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Assessment of London underground tube tunnels - investigation, monitoring and analysis
Wright, Peter Techno-Press 2010 Smart Structures and Systems, An International Jou Vol.6 No.3
Tube Lines has carried out a "knowledge and investigation programme" on the deep tube tunnels comprising the Jubilee, Northern and Piccadilly lines, as required by the PPP contract with London Underground. Many of the tunnels have been in use for over 100 years, so this assessment was considered essential to the future safe functioning of the system. This programme has involved a number of generic investigations which guide the assessment methodology and the analysis of some 5,000 individual structures. A significant amount of investigation has been carried out, including ultrasonic thickness measurement, detection of brickwork laminations using radar, stress measurement using magnetic techniques, determination of soil parameters using CPT, pressuremeter and laboratory testing, installation of piezometers, material and tunnel segment testing, and trialling of remote photographic techniques for inspection of large tunnels and shafts. Vibrating wire, potentiometer, electro level, optical and fibre-optic monitoring has been used, and laser measurement and laser scanning has been employed to measure tunnel circularity. It is considered that there is scope for considerable improvements in non-destructive testing technology for structural assessment in particular, and some ideas are offered as a "wish-list". Assessment reports have now been produced for all assets forming Tube Lines' deep tube tunnel network. For assets which are non-compliant with London Underground standards, the risk to the operating railway has to be maintained as low as reasonably practicable (ALARP) using enhanced inspection and monitoring, or repair where required. Monitoring techniques have developed greatly during recent years and further advances will continue to support the economic whole life asset management of infrastructure networks.
Assessment of London underground tube tunnels - investigation, monitoring and analysis
Peter Wright 국제구조공학회 2010 Smart Structures and Systems, An International Jou Vol.6 No.3
Tube Lines has carried out a knowledge and investigation programme on the deep tube tunnels comprising the Jubilee, Northern and Piccadilly lines, as required by the PPP contract with London Underground. Many of the tunnels have been in use for over 100 years, so this assessment was considered essential to the future safe functioning of the system. This programme has involved a number of generic investigations which guide the assessment methodology and the analysis of some 5,000 individual structures. A significant amount of investigation has been carried out, including ultrasonic thickness measurement, detection of brickwork laminations using radar, stress measurement using magnetic techniques, determination of soil parameters using CPT, pressuremeter and laboratory testing, installation of piezometers, material and tunnel segment testing, and trialling of remote photographic techniques for inspection of large tunnels and shafts. Vibrating wire, potentiometer, electro level, optical and fibre-optic monitoring has been used, and laser measurement and laser scanning has been employed to measure tunnel circularity. It is considered that there is scope for considerable improvements in non-destructive testing technology for structural assessment in particular, and some ideas are offered as a wish-list. Assessment reports have now been produced for all assets forming Tube Lines deep tube tunnel network. For assets which are non-compliant with London Underground standards, the risk to the operating railway has to be maintained as low as reasonably practicable (ALARP) using enhanced inspection and monitoring, or repair where required. Monitoring techniques have developed greatly during recent years and further advances will continue to support the economic whole life asset management of infrastructure networks.
Cameron Wright,Pietari Mäkelä,Alexandre Bigot,Mikael Anttinen,Peter J. Boström,Roberto Blanco Sequeiros 대한의용생체공학회 2023 Biomedical Engineering Letters (BMEL) Vol.13 No.1
The non-perfused volume (NPV) is an important indicator of treatment success immediately after prostate ablation. However, visualization of the NPV first requires an injection of MRI contrast agents into the bloodstream, which has many downsides. Purpose of this study was to develop a deep learning model capable of predicting the NPV immediately after prostate ablation therapy without the need for MRI contrast agents. A modified 2D deep learning UNet model was developed to predict the post-treatment NPV. MRI imaging data from 95 patients who had previously undergone prostate ablation therapy for treatment of localized prostate cancer were used to train, validate, and test the model. Model inputs were T1/T2-weighted and thermometry MRI images, which were always acquired without any MRI contrast agents and prior to the final NPV image on treatment-day. Model output was the predicted NPV. Model accuracy was assessed using the Dice-Similarity Coefficient (DSC) by comparing the predicted to ground truth NPV. A radiologist also performed a qualitative assessment of NPV. Mean (std) DSC score for predicted NPV was 85% ± 8.1% compared to ground truth. Model performance was significantly better for slices with larger prostate radii (> 24 mm) and for whole-gland rather than partial ablation slices. The predicted NPV was indistinguishable from ground truth for 31% of images. Feasibility of predicting NPV using a UNet model without MRI contrast agents was clearly established. If developed further, this could improve patient treatment outcomes and could obviate the need for contrast agents altogether. Trial Registration Numbers Three studies were used to populate the data: NCT02766543, NCT03814252 and NCT03350529.
Super-Eddington Accretion in the <i>WISE</i>-selected Extremely Luminous Infrared Galaxy W2246−0526
Tsai, Chao-Wei,Eisenhardt, Peter R. M.,Jun, Hyunsung D.,Wu, Jingwen,Assef, Roberto J.,Blain, Andrew W.,Dí,az-Santos, Tanio,Jones, Suzy F.,Stern, Daniel,Wright, Edward L.,Yeh, Sherry C. C. American Astronomical Society 2018 The Astrophysical journal Vol.868 No.1
MINERVA: SMALL PLANETS FROM SMALL TELESCOPES
WITTENMYER, ROBERT A.,JOHNSON, JOHN ASHER,WRIGHT, JASON,MCCRADY, NATE,SWIFT, JONATHAN,BOTTOM, MICHAEL,PLAVCHAN, PETER,RIDDLE, REED,MUIRHEAD, PHILIP S.,HERZIG, ERICH,MYLES, JUSTIN,BLAKE, CULLEN H.,EAST The Korean Astronomical Society 2015 天文學論叢 Vol.30 No.2
The Kepler mission has shown that small planets are extremely common. It is likely that nearly every star in the sky hosts at least one rocky planet. We just need to look hard enough-but this requires vast amounts of telescope time. MINERVA (MINiature Exoplanet Radial Velocity Array) is a dedicated exoplanet observatory with the primary goal of discovering rocky, Earth-like planets orbiting in the habitable zone of bright, nearby stars. The MINERVA team is a collaboration among UNSW Australia, Harvard-Smithsonian Center for Astrophysics, Penn State University, University of Montana, and the California Institute of Technology. The four-telescope MINERVA array will be sited at the F.L. Whipple Observatory on Mt Hopkins in Arizona, USA. Full science operations will begin in mid-2015 with all four telescopes and a stabilised spectrograph capable of high-precision Doppler velocity measurements. We will observe ~100 of the nearest, brightest, Sun-like stars every night for at least five years. Detailed simulations of the target list and survey strategy lead us to expect $15{\pm}4$ new low-mass planets.
Immigration, Trade Costs and Trade: Gravity Evidence for Greece
( Andromachi S. Piperakis ),( Chris Milner ),( Peter W. Wright ) 세종대학교 경제통합연구소 (구 세종대학교 국제경제연구소) 2003 Journal of Economic Integration Vol.18 No.4
This paper investigates the influence of immigration into Greece on the volumes of Greeces bilateral trade using a gravity modelling approach. An augmented gravity model is estimated using a panel data set for the period 1981-1991. The results show that immigration had a positive impact on the volume of Greeces bilateral exports, but no effect on its bilateral imports. This is consistent with immigration reducing transactions or trading costs on Greeces exports.
Shichao Zhao,David Kirk,Simon Bowen,Peter Wright 국립민속박물관 2019 International Journal of Intangible Heritage Vol.14 No.-
The digital heritage sector has become a highly significant part of the development of cultural heritage. Cultural organisations are increasingly using interactive technology to support the understanding of cultural heritage. This research aims to provide an approach for digital cultural heritage researchers and digital museologists to establish an appropriate position within digital cultural heritage. In this paper, the authors have undertaken a qualitative evaluation of data based on interviews, workshops and fieldwork focusing on potential transcultural audiences, and Chinese/non- Chinese puppetry stakeholders. From these findings, the authors have presented several design suggestions for cultural preservation to surmount transcultural barriers.
Detection of Polarized Infrared Emission by Polycyclic Aromatic Hydrocarbons in the MWC 1080 Nebula
Zhang, Han,Telesco, Charles M.,Hoang, Thiem,Li, Aigen,Pantin, Eric,Wright, Christopher M.,Li, Dan,Barnes, Peter American Astronomical Society 2017 The Astrophysical journal Vol.844 No.1
<P>Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous in astrophysical environments, as revealed by their pronounced emission features at 3.3, 6.2, 7.7, 8.6, 11.3, and 12.7 mu m commonly ascribed to the C-H and C-C vibrational modes. Although these features have long been predicted to be polarized, previous searches for PAH polarization led to null or, at best, tentative detections. Here we report the definite detection of polarized PAH emission at 11.3 mu m in the nebula associated with the Herbig Be star MWC 1080. We measure a polarization degree of 1.9% +/- 0.2%, which is unexpectedly high compared to models. This poses a challenge in the current understanding of the alignment of PAHs, which is required to polarize the PAH emission but thought to be substantially suppressed. PAH alignment with a magnetic field via a resonance paramagnetic relaxation process may account for such a high level of polarization.</P>
Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2.
Ferreon, Josephine C,Lee, Chul Won,Arai, Munehito,Martinez-Yamout, Maria A,Dyson, H Jane,Wright, Peter E National Academy of Sciences 2009 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.106 No.16
<P>The tumor suppressor activity of p53 is regulated by interactions with the ubiquitin ligase HDM2 and the general transcriptional coactivators CBP and p300. Using NMR spectroscopy and isothermal titration calorimetry, we have dissected the binding interactions between the N-terminal transactivation domain (TAD) of p53, the TAZ1, TAZ2, KIX, and nuclear receptor coactivator binding domains of CBP, and the p53-binding domain of HDM2. The p53 TAD contains amphipathic binding motifs within the AD1 and AD2 regions that mediate interactions with CBP and HDM2. Binding of the p53 TAD to CBP domains is dominated by interactions with AD2, although the affinity is enhanced by additional interactions with AD1. In contrast, binding of p53 TAD to HDM2 is mediated primarily by AD1. The p53 TAD can bind simultaneously to HDM2 (through AD1) and to any one of the CBP domains (through AD2) to form a ternary complex. Phosphorylation of p53 at T18 impairs binding to HDM2 and enhances affinity for the CBP KIX domain. Multisite phosphorylation of the p53 TAD at S15, T18, and S20 leads to increased affinity for the TAZ1 and KIX domains of CBP. These observations suggest a mechanism whereby HDM2 and CBP/p300 function synergistically to regulate the p53 response. In unstressed cells, CBP/p300, HDM2 and p53 form a ternary complex that promotes polyubiquitination and degradation of p53. After cellular stress and DNA damage, p53 becomes phosphorylated at T18 and other residues in the AD1 region, releases HDM2 and binds preferentially to CBP/p300, leading to stabilization and activation of p53.</P>