A Study on the Audience Subjectivity in Postmodern Condition : The Paranoiac and The Schizophrenic Type

( Eun Hee?park ) 한국주관성연구학회 1996 주관성연구 Vol.- No.1

A Population-Based Genomic Study of Inherited Metabolic Diseases Detected Through Newborn Screening

Park, Kyoung-Jin,Park, Seungman,Lee, Eunhee,Park, Jong-Ho,Park, June-Hee,Park, Hyung-Doo,Lee, Soo-Youn,Kim, Jong-Won The Korean Society for Laboratory Medicine 2016 Annals of Laboratory Medicine Vol.36 No.6

<P><B>Background</B></P><P>A newborn screening (NBS) program has been utilized to detect asymptomatic newborns with inherited metabolic diseases (IMDs). There have been some bottlenecks such as false-positives and imprecision in the current NBS tests. To overcome these issues, we developed a multigene panel for IMD testing and investigated the utility of our integrated screening model in a routine NBS environment. We also evaluated the genetic epidemiologic characteristics of IMDs in a Korean population.</P><P><B>Methods</B></P><P>In total, 269 dried blood spots with positive results from current NBS tests were collected from 120,700 consecutive newborns. We screened 97 genes related to NBS in Korea and detected IMDs, using an integrated screening model based on biochemical tests and next-generation sequencing (NGS) called NewbornSeq. Haplotype analysis was conducted to detect founder effects.</P><P><B>Results</B></P><P>The overall positive rate of IMDs was 20%. We identified 10 additional newborns with preventable IMDs that would not have been detected prior to the implementation of our NGS-based platform NewbornSeq. The incidence of IMDs was approximately 1 in 2,235 births. Haplotype analysis demonstrated founder effects in p.Y138X in <I>DUOXA2</I>, p.R885Q in <I>DUOX2</I>, p.Y439C in <I>PCCB</I>, p.R285Pfs<SUP>*</SUP>2 in <I>SLC25A13</I>, and p.R224Q in <I>GALT</I>.</P><P><B>Conclusions</B></P><P>Through a population-based study in the NBS environment, we highlight the screening and epidemiological implications of NGS. The integrated screening model will effectively contribute to public health by enabling faster and more accurate IMD detection through NBS. This study suggested founder mutations as an explanation for recurrent IMD-causing mutations in the Korean population.</P>

Serum Levels of Persistent Organic Pollutants and Insulin Secretion among Children Age 7–9 Years: A Prospective Cohort Study

Park, Su Hyun,Ha, Eunhee,Hong, Young Sun,Park, Hyesook U.S. Dept. of Health, Education, and Welfare, Publ 2016 Environmental health perspectives Vol.124 No.12

<P><B>Background:</B></P><P>Persistent organic pollutants (POPs) are endocrine disruptors and have been suggested as possible risk factors for diabetes. Few studies have been performed to investigate this association among children.</P><P><B>Objectives:</B></P><P>In this study, we prospectively examined the relationship between the serum concentration of POPs and glucose metabolism in children.</P><P><B>Methods:</B></P><P>Data were collected from the Ewha Birth & Growth Cohort Study, an ongoing birth cohort study initially constructed between 2001 and 2006. In 2010–2012, the POP concentration was measured in serum from a total of 214 children, 7–9 years of age. Using fasting glucose and insulin measurements at both baseline and the second year of follow-up, the homeostatic model assessment of beta-cell function (HOMA-β) and homeostatic model assessment of insulin resistance (HOMA-IR) were calculated. Multiple linear regression analysis and a linear mixed-effects model were used to determine the relationship between POP tertiles and metabolic biomarkers.</P><P><B>Results:</B></P><P>Compared with the lowest tertile of total marker PCBs, participants in the third tertile had decreased HOMA-β values, after adjustment for age, sex, body mass index z-score, mother’s education, ponderal index, and history of breastfeeding (–18.94%; 95% CI: –32.97%, –1.98%). In a linear mixed model, the HOMA-β values were still lower in subjects in the highest compared with the lowest tertile of total PCBs at the 2-year follow-up period (108.3 vs. 135.0, respectively).</P><P><B>Conclusion:</B></P><P>The results of the study suggested that exposure to POPs among children might affect insulin secretory function, which could lead to an increased risk of developing diabetes.</P><P><B>Citation:</B></P><P>Park SH, Ha EH, Hong YS, Park H. 2016. Serum levels of persistent organic pollutants and insulin secretion among children age 7–9 years: a prospective cohort study. Environ Health Perspect 124:1924–1930; http://dx.doi.org/10.1289/EHP147</P>

Changes in proteinuria and the associated risks of ischemic heart disease, acute myocardial infarction, and angina pectoris in Korean population

Sung Keun Park(Sung Keun Park),Ju Young Jung(Ju Young Jung),Min-Ho Kim(Min-Ho Kim),Chang-Mo Oh(Chang-Mo Oh),Eunhee Ha(Eunhee Ha),Eun Hye Yang(Eun Hye Yang),Hyo Choon Lee(Hyo Choon Lee),Soonsu Shin(Soo 한국역학회 2023 Epidemiology and Health Vol.45 No.-

OBJECTIVES: Proteinuria is widely used to predict cardiovascular risk. However, there is insufficient evidence to predict how changes in proteinuria may affect the incidence of cardiovascular disease. METHODS: The study included 265,236 Korean adults who underwent health checkups in 2003-2004 and 2007-2008. They were categorized into 4 groups based on changes in proteinuria (negative: negative → negative; resolved: proteinuria ≥1+ → negative; incident: negative → proteinuria ≥1+; persistent: proteinuria ≥1+ → proteinuria ≥1+). We conducted 6 years of follow-up to identify the risks of developing ischemic heart disease (IHD), acute myocardial infarction (AMI), and angina pectoris according to changes in proteinuria. A multivariate Cox proportional-hazards model was used to calculate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for incident IHD, AMI, and angina pectoris. RESULTS: The IHD risk (expressed as HR [95% CI]) was the highest for persistent proteinuria, followed in descending order by incident and resolved proteinuria, compared with negative proteinuria (negative: reference, resolved: 1.211 [95% CI, 1.104 to 1.329], incident: 1.288 [95% CI, 1.184 to 1.400], and persistent: 1.578 [95% CI, 1.324 to 1.881]). The same pattern was associated with AMI (negative: reference, resolved: 1.401 [95% CI, 1.048 to 1.872], incident: 1.606 [95% CI, 1.268 to 2.035], and persistent: 2.069 [95% CI, 1.281 to 3.342]) and angina pectoris (negative: reference, resolved: 1.184 [95% CI, 1.065 to 1.316], incident: 1.275 [95% CI, 1.160 to 1.401], and persistent: 1.554 [95% CI, 1.272 to 1.899]). CONCLUSIONS: Experiencing proteinuria increased the risks of IHD, AMI, and angina pectoris even after proteinuria resolved.

Correlation of Breast Cancer Incidence with the Number of Motor Vehicles and Consumption of Gasoline in Korea

Park, Boyoung,Shin, Aesun,Jung-Choi, Kyunghee,Ha, Eunhee,Cheong, Hae-Kwan,Kim, Hyun Jeong,Park, Kyung Hwa,Jang, Sungmi,Moon, Byung-In,Ha, Mina Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

While several reproductive and lifestyle-related factors are already well-known as established risk factors for breast cancer, environmental factors have attracted attention only recently. The objective of the current study was to assess the association between the breast cancer incidences in females, the mortality rate and the number of motor vehicles on the one side and the consumption of gasoline which could work as a major source of air pollution at the other side. The breast cancer incidences and the mortality trends were compared with various indices of westernization like dietary patterns or industrialization with 10 years lag of time. Geographical variations with 10, 15 and 20 years lag of time were assessed between the breast cancer incidence in 2010 and the number of motor vehicles as well as the consumption of gasoline. The upward trend of motor vehicle numbers proved to be comparable to those of breast cancer incidence and mortality. However, the consumption of gasoline started to decrease since the mid-1990s. The geographic distribution of motor vehicle numbers and gasoline consumption in 1990 is in a positive correlation with the breast cancer incidence rates in 2010 and the 20-year lag time ($R^2$ 0.379 with the number of motor vehicles and 0.345 with consumption of gasoline). In a linear relationship between the breast cancer incidences in 2010 and the log transformed number of motor vehicles, the log transformed consumption of gasoline in 2000 also showed a positive relationship ($R^2$ 0.367 with the number of motor vehicles and 0.329 with consumption of gasoline). The results of the current study indicate that there may be a positive relation between the number of vehicles, gasoline consumption and the incidence of breast cancer from the aspects of long-term trends and geographical variation.

Molecular Genetic Analysis of nm23-H1 Gene in Korean Colorectal Cancers

Park, Minkoo,Yoon, Wan Hee,Lee, Kong-Joo,Kim, Eunhee 이화여자대학교 생명과학연구소 1995 생명과학연구논문집 Vol.6 No.-

We have performed molecular genetic analysis of the nm23-H1 gene on 17 Korean colorectal cancer patients. The cDNA, intron Ⅰ, and intron Ⅳ of nm23-HⅠ gene were used as probes to examine the loss of heterizygosity(LOH) in Korean colorectal tumor. Southern blot analysis using three proces suggested that functional and/or non-functional nm23-HⅠ homologous gene copies might exist in the human genome. Among the three proves, intron Ⅳ probe seemed to be the most specific one under our hybridization condition. Southern blot analysis with colon cancer cell lines showed 7.6 kb and/or 2.3 kb bands. none of the colon cancer cell lines displayed loss of both bands. Southern blot analysis of Korean colorectal tumors and corresponding normal mucosas with BglⅡ using intron Ⅳ probe demonstrated 3 size bands: 7.6, 4.3, and 2.3 kb. This deserves attention because only 7.6 and 2.3 kb bands appeared in Causasian and Japanese cases. The identity of the 4.3 kb band is not yet understood. Three out of 17 Korean colon cancer patients (17.6%) showed LOH when 7.6 kb and 2.3 kb bands were considered. This frequency is slightly higher than that in Japanese colorectal tumors, where 10.3% of LOH was reported (Okada et al., 1994). However whis frequency is lower than those of two independent studies, in which the LOH of colorectal tumores were 52.3% and 22%, respectively (Cohn et al., 1991; Leone et al., 1991a)

Molecular Genetic Analysis of nm23-H1 Gene in Korean Colorectal Cancers

Park, Minkoo,Yoon, Wan Hee,Lee, Kong-Joo,Kim, Eunhee 梨花女子大學校 藥學硏究所 1995 藥學硏究論文集 Vol.- No.5

We have performed molecular genetic analysis of the nm23-H1 gene on 17 Korean colorectal cancer patients. The cDNA, intron I, and intron Ⅳ of nm23-H1 gene were used as probes to examine the loss of heterozygosity (LOH) in Korean colorectal tumor. Southern blot analysis using three probes suggested that functional and/or non-functional nm23-H1 homologous gene copies might exist in the human genome. Among the three probes, intron Ⅳ probe seemed to be the most specific one under our hybridization condition. Southern blot analysis with colon cancer cell lines showed 7.6 kb and/or 2.3 kb bands. None of the colon cancer cell lines displayed loss of both bands. Southern blot analysis of Korean colorectal tumors and corresponding normal mucosas with BglⅡ using intron Ⅳ probe demonstrated 3 size bands: 7.6, 4.3, and 2.3 kb. This deserves attention because only 7.6 and 23 kb bands appeared in Caucasian and Japanese cases. The identity of the 4.3 kb band is not yet understood. Three out of 17 Korean colon cancer patients (17.6%) showed LOH when 7.6 kb and 2.3kb bands were considered. This frequency is slightly higher than that in Japanese colorectal tumors, where 10.3% of LOH was reported (Okada et, al., 1994). However this frequency is lower than those of two independent studies, in which the LOH of colorectal tumors were 52.3% and 22%, respectively (Cohn et al., 1991; Leone et al., 1991a).

The Lifshitz-van der Waals acid-base theory assisted fabrication of MFI-containing mixed matrix membranes for gas separations

Park, Sunghwan,Jang, Eunhee,An, Heseong,Choi, Wansuk,Kim, Jeong-Hoon,Lee, Jung-Hyun,Choi, Jungkyu,Lee, Jong Suk Elsevier 2018 Microporous and mesoporous materials Vol.264 No.-

<P><B>Abstract</B></P> <P>A zeolite-containing mixed matrix membrane (MMM) is an attractive option to overcome the performance limits of polymeric membranes for large-scale gas separations. The poor interfacial adhesion between zeolites and polymers, however, should be addressed to realize the excellent separation performance of zeolites on large industrial scale. Herein, the interfacial void-free MMMs with incorporation of intact MFI type zeolite particles were successfully prepared by applying the Lifshitz-van der Waals acid-base theory for the selection of the appropriate polymer matrix. Our simple, but systematic approach was based on the adhesion force between MFI particles and a surrounding polymer matrix. The relatively high Lewis basicity of cellulose acetate (CA) leads to highest adhesion force with MFI particles among the tested polymer matrices, suppressing interfacial void formation. In addition, a careful analysis revealed that any residual surfactants on the surface of MFI particles are detrimental to fabricate interfacial void-free MMMs. Single gas (i.e. N<SUB>2</SUB> and NF<SUB>3</SUB>) transport in the CA/MFI MMMs were characterized by changing the concentration of MFI particles up to 30 wt%. N<SUB>2</SUB> permeability of CA/MFI MMMs was improved by as much as 304% compared to that of bare CA membranes with maintaining N<SUB>2</SUB>/NF<SUB>3</SUB> permselectivity. Furthermore, gas transports in CA/MFI MMMs by varying the size of MFI particles from 0.2 through 0.6 up to 1.5 <I>μ</I>m were analyzed by using the Lewis-Nielsen model. Our systematic theory-based guidance can be utilized to offer the appropriate polymer candidates for the zeolite-containing MMMs for high performance gas separations.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A simple acid-base theory was systematically applied for ideal MFI-containing MMMs. </LI> <LI> The high carbonyl mole fractions of CA induced a good adhesion between CA and MFI. </LI> <LI> The effect of structure directing agents on the formation of MMMs was investigated. </LI> <LI> Gas transport behaviors in CA/MFI MMMs were analyzed by varying the size of MFI. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Interhemispheric Modulation of Dual-Mode, Noninvasive Brain Stimulation on Motor Function

Park, Eunhee,Kim, Yun-Hee,Chang, Won Hyuk,Kwon, Tae Gun,Shin, Yong-Il Korean Academy of Rehabilitation Medicine 2014 Annals of Rehabilitation Medicine Vol.38 No.3

<P><B>Objective</B></P><P>To investigate the effects of simultaneous, bihemispheric, dual-mode stimulation using repetitive transcranial magnetic stimulation (rTMS) and transcranial direct current stimulation (tDCS) on motor functions and cortical excitability in healthy individuals.</P><P><B>Methods</B></P><P>Twenty-five healthy, right-handed volunteers (10 men, 15 women; mean age, 25.5 years) were enrolled. All participants received four randomly arranged, dual-mode, simultaneous stimulations under the following conditions: condition 1, high-frequency rTMS over the right primary motor cortex (M1) and sham tDCS over the left M1; condition 2, high-frequency rTMS over the right M1 and anodal tDCS over the left M1; condition 3, high-frequency rTMS over the right M1 and cathodal tDCS over the left M1; and condition 4, sham rTMS and sham tDCS. The cortical excitability of the right M1 and motor functions of the left hand were assessed before and after each simulation.</P><P><B>Results</B></P><P>Motor evoked potential (MEP) amplitudes after stimulation were significantly higher than before stimulation, under the conditions 1 and 2. The MEP amplitude in condition 2 was higher than both conditions 3 and 4, while the MEP amplitude in condition 1 was higher than condition 4. The results of the Purdue Pegboard test and the box and block test showed significant improvement in conditions 1 and 2 after stimulation.</P><P><B>Conclusion</B></P><P>Simultaneous stimulation by anodal tDCS over the left M1 with high-frequency rTMS over the right M1 could produce interhemispheric modulation and homeostatic plasticity, which resulted in modulation of cortical excitability and motor functions.</P>

Combination of ion exchange system and biological reactors for simultaneous removal of ammonia and organics

Park, Wooshin,Jang, Eunhee,Lee, Myun-Joo,Yu, Seungho,Kim, Tak-Hyun Elsevier 2011 Journal of environmental management Vol.92 No.4

<P><B>Abstract</B></P><P>A novel process for a simultaneous removal of ammonia and organics was developed on the basis of ion exchange and biological reactions. From batch experiments, it was found out that NH<SUB>4</SUB><SUP>+</SUP> could be removed effectively by combining cation exchange and biological nitrification showing 0.98 mg N/m<SUP>2</SUP>∙s of a maximum flux. On the other hand, the removal of NO<SUB>3</SUB><SUP>−</SUP> was 3.5 times faster than NH<SUB>4</SUB><SUP>+</SUP> and the maximum flux was calculated to be 3.4 mg N/m<SUP>2</SUP>∙s. The systems for NH<SUB>4</SUB><SUP>+</SUP> and NO<SUB>3</SUB><SUP>−</SUP> removal were combined for establishing the IEBR process. When the process was operated in a continuous mode, approximately 95.8% of NH<SUB>4</SUB><SUP>+</SUP> was removed showing an average flux of 0.22 mg N/m<SUP>2</SUP>·s. The removal efficiency of total nitrogen was calculated as 94.5% whereas that of organics was 99.5%. It was concluded that the IEBR process would be effectively used for a simultaneous removal of NH<SUB>4</SUB><SUP>+</SUP> and organics.</P>