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Gastrointestinal tract cancer in ESRD patients
( Mi Ra You ),( Keo Woon Park ),( Hyun Jin Jung ),( Sang Gon Park ),( Chi Young Park ),( Chun Hae Jung ),( Jun Lee ),( Young Dae Kim ),( Chan Guk Park ),( Man Woo Kim ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1
Background: Previous studies have suggested that the frequency of cancer is higher in patients with dialysis and kidney transplantation than in the general population. The study of cancer in patients treated with dialysis in Korea fewer reported. The aim of this study was to investigate the incidence, types of cancer, time to discovery of cancer and effect of early screening among patients on dialysis in Chosun University Hospital. Method: The study subjects were 25 cancer patients out of 796 end-stage renal disease (ESRD) patients maintained on hemodialysis or peritoneal dialysis at Chosun University Hospital from January 2002 to March 2010. We observed frequency of cancer, dialysis mode, cause of ESRD, time to discovery of cancer, cancer staging and cancer therapy among these patients. Result: Among the study population (796 ESRD patients), malignant disease were diagnosed in 25 patients(3.14%). Mean age at first dialysis was 54.3 yr. Mean age at cancer diagnosis was 59.4yr. Seventeen (68%) of our subjects were male and eight (32%) were female. The mean time from the start of dialysis to the diagnosis of cancer was 49.3(0-168) months. The most common cancer site was gastrointestinal tract (GIT) (32%) followed by urinary tract (20%) and genital tract (16%). During first year, cancer incidence highly compared to other period. Except for stage II, lower stage was longer time to interval cancer diagnosis. Conclusion: In ESRD patients, the incidence of GIT cancer and urinary tract cancer is higher, thus, careful surveillance for malignancies is recommended. Key word: End-Stage Renal Disease (ESRD), Cancer, dialysis.
Park, Si-Hwan,Kim, Hyun Jung,Yim, Soon-Ho,Kim, Ah-Ra,Tyagi, Nisha,Shen, Haihong,Kim, Kyung Keun,Shin, Boo Ahn,Jung, Da-Woon,Williams, Darren R. American Chemical Society and American Society of 2014 Journal of natural products Vol.77 No.11
<P>Quercetin is a plant-derived flavonoid and its cytotoxic properties have been widely reported. However, in nature, quercetin predominantly occurs as various glycosides. Thus far the cytotoxic activity of these glycosides has not been investigated to the same extent as quercetin, especially in animal models. In this study, the cytotoxic properties of quercetin (<B>1</B>), hyperoside (quercetin 3<I>-O-</I>galactoside, <B>2</B>), isoquercitrin (quercetin 3<I>-O-</I>glucoside, <B>3</B>), quercitrin (quercetin 3<I>-O-</I>rhamnoside, <B>4</B>), and spiraeoside (quercetin 4′<I>-O-</I>glucoside, <B>5</B>) were directly compared in vitro using assays of cancer cell viability. To further characterize the influence of glycosylation in vivo, a novel zebrafish-based assay was developed that allows the rapid and experimentally convenient visualization of glycoside cleavage in the digestive tract. This assay was correlated with a novel human tumor xenograft assay in the same animal model. The results showed that <B>3</B> is as effective as <B>1</B> at inhibiting cancer cell proliferation in vivo. Moreover, it was observed that <B>3</B> can be effectively deglycosylated in the digestive tract. Collectively, these results indicate that <B>3</B> is a very promising drug candidate for cancer therapy, because glycosylation confers advantageous pharmacological changes compared with the aglycone, <B>1</B>. Importantly, the development of a novel and convenient fluorescence-based assay for monitoring deglycosylation in living vertebrates provides a valuable platform for determining the metabolic fate of naturally occurring glycosides.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2014/jnprdf.2014.77.issue-11/np500231g/production/images/medium/np-2014-00231g_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np500231g'>ACS Electronic Supporting Info</A></P>
박재경,김병호,김영일,김효종,김경진,장린,이정일,동석호,장영운,성세라 대한소화기학회 2000 대한소화기학회지 Vol.35 No.5
Background/Aims : The cryopreservation of primary hepatocytes could avoid unnecessary isolation of hepatocytes and meet repeated investigational demands. We tried to find out an optimal cryopreservation method of rat hepatocytes. Methods: Primary hepatocytes with more than 90% viability were cryopreserved with the manual or computer-programmable freezing method. We analyzed the effects of the composition (basal medium or fetal bovine serum, FBS) of cryopreservation media, cell concentration, and freezing method on cell viability. Results: Two-step addition of cryopreservation medium (4%→16% DMSO) improved cell viability, compared to its one-step addition (82.7±2.5 vs 73.3±2.1%, p=0.008). In the manual method, the cell viability was about 60% and the culture attachment rate was less than 1%. They were not related with the composition of media used. These results showed that the manual method was not efficacious for cryopreservation. However, about 80% of the cell viability and 50% of the culture attachment e could be obtained with an optimal computer-programmable method (-2℃ slow cooling rate with a shock cooling, 2×106/mL cell concentration, 10-20% FBS, 10% DMSO). Moreover, the culture attachment rate was increased up to 75% when Percoll density purification was applied. Conclusions: Primary hepatocytes can be effectively cryopreserved by an optimal computer-programmable freezing method and Percoll density purification, but not by the manual method.
The Prevalence and Characteristics of Brown Adipose Tissue in an $^{18}F$-FDG PET Study of Koreans
Park, Joon-Yeun,Lim, Jung-Sub,Park, Eun-Young,Cho, A-Ra,Kim, Byeong-Il,Cheon, Gi-Jeong,Choi, Chang-Woon,Lim, Sang-Moo The Korea Society of Nuclear Medicine 2010 핵의학 분자영상 Vol.44 No.3
Purpose The object of this study was to evaluate the prevalence and characteristics of brown adipose tissue (BAT) in Korean subjects using $^{18}F$-fluorodeoxyglucose positron emission tomography ($^{18}F$-FDG PET). Methods Six thousand and five consecutive $^{18}F$-FDG PET/CT scans of 5,115 patients (3,007 females and 2,108 males, mean age 53.5 years) were retrospectively reviewed. We characterized the nature of BAT, such as its location, and we assessed the influence of sex, age, body mass index (BMI), and temperature on BAT. Results The prevalence of BAT in Koreans in a single $^{18}F$-FDG PET/CT scan in average conditions was 1.07%. The BAT detection rate was higher in females than males (1.32% vs 0.73%), and also with younger age (7.94% vs 0.73%), lower BMI (BMI with BAT, 21.1 vs BMI without BAT, 23.15) and cold outdoor temperature (1.65% vs 0.49%). The most frequent location of BAT was the supraclavicular area (left, 0.91%; right, 0.88%) and ventral neck area (left, 0.62%; right, 0.63%). Conclusions The characteristics of BAT in Koreans are not different from those described for Caucasians. However, the low prevalence of BAT in our study might be related to some scan condition like ambient temperature, but further study is needed.
MEMS space Telescope for the observation of Extreme Lightening (MTEL)
Park, Jae-Hyoung,Garipov, Garik,Jeon, Jin-A,Jin, Joo-Young,Jung, Ae-Ra,Kim, Ji-Eun,Kim, Min-Soo,Kim, Yong-Kweon,Klimov, Pavel,Khrenov, Boris,Lee, Chang-Hwan,Lee, Jik,Na, Go-Woon,Nam, Ji-Woo,Nam, Shin- 한국우주과학회 2009 한국우주과학회보 Vol.18 No.1