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        Patient-Reported Outcomes Measurement Information System Physical Function Validation for Use in Anterior Cervical Discectomy and Fusion: A 2-Year Follow-up Study

        James M. Parrish,Nathaniel W. Jenkins,Elliot D.K. Cha,Conor P. Lynch,Cara E. Geoghegan,Shruthi Mohan,Caroline N. Jadczak,David P. Matichak,Kern Singh 대한척추신경외과학회 2021 Neurospine Vol.18 No.1

        Objective: Our study aims to evaluate the correlation of Patient-Reported Outcomes Measurement Information System physical function (PROMIS PF) with legacy patient-reported outcome measures (PROMs) among patients undergoing anterior cervical discectomy and fusion (ACDF). Methods: A prospectively maintained database was retrospectively reviewed for ACDF surgeries performed between May 2015 and September 2017. Inclusion criteria were primary elective, single- or multilevel ACDFs for degenerative spinal pathology. Patients lacking preoperative or 2-year PROMIS PF surveys were excluded. Mean scores were calculated for visual analogue scale (VAS) neck, VAS arm, Neck Disability Index (NDI), 12-Item Short Form Physical Component Score (SF-12 PCS), and PROMIS PF at preoperative and 6-week, 12-week, 6-month, 1-year, and 2-year postoperative timepoints. A t-test and Pearson correlation coefficient were utilized to evaluate score improvement and PROM relationships respectively. Results: The 50 subject cohort was 60.0% male, 50% obese (body mass index≥30 kg/m2) and had an average age of 50.9 years. Significant improvements were demonstrated for VAS neck and NDI at all postoperative timepoints (p<0.001) and for SF-12 and PROMIS PF at all timepoints except 6 weeks (p≤0.025). VAS arm improvement was seen up to 1 year (p≤0.016). PROMIS PF demonstrated strong correlations with NDI and SF-12 PCS at all evaluated timepoints and with VAS neck at all postoperative timepoints except 6 weeks (all p<0.01). Conclusion: PROMIS PF was strongly correlated with pain, disability, and physical function up to 2 years for patients undergoing ACDF. Our results support the long-term validity of PROMIS PF for measurement of patient-reported physical function among ACDF cohorts.

      • KCI등재

        The Relationship Between Preoperative PROMIS Scores With Postoperative Improvements in Physical Function After Anterior Cervical Discectomy and Fusion

        James M. Parrish,Nathaniel W. Jenkins,Nadia M. Hrynewycz,Thomas S. Brundage,Kern Singh 대한척추신경외과학회 2020 Neurospine Vol.17 No.2

        Objective: Assess preoperative Patient-Reported Outcomes Measurement Information System (PROMIS) physical function (PF) scores and differences between preoperative and postoperative PROMIS-PF scores for patients undergoing anterior cervical discectomy and fusion (ACDF). Methods: After Institutional Review Board approval, a prospectively maintained surgical registry was retrospectively reviewed for elective spine surgeries of nontraumatic, degenerative pathology between 2015–2018. Inclusion criteria were primary or revision, single-level ACDF procedures. Multilevel procedures and patients without preoperative surveys were excluded. A preoperative PROMIS score cutoff of 35 divided patients into PROMIS-PF score categories (e.g. , ≥ 35.0, < 35.0). Categorical and continuous variables were evaluated with chi-square tests and t-tests. Linear regression analyzed PROMIS-PF score improvement. Results: Eighty-six patients were selected, the high and low PROMIS-PF subgroups only differed in mean age (49.1 vs. 41.3, p = 0.002). Significant differences in PROMIS-PF scores were observed among high and low preoperative PROMIS-PF score subgroups at 6 weeks (p = 0.006), 12 weeks (p = 0.006), and 6 months (p = 0.014). Mean differences between preoperative and postoperative PROMIS-PF scores were significantly different between the high and low PROMIS-PF subgroups at 6 weeks (p = 0.041) and 1 year (p = 0.038). A significant negative association was observed between preoperative PROMIS scores and magnitude of improvement at the 6-week postoperative time point (slope = -0.6291, p < 0.001). Conclusion: Patients with low preoperative PROMIS-PF scores demonstrated greater improvements at 6 weeks and 1 year. Clinicians should consider patients with low preoperative PROMIS-PF scores to be in the unique position to potentially experience larger postoperative improvement magnitudes than patients with higher preoperative PROMIS-PF scores.

      • KCI등재

        Effects of 2-m Air Temperature Assimilation and a New Near-Surface Observation Operator on the NCEP Gridpoint Statistical-Interpolation System

        이승재,David F. Parrish,박세영,Wan-Shu Wu,Steven J. Greybush,이우진,Steven J. Lord 한국기상학회 2011 Asia-Pacific Journal of Atmospheric Sciences Vol.47 No.4

        In this study, we assimilate 2-m air temperature data with the National Centers for Environmental Prediction (NCEP) regional Gridpoint Statistical Interpolation (GSI) using the WRF-NMM model forecast as a first guess. Single time analysis experiments are conducted to test the impact of 2-m air temperature data on the analysis system and the results are compared with the control run without using 2-m air temperature data. The effort is focused on understanding the characteristics of observation innovations of the 2-m air temperature data. Modifications to background errors and a simple test of nonlinear quality control are also considered. The incorporation of a comprehensive near-surface observation operator based on Monin-Obukhov similarity theory is described and tested for possible operational use with the NCEP regional GSI system. The results from this new forward operator are compared with those from the existing simple forward operator. According to the results, mesonet 2-m temperature data were found to have a considerable amount of outliers compared with other 2-m temperature data. The nighttime western and central US domains indicated a model warm bias. Stations with large innovations are distributed uniformly in the nighttime western and central domains,while they are mainly located in the large cities in the daytime eastern domain. The statistical analysis of observation innovations showed that introduction of the new forward model can reduce root-mean-square errors in observation increment statistics. The results of a short assimilation experiment indicate that the new forward operator can be employed as a short-term strategy for near-surface data assimilation in the NCEP

      • KCI등재

        Longitudinal Evaluation of Patient-Reported Outcomes Measurement Information System for Back and Leg Pain in Minimally Invasive Transforaminal Lumbar Interbody Fusion

        Nathaniel W. Jenkins,James M. Parrish,Nadia M. Hrynewycz,Thomas S. Brundage,Kern Singh 대한척추신경외과학회 2020 Neurospine Vol.17 No.4

        Objective: While visual analogue score (VAS) metrics are among the most universally adopted patient-reported outcome measures (PROMs), there is limited research on the influence of back and leg pain on the Patient-Reported Outcomes Measurement Information System (PROMIS) physical function (PF) scores. Here we assess the association of VAS back and VAS leg scores with PROMIS PF in the setting of minimally invasive transforaminal lumbar interbody fusion (MIS TLIF). Secondarily, we determine if PROMIS PF is more influenced by back or leg pain. Methods: A prospective surgical registry was reviewed from May 2015 to November 2018. Inclusion criteria were primary, single-level MIS TLIFs. We excluded multilevel procedures and patients without preoperative PROMs. Pre- and postoperative PROMIS PF, VAS back, and VAS leg scores were recorded at 6 weeks, 12 weeks, 6 months, and 1 year. A Pearson correlation evaluated PROMIS PF association with VAS back and VAS leg scores. A Fisher z-test compared correlations. Linear regression evaluated PROMIS with VAS back and VAS leg scores. Results: Our cohort was comprised of 146 subjects. 40.4% were female and the average age of 51 years. VAS back demonstrated a stronger correlation than VAS leg with PROMIS PF at all timepoints. PROMIS PF scores were negatively associated with both VAS back and VAS leg at all timepoints. Fisher z-test revealed VAS back to have a stronger correlation with PROMIS PF (p=0.025) than VAS leg. Conclusion: In the setting of MIS TLIF, physical function as evaluated by PROMIS PF, had a stronger correlation with VAS back than VAS leg at 6 months. This suggests that postoperative PROMIS PF scores may be more influenced by back pain than with leg pain.

      • KCI등재

        Association of Preoperative PROMIS Scores With Short-term Postoperative Improvements in Physical Function After Minimally Invasive Transforaminal Lumbar Interbody Fusion

        Nathaniel W. Jenkins,James M. Parrish,Thomas S. Brundage,Nadia M. Hrynewycz,Kern Singh 대한척추신경외과학회 2020 Neurospine Vol.17 No.2

        Objective: This study examines the associations between preoperative Patient-Reported Outcomes Measurement Information System (PROMIS) physical function (PF) score, measured by PROMIS-PF and the change between pre- and postoperative PROMIS-PF scores. Methods: A prospectively maintained surgical registry was retrospectively reviewed for spine surgeries between May 2015–June 2019. Inclusion criteria were primary, single-level minimally invasive transforaminal lumbar interbody fusions. Revisions, multilevel procedures, and patients missing preoperative surveys were excluded. Patients were grouped by preoperative PROMIS-PF scores of ≥ 35 and < 35, with higher scores indicating greater PF. A chi-squared and Student t-test were used to analyze categorical and continuous variables respectively. Linear regression evaluated the relationship of PROMIS-PF score improvement. Results: Of the 180 subjects, 84 were in the PROMIS-PF < 35 group which had more obese patients (p < 0.001) and more males (p = 0.001). Length of stay was greater for the PROMIS-PF < 35 group (36.2 hours vs. 28.7 hours, p = 0.014). PROMIS-PF and Oswestry Disability Index scores were significantly different between subgroups at all timepoints. PROMIS-PF < 35 cohort had larger postoperative PROMIS-PF improvements at 6 weeks (p = 0.008) and 12 weeks (p = 0.003). Linear regression demonstrated a negative association between preoperative PROMIS-PF scores and improvement at 6 weeks, 12 weeks, 6 months, and 2 years (p < 0.001). PROMIS-PF < 35 demonstrated significantly lower rate of achieving minimum clinically important difference at 6 months, otherwise no difference observed throughout the 2-year follow-up. Conclusion: Up to 6 months postoperatively, lower preoperative PROMIS-PF scores were associated with larger PROMIS-PF improvements. Understanding the relationship preoperative PROMIS-PF scores have with postoperative improvement may enable better patient counseling.

      • Energetic salts based on nitroiminotetrazole-containing acetic acid

        Joo, Young-Hyuk,Gao, Haixiang,Parrish, Damon A.,Cho, Soo Gyeong,Goh, Eun Mee,Shreeve, Jean'ne M. The Royal Society of Chemistry 2012 Journal of materials chemistry Vol.22 No.13

        <P>2-(5-Nitroiminotetrazol-1-yl)acetic acid (<B>4</B>) was synthesized from 100% nitric acid and ethyl 2-(5-aminotetrazol-1-yl)acetate (<B>2</B>), which was easily obtained by reaction of ethyl aminoacetate hydrochloride, sodium hydroxide, and cyanogen azide. Compound <B>4</B> was also formed with 100% nitric acid and 2-(5-aminotetrazol-1-yl)acetic acid which was prepared from sodium 5-aminotetrazolate and 2-chloroacetic acid. New energetic materials comprised of nitroiminotetrazolate salts with nitroiminotetrazolate and carboxylate anions have been characterized spectroscopically as well as with single crystal X-ray diffraction and elemental analyses. In addition, the heats of formation (Δ<I>H</I><SUB>f</SUB>), and detonation pressures (<I>P</I>) and velocities (<I>D</I>) were calculated. All compounds were insensitive (>40 J) for impact with BAM Fallhammer.</P> <P>Graphic Abstract</P><P>High density energetic salts containing nitrogen rich cations and 4-(carboxylatomethyl)-5-nitroiminotetrazol-1-ide have good calculated detonation properties for environmentally friendly explosive applications. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2jm30322a'> </P>

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