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RISS 인기검색어
- 검색키워드
- 저자 : Pengmin Lu (검색결과 5 건)
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Research on rib-to-diaphragm welded connection by means of hot spot stress approach
Binhua Wang,Pengmin Lu,Yuhong Shao 국제구조공학회 2015 Steel and Composite Structures, An International J Vol.18 No.1
The cutout hole locating at the place of rib-to-diaphragm welded connection is adopted to minimize the restraint, which is caused by the floor-beam web to rib rotation at the support due to the unsymmetrical loads in orthotropic deck. In practice, an inevitable problem is that there is a large number of welding joint's cracks formed at the edge of cutout hole. In this study, a comparative experiment is carried out with two types of cutout hole, the circular arc transition and the vertical transition. The fatigue life estimation of specimens is investigated with the application of the structural hot spot stress approach by finite element analyses. The results are compared with the ones of the fatigue tests which are carried out on these full-scale specimens. Factors affecting the stress range are also studied.
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Qingyi Xiang,Pengmin Lu,Binhua Wang 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.12
A new strain gauge layout method on the structural surface is proposed to identify the six-component loads in cross-section. Numerical simulation of a cantilever beam and an industrial case study, i.e., identification of hinge joint loads on excavator working device under actual excavating condition, are presented to demonstrate the practicability of the proposed method for industrial scale problems. The hinge joint loads deduced from the stick’s sixcomponent cross-section loads identified by the new method were compared with the values calculated by traditional method, and the recurrence degree of stress and fatigue cumulative damage of the stick’s fatigue critical points were also compared. The maximum deviation between the actual damage of each selected measuring point and the damage caused by the identified hinge joint loads was only 1.69 %. The field test results showed that the new method could be conveniently applied with high identification accuracy for complicated actual loads.
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Ma Bing,Hu Yongtao,Lu Pengmin,Liu Yonggang 한국CDE학회 2023 Journal of computational design and engineering Vol.10 No.1
As science and technology improve, more and more complex global optimization difficulties arise in real-life situations. Finding the most perfect approximation and optimal solution using conventional numerical methods is intractable. Metaheuristic optimization approaches may be effective in achieving powerful global optimal solutions for these complex global optimization situations. Therefore, this paper proposes a new game-based algorithm called the running city game optimizer (RCGO), which mimics the game participant’s activity of playing the running city game. The RCGO is mathematically established by three newfangled search strategies: siege, defensive, and eliminated selection. The performance of the proposed RCGO algorithm in optimization is comprehensively evaluated on a set of 76 benchmark problems and 8 engineering optimization scenarios. Statistical and comparative results show that RCGO is more competitive with other state-of-the-art competing approaches in terms of solution quality and convergence efficiency, which stems from a proper balance between exploration and exploitation. Additionally, in the case of engineering optimization scenarios, the proposed RCGO is able to deliver superior fitting and occasionally competitive outcomes in optimization applications. Thus, the proposed RCGO is a viable optimization tool to easily and efficiently handle various optimization problems.
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Specific Mutations in APC, with Prognostic Implications in Metastatic Colorectal Cancer
Huan Peng,Jun Ying,Jia Zang,Hao Lu,Xiaokai Zhao,Pengmin Yang,Xintao Wang,Jieyi Li,Ziying Gong,Daoyun Zhang,Zhiguo Wang 대한암학회 2023 Cancer Research and Treatment Vol.55 No.4
Purpose Loss-of-function mutations in the adenomatous polyposis coli (APC) gene are common in metastatic colorectal cancer (mCRC). However, the characteristic of APC specific mutations in mCRC is poorly understood. Here, we explored the clinical and molecular characteristics of N-terminal and C-terminal side APC mutations in Chinese patients with mCRC. Materials and Methods Hybrid capture-based next-generation sequencing was performed on tumor tissues from 275 mCRC pati-ents to detect mutations in 639 tumor-associated genes. The prognostic value and gene-pathway difference between APC specific mutations in mCRC patients were analyzed. Results APC mutations were highly clustered, accounting for 73% of all mCRC patients, and most of them were truncating mutations. The tumor mutation burden of the N-terminal side APC mutations group (n=76) was significantly lower than that of the C-terminal side group (n=123) (p < 0.001), further confirmed by the public database. Survival analysis showed that mCRC patients with N-terminus side APC mutations had longer overall survival than C-terminus side. Tumor gene pathway analysis showed that gene mutations in the RTK/RAS, Wnt and transforming growth factor β signaling pathways of the C-terminal group were significantly higher than those of the N-terminal group (p < 0.05). Additionally, KRAS, AMER1, TGFBR2, and ARID1A driver mutations were more common in patients with C-terminal side APC mutations. Conclusion APC specific mutations have potential function as mCRC prognostic biomarkers. There are obvious differences in the gene mutation patterns between the C-terminus and N-terminus APC mutations group, which may have certain guiding significance for the subsequent precise treatment of mCRC.
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Cloning and functional characterization of two GsSnRK1 gene promoters from wild soybean
Chen Jun,Li Qiang,Zhang Pengmin,Lu Haoran,Bian Ya,Jian Yi,Wang Yizhu,Ding Xiaodong,Xiao Jialei 한국식물생명공학회 2021 Plant biotechnology reports Vol.15 No.5
Sucrose non-fermenting-related protein kinase 1 (SnRK1) belongs to a plant serine/threonine protein kinase family, and is part of a large interactive network of signaling pathways in plants to regulate many aspects of growth and development, and its gene expressions are highly responsive to multiple external stimuli. To functionally characterize the role of different SnRK1 members in wild soybean and identify the expression patterns of novel SnRK1 promoters for transgenic research, in this study, we performed an in silico analysis of the SnRK1 gene family in wild soybean and found GsSnRK1.1 and GsSnRK1.2 are main SnRK1 isoforms in wild soybean. The promoter fragments of both GsSnRK1.1 and GsSnRK1.2 were isolated, and a series of 5′-deletion and the full-length versions of both GsSnRK1.1 and GsSnRK1.2 promoters were fused with GUS reporter gene to generate expression vectors. The GUS activities in different tissues of seedling and adult growth stages of transgenic Arabidopsis plants were determined, and the GUS activities in transgenic Arabidopsis plants under NaCl, NaHCO3, PEG, ABA, MeJA and SA were also analyzed. The results showed that GsSnRK1.1 and GsSnRK1.2 genes have different expression patterns and both promoters may contain enhancers and silencers. In addition, NaCl, NaHCO3, ABA, MeJA, and PEG treatments enhanced, whereas SA treatment decreased the GUS activity under the control of both GsSnRK1.1 and GsSnRK1.2 promoters, which may be due to the distributions of various cis-elements in both GsSnRK1.1 and GsSnRK1.2 promoter regions. These results will contribute to a better understanding of the underlying mechanisms of GsSnRK1 genes in response to various abiotic stresses, and as stress-inducible promoters, GsSnRK1.1 and GsSnRK1.2 promoters can be candidates for practical application in agriculture.
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