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RISS 인기검색어
- 검색키워드
- 저자 : Pezhman Sasanpour (검색결과 3 건)
- 무료
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PEZHMAN SASANPOUR,BABAK RASHIDIAN,BIZHAN RASHIDIAN,MANOUCHEHR VOSSOUGHI 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2010 NANO Vol.5 No.6
A novel approach for phototherapy is proposed. The proposed method is based on cell apoptosis according to halting activation of cancer cell membrane receptor by exposure to UV light pulses without any side effect. In the proposed method, gold nanoparticles are directed to cancerous cells by conjugating their surface with specific ligands. UV light is created locally adjacent to cells around the gold nanoparticles. UV light is generated due to nonlinear interaction of visible light with gold nanoparticles because of enhancement in third order nonlinear effects. For example, by using 780 nm laser, 260 nm UV will be generated around the nanoparticle because of third harmonic generation process. As the generated UV is localized around the cell, there will be no side effect for other cells. We have numerically analyzed the proposed method by solving Maxwell's equation considering third order nonlinear susceptibility and dispersion behavior of permittivity by 3D nonlinear finite difference time domain using Newton–Raphson method. Simulation results for different geometries show that UV light will be generated around gold nanoparticle and it is maximum in hot spots where electric field enhancement occurs. Simulation results illustrate that there is neither UV irradiation side effect to healthy cells, nor harmful temperature rise.
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Neurophysiological Effect of External Electromagnetic Field: A Computational Modeling
Tahereh Tekieh,Pezhman Sasanpour,Hashem Ra¯i-Tabar 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.10
The effect of an alternating external field on the pattern of an axon's action potential and its propagation has been investigated by incorporating the effect of an alternating electric field in the nonlinear Hodgkin–Huxley cable model. The results illustrate that for a wide range of frequencies, the applied field is capable of stimulating the resting potential of the membrane. In addition to hyper-polarization state of the neuron which is inevitable for certain values of the electric field amplitude, there will be additional effects on the propagation of action potentials in the neuron. We have also studied the action potentials velocity and amplitude change in the presence of the external field while the fiber is firing. The initiation of action potential for an axon at rest exposed to external field is possible and during the firing of the neuron and under the influence of the external field, it will act as a velocity modifier, and the neuron will lower the amplitude of the action potentials.
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Are deformed neurons electrophysiologically altered? A simulation study
Tahereh Tekieh,Sohrab Shahzadi,Hashem Rafii-Tabar,Pezhman Sasanpour 한국물리학회 2016 Current Applied Physics Vol.16 No.10
The electrophysiological outcome of neuron deformation is studied. This study is based on modeling the propagation of action potentials in a neuron with different deformed segments subject to an external mechanical compression. The proposed model is based on modified cable equation incorporating geometry variations. The study is performed for different degrees and number of deformations of the axon structure. The results of simulation show that the propagation speed, the refractory period, and the action potential broadening are all directly affected by variations in the geometry.
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