tomb. Tomb No.20 in Hunan Lane also existed in aboutthe 6th Century as Tomb No.19. Tomb No.21 in Hunan Lane is a stone chamber tomb which is Half underground with a single room. It is made up of a tomb passage and a burial room. The tombshape, and there was no coffin platform on the ground. Four iron coffinnails were excavated in the tomb. Tomb No.21 in Hunan Lane existed in around the 5th to 6th Century. The excavation of these three tombs in Hunan Lane provided valuable information for further subdivision of the type of Koguryo stone chamber tombs. In particular, there are several thwart pad stones under the coffin platform that is extremely rare in Koguryo mausoleum, which provided new substantial information for further research about the structure of Koguryo stone chamber tomb.

      • KCI등재

        Pharmacokinetic study of mucoadhesive metformin pellets in rats

        Jingshu,Piao,Ji-Eun,Lee,신대환,김진석 한국약제학회 2012 Journal of Pharmaceutical Investigation Vol.42 No.03

        Previously, we have reported the preparation and characterization of mucoadhesive pellets of metformin hydrochloride using four high-viscosity polymers including hydroxymethylcellulose (HPMC), HPMC/carbopol, sodium carboxylmethylcellulose (Na-CMC) and sodium alginate (Na-Alg) (Piao et al., Arch Pharm Res 32:391–397, 2009). Here, pharmacokinetic and pharmacodynamic evaluation of these metformin pellets was performed. Metformin pellets were administered orally to normal and streptozotocininduced diabetic rats at 100 mg/kg dose and the blood concentration of metformin and blood glucose levels were determined. The area under the plasma concentration versus time curve from the Na-Alg-coated metformin pellets in normal rats was 69.93 ± 39.63 lg h/mL and it was the highest among tested, followed by Na-CMC-coated pellets (58.38 ± 5.19), HPMC/carbopol-coated pellets (52.24 ±5.29), HPMC-coated pellets (42.70 ± 14.29) and metformin aqueous solution (33.49 ± 2.04). The Cmax from the Na-Alg-coated metformin pellets in normal rats was 29.47 ±10.74 lg/mLand itwas the highest among tested, followed by Na-CMC-coated pellets (15.10 ± 2.73), HPMC/carbopolcoated pellets (11.38 ± 3.04), HPMC-coated pellets (11.29 ± 3.85) and metformin aqueous solution (6.92 ±0.83). The area under the effect versus time curve of the Na-Alg-coated pellets in diabetic rats was the highest as 670.01 ± 211.20 lg h/mL, followed by CMC-coated pellets (542.42 ± 116.93), HPMC-coated pellets (539.46 ±189.91), HPMC/carbopol-coated pellets (444.03 ± 90.30),and metformin aqueous solution (199.28 ± 31.07). These data show that the Na-Alg-coated pellets were found to be the best among tested as a new mucoadhesive formulation for metformin hydrochloride prepared by the powder layering technique with a centrifugal fluidizing-granulator.

      • 의사결정 트리 앙상블을 구축하기 위한 상관성 기반 기법을 이용한 속성 중복성 제거

        박영준 ( Yongjun Piao ), 박명호 ( Minghao Piao ), 손호선 ( Ho Sun Shon ), 류근호 ( Keun Ho Ryu ) 한국정보처리학회 2011 한국정보처리학회 학술대회논문집 Vol.18 No.2

        대량의 분류 규칙 탐사 과정은 앙상블기법을 사용하여 다양한 연구들이 이루어지고 있다. 본 논문에서는 의사결정 트리의 분열 문제와 singleton 포함 한계를 해결하기 위하여 Cascading-and-Sharing 앙상블 기법을 적용하여 점진적 다중 의사결정 트리를 구축하였다. 또한 분류의 정확도를 향상시키고, 트리의 복잡도와 모델 과잉접합을 피하기 위하여 다중 트리 구축과정에서 선형 상관분석기법을 기반으로 훈련 데이터 속성들의 중복성을 제거하였다. 실험 결과, 속성들의 중복성을 제거하여 구축한 트리들은 원래 기법보다 더 좋은 결과를 보여주었다.

      • KCI등재SCOPUS

        Full Color Holographic Optical Element Fabrication for Waveguide-type Head Mounted Display Using Photopolymer

        Jing-Ai,Piao,Gang,Li,Mei-Lan,Piao,김남 한국광학회 2013 Journal of the optical society of Korea Vol.17 No.3

        Full color holographic optical element fabrication using a photopolymer is proposed for a waveguide-type head mounted display. The fabricated full color holographic optical elements can be attached to the waveguide to replace the conventional couple-in and couple-out optics in the head mounted display. To implement the system, this study analyzed the optical characteristics of the photopolymer using three lasers (red, green and blue). Considering the color uniformity, a new laminated structure for a full color holographic optical element was also designed. The proposed system was confirmed experimentally.

      • SCOPUSKCI등재

        Chemical Constituents of the Fruit of Citrus junos

        Kim,,Bak,Kwang,Park,,Jeong,Hill,Park,,Man,Ki,Cho,,Eun,Jung,Piao,,Hui,Shan,Piao,,Xiang,Lan,Piao,,Long,Zhu 한국생약학회 2000 Natural Product Sciences Vol.6 No.4

        Nine compounds were isolated from the fruit of Citrus junos. Their structures were elucidated as 9-hydroxy-4-methoxypsoralen, auraptene, limonin, deacetylnomilin, cirsimaritin, narirutin, naringin, hesperidin and neohesperidin by physico-chemical evidences. 9-Hydroxy-4-methoxypsoralen and auraptene have not been reported from C. junos yet.

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