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RISS 인기검색어
- 검색키워드
- 저자 : Petra Wilder-Smith (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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안예찬(Yeh-Chan Ahn),Petra Wilder-Smith,Zhongping Chen 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11
The specific aims of this work are to point out the uniqueness of Doppler optical coherence tomography (DOCT) as a novel probe station for (in vivo) microscale flow and structure visualization and to maximize the capability of DOCT by overcoming its limitation. Conventional DOCT images only one of the velocity components which is parallel to incident light. A multi-angle DOCT to quantify a velocity vector field, here, is proposed which is an extension from one- to three-dimensional velocity field. A pulsating three-dimensional velocity field is another challenge due to limited frame rate. In vivo pulsating blood flow is measured by using an electrocardiogram-gated multi-angle DOCT in a hamster cheek pouch model. It is shown that aliasing problem caused by relatively low frame rate is resolved.
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Kim Chang Soo,Ingato Dominique,Wilder-Smith Petra,Chen Zhongping,Kwon Young Jik 나노기술연구협의회 2018 Nano Convergence Vol.5 No.3
A key design consideration in developing contrast agents is obtaining distinct, multiple signal changes in diseased tissue. Plasmonic gold nanoparticles (Au NPs) have been developed as contrast agents due to their strong surface plasmon resonance (SPR). This study aims to demonstrate that stimuli-responsive plasmonic Au nanoclusters (Au NCs) can be used as a contrast agent for optical coherence tomography (OCT) in detecting early-stage cancer. Au NPs were clustered via acid-cleavable linkers to synthesize Au NCs that disassemble under mildly acidic conditions into individual Au NPs, simultaneously diminishing SPR effect (quantified by scattering intensity) and increasing Brownian motion (quantified by Doppler variance). The acid-triggered morphological and accompanying optico-physical property changes of the acid-disassembling Au NCs were confirmed by TEM, DLS, UV/Vis, and OCT. Stimuli-responsive Au NCs were applied in a hamster check pouch model carrying early-stage squamous carcinoma tissue. The tissue was visualized by OCT imaging, which showed reduced scattering intensity and increased Doppler variance in the dysplastic tissue. This study demonstrates the promise of diagnosing early-stage cancer using molecularly programmable, inorganic nanomaterial-based contrast agents that are capable of generating multiple, stimuli-triggered diagnostic signals in early-stage cancer.
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Multimodality approach to optical early detection and??? mapping of oral neoplasia.
Ahn, Yeh-Chan,Chung, Jungrae,Wilder-Smith, Petra,Chen, Zhongping SPIE--the International Society for Optical Engine 2011 JOURNAL OF BIOMEDICAL OPTICS Vol.16 No.7
<P>Early detection of cancer remains the best way to ensure patient survival and quality of life. Squamous cell carcinoma is usually preceded by dysplasia presenting as white, red, or mixed red and white epithelial lesions on the oral mucosa (leukoplakia, erythroplakia). Dysplastic lesions in the form of erythroplakia can carry a risk for malignant conversion of 90%. A noninvasive diagnostic modality would enable monitoring of these lesions at regular intervals and detection of treatment needs at a very early, relatively harmless stage. The specific aim of this work was to test a multimodality approach [three-dimensional optical coherence tomography (OCT) and polarimetry] to noninvasive diagnosis of oral premalignancy and malignancy using the hamster cheek pouch model (nine hamsters). The results were compared to tissue histopathology. During carcinogenesis, epithelial down grow, eventual loss of basement membrane integrity, and subepithelial invasion were clearly visible with OCT. Polarimetry techniques identified a four to five times increased retardance in sites with squamous cell carcinoma, and two to three times greater retardance in dysplastic sites than in normal tissues. These techniques were particularly useful for mapping areas of field cancerization with multiple lesions, as well as lesion margins.</P>
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