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Elastic solutions due to a time-harmonic point load in isotropic multi-layered media
Gao Lin,Pengchong Zhang,Jun Liu,Wenyuan Wang 국제구조공학회 2016 Structural Engineering and Mechanics, An Int'l Jou Vol.57 No.2
A new analytical derivation of the elastodynamic point load solutions for an isotropic multilayered half-space is presented by means of the precise integration method (PIM) and the approach of dual vector. The time-harmonic external load is prescribed either on the external boundary or in the interior of the solid medium. Starting with the axisymmetric governing motion equations in a cylindrical coordinate system, a second order ordinary differential matrix equation can be gained by making use of the Hankel integral transform. Employing the technique of dual vector, the second order ordinary differential matrix equation can be simplified into a first-order one. The approach of PIM is implemented to obtain the solutions of the ordinary differential matrix equation in the Hankel integral transform domain. The PIM is a highly accurate algorithm to solve sets of first-order ordinary differential equations and any desired accuracy of the dynamic point load solutions can be achieved. The numerical simulation is based on algebraic matrix operation. As a result, the computational effort is reduced to a great extent and the computation is unconditionally stable. Selected numerical trials are given to validate the accuracy and applicability of the proposed approach. More examples are discussed to portray the dependence of the load-displacement response on the isotropic parameters of the multi-layered media, the depth of external load and the frequency of excitation.
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Ying Zhang,Hengyu Lei,Pengchong Wang,Qinyuan Zhou,Jie Yu,Xue Leng,Ruirui Ma,Danyang Wang,Kai Dong,Jianfeng Xing,Yalin Dong 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Reactive oxygen species (ROS) overproduction and excessive hypoxia play pivotal roles in the initiation and progression of ulcerative colitis (UC). Synergistic ROS scavenging and generating O2 could be a promising strategy for UC treatment. Methods Ceria nanozymes (PEG-CNPs) are fabricated using a modified reverse micelle method. We investigate hypoxia attenuating and ROS scavenging of PEG-CNPs in intestinal epithelial cells and RAW 264.7 macrophages and their effects on pro-inflammatory macrophages activation. Subsequently, we investigate the biodistribution, pharmacokinetic properties and long-term toxicity of PEG-CNPs in mice. PEG-CNPs are administered intravenously to mice with 2,4,6-trinitrobenzenesulfonic acid-induced colitis to test their colonic tissue targeting and assess their anti-inflammatory activity and mucosal healing properties in UC. Results PEG-CNPs exhibit multi-enzymatic activity that can scavenge ROS and generate O2, promote intestinal epithelial cell healing and inhibit pro-inflammatory macrophage activation, and have good biocompatibility. After intravenous administration of PEG-CNPs to colitis mice, they can enrich at the site of colonic inflammation, and reduce hypoxia-induced factor-1α expression in intestinal epithelial cells by scavenging ROS to generate O2, thus further promoting disrupted intestinal mucosal barrier restoration. Meanwhile, PEG-CNPs can effectively scavenge ROS in impaired colon tissues and relieve colonic macrophage hypoxia to suppress the pro-inflammatory macrophages activation, thereby preventing UC occurrence and development. Conclusion This study has provided a paradigm to utilize metallic nanozymes, and suggests that further materials engineering investigations could yield a facile method based on the pathological characteristics of UC for clinically managing UC.
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