Sterculic Acid and Its Analogues Are Potent Inhibitors of Toxoplasma gondii

Pan Hao,Intisar Q. M. Alaraj,Juma’a R. Al Dulayymi,Mark S. Baird,Jing Liu,Qun Liu 대한기생충학열대의학회 2016 The Korean Journal of Parasitology Vol.54 No.2

Supercritical fluid extraction effectively removes phthalate plasticizers in spores of Ganoderma lucidum

Pan Li,Zuan-hao Liang,Zhuo Jiang,Ziyou Qiu,Bing Du,Yu-bing Liu,Wen-zhi Li,Li-hao Tan 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.6

Phthalate plasticizers residue in food is a serious threat to public health. Spores of Ganoderma lucidum are easy to be contaminated with phthalates during collection and processing. In this study, supercritical fluid extraction (SFE) was performed to remove phthalates in spores of G. lucidum, and the effects on acid and peroxide values of spores’ oil were also evaluated. The results showed SFE removed 100% of the residual di-iso-butyl phthalate, di-nbutyl phthalate and di-2-ethylhexyl phthalate in the spores of G. lucidum. No significant differences in polysaccharides content and fatty acid composition were observed between SFE and control spores. However, the triterpenoid extracts of SFE spores had a 7.45% increase, significantly higher than that in control spores. Accelerated oxidation tests further implied that SFE could improve the stability of spores’ oil. Our results suggested SFE is a potential approach to remove phthalate from food related products.

A Hybrid Self-Powered System Based on Wind Energy Harvesting for Low-Power Sensors on Canyon Bridges

Hao Cao,Xiaoping Wu,Hao Wu,Yajia Pan,Dabing Luo,Ali Azam,Zutao Zhang 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.10 No.1

Canyon cross wind has great potential to be transformed into electricity to power for low-power sensors of the health monitoring devices in bridge field. In this paper, a hybrid wind energy harvesting system (WEHS), integrating piezoelectric and electromagnetic mechanisms, is proposed to supply power for low-power sensors on canyon bridges. Firstly, the S-rotor embedded with a one-way bearing converts wind energy into rotational mechanical energy. Then, the piezoelectric cantilever beam and coils simultaneously convert mechanical energy into electricity under the excitation of the rotational magnet array. For the piezoelectric transducer, the symmetrical poles arrangement of tip magnet reduces the starting wind speed and resistance torque during energy harvesting. In addition, the relationship between different number of excitation magnets and the output of the piezoelectric transducer is explored. Finally, the output electricity is stored in the capacitors to supply power for low power sensors. The experimental results showed that the symmetrical poles arrangement of tip magnet could effectively reduce the starting resistance torque and improve the output power at low wind speeds. Given a wind speed of 6.5 m/s, the maximum output power of the WEHS can reach 19.24 mW with corresponding electrical energy of 75.714 mJ in one sweep period (6 s). The field test results demonstrated that the WEHS could effectively charge for the capacitors and power for a hundred LEDs. Furthermore, the mechanical durability and stability of the WEHS are verified by introducing a self-powered low power sensor system.

Failure Modes of Large-scale Landslides Induced by 2009 Typhoon Morakot in Southern Taiwan

( Keng-hao Kang ),( Hao-hsun Lin ),( Yii-wen Pan ),( Jyh-jong Liao ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2

After the catastrophic landslide at the Shiaolin village during the 2009 Typhoon Morakot, many large-scale landslide areas were delineated using LiDAR DEM. Among those, 356 large-scale landslides caused by the Typhoon Morakot are in southern Taiwan. In addition to the delineation task, the assessment of landslide activity is also essential for risk management. This study aims to classify the failure modes of large scale landslides in order to provide information for further assessment. For remote sensing interpretation, this study adopted google satellite images, multi-period aerial photos, 5x5m/1x1m DEM, and geologic maps. Arc GIS was used to calculate the geomorphic index of the landslides before and after 2009 Typhoon Morakot. We used a variety of parameters including drainage system, shape of bare areas, and characteristics of topography to identify the failure modes of landslides. As a result, this study classify the large-scale landslides induced by the Typhoon Morakot into six categories: colluvium slide, dip slope slide, weathered bedrock slide, rock avalanche, shallow debris slide, and complex type. Among those cases, ten sites are possibly related with gravitational slope deformation.

Research on Characteristic Parameter of Ta-Zro2 Fiber Blackbody Cavity Temperature Sensor

Hao Xiao-jian,Sang Tao,Pan Bao-wu,Zhou Han-chang 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.2

By sputtering and plasma spraying technology, a sapphire optical fiber blackbody cavity temperature sensor of tantalum (melting point is 2997℃) - zirconium oxide (melting point is 2715℃) thin film was developed. Static calibration system for the sensor to measure target temperature 1721℃ is also designed by using three oxygen (produced by water electrolysis) flame guns. When its impact resistant capacity is more than 50MPa, the corresponding temperature is 2802℃. A high power and high frequency modulation CO2 laser pulse is used as exciting source to heat it to 1500℃, and the dynamic calibration device is designed independently, thus this sensor in experimental results show a time response on the order of μs. Signal collection and transmission through fiber optic cable are proposed, which can meet the need of transient high temperature measurement in harsh environment.

Recurrent neural networks for nonparametric modeling of ship maneuvering motion

Hao Lizhu,Han Yang,Shi Chao,Pan Ziying 대한조선학회 2022 International Journal of Naval Architecture and Oc Vol.14 No.1

A Recurrent Neural Network (RNN) model is presented in this paper to predict the ship maneuvering motion. Inputs to the model are the orders of rudder angle and its variation as well as the propeller speed (ship speed) and also the recursive outputs velocities of surge, sway and yaw. The past values for the velocities are retained in the inputs to indicate the influence of historical state of motion on the maneuvering prediction. The KRISO Container Ship (KCS) is taken as the study object. The data obtained from a manoeuvring mathematical model and free-running model test are respectively used to train the neural network. Tactical circles and zigzags are simulated by the RNN, the prediction for maneuvers not involved in the training set shows that the RNN in this paper has good generalization performance. The concept of uncertainty is proposed to be considered in the further work through the analysis.

Toxoplasma gondii Induces Apoptosis via Endoplasmic Reticulum Stress-Derived Mitochondrial Pathway in Human Small Intestinal Epithelial Cell-Line

Hao Wang,Chunchao Li,Wei Ye,Zhaobin Pan,Jinhui Sun,Mingzhu Deng,Weiqiang Zhan,Jiaqi Chu 대한기생충학열대의학회 2021 The Korean Journal of Parasitology Vol.59 No.6

Effects of clopidogrel and clarithromycin on the disposition of sibutramine and its active metabolites M1 and M2 in relation to CYP2B6*6 polymorphism

Pan, Wei,Bae, Soo-Kyung,Shim, Eon-Jeong,Park, Sung-Eun,Lee, Sang-Seop,Park, Soo-Jin,Yeo, Chang-Woo,Zhou, Hong-Hao,Shon, Ji-Hong,Shin, Jae-Gook Informa Healthcare 2013 Xenobiotica Vol.43 No.2

<OL><LI><P>Plasma concentrations of sibutramine and its two active metabolites after single oral dose of sibutramine were determined in Korean healthy male subjects with different CYP2B6 genotypes (CYP2B6*1/*1, *1/*6 and *6/*6), either alone or after four-day pretreatment with clopidogrel or clarithromycin.</P></LI><LI><P>The pretreatment with clopidogrel and clarithromycin raised the mean area under the concentration-time curve (AUC) of sibutramine by 163% and 255%, respectively.</P></LI><LI><P>Co-administration of clarithromycin, combined with <I>CYP2B6*6/*6</I> genotype, led to highest concentration of sibutramine.</P></LI><LI><P>The molar sum AUC (M1 + M2) was raised by 35% in the clopidogrel phase but not significantly affected by clarithromycin or CYP2B6 genotype.</P></LI><LI><P>The <I>CYP2B6*6/*6</I> subjects in the clopidogrel phase showed the highest molar AUC (M1 + M2) among three genotype groups throughout the three phases.</P></LI><LI><P>The exposure of sibutramine and its metabolites seemed to be associated with the CYP2B6 genotype.</P></LI><LI><P>The treatment of clopidogrel significantly altered the disposition of active metabolites as well as sibutramine, but clarithromycin only affects the disposition of sibutramine.</P></LI><LI><P>These results suggest that the perturbation of CYP2B6 activity may contribute to the inter-individual variation of sibutramine drug responses although the clinical relevance is remained to be established.</P></LI></OL>

Novel Intensity-Based Fiber Optic Vibration Sensor Using Mass-Spring Structure

Hao Yi(호일),Hyeon-Ho Kim(김현호),Sang-Jin Choi(최상진),Jae-Kyung Pan(반재경) 대한전자공학회 2014 전자공학회논문지 Vol.51 No.6

본 논문에서는 질량-스프링 구조를 이용한 새로운 광세기 기반 광섬유 진동센서를 제안하고 시뮬레이션과 부분 실험을 통하여 그 실현 가능성을 제시한다. 제안한 광세기 기반 광섬유 진동센서는 네 개의 구불구불하게 휘어지는 스프링과 질량체 안의 사각형 개구면(aperture)으로 구성된 질량-스프링 구조를 가진다. 광시준기(optical collimator)는 질량체 안의 사각형 개구면의 변위에 의해서 변조되는 광을 넓히는 데 이용된다. 제안한 광섬유 진동센서를 광학적인 면과 기계적인 면에서 해석하고 설계한다. 기계적인 부분의 설계는 이론적인 해석, 수학적인 모델링 및 3 차원 유한요소법 시뮬레이션을 이용한다. 기계적인 진동이 가해질 때 개구면의 상대적인 변위관계를 3차원 유한요소법 시뮬레이션을 이용하여 구하고, 개구면의 상대적인 변위에 따른 출력값을 실험을 통하여 측정한다. 이를 이용하여 진동에 따른 출력 특성을 파악한 결과 센서 민감도 15.731 μW/G, 감지 영역 ±}6.087 G를 얻었다. 그리고 입력광원의 파워가 10 dB까지 변하더라도 참조광을 이용하여 0.75%의 상대오차를 보이는 매우 안정된 출력광 파워를 얻었다. 제안한 광섬유 진동센서는 간단한 구조, 저비용 및 다지점 측정 가능의 특징을 가지면서, MEMS (Micro-Electro-Mechanical System) 기술을 이용하여 소형으로 간편하게 제작할 수 있는 잠재력을 가진다. In this paper, a novel intensity-based fiber optic vibration sensor using a mass-spring structure, which consists of four serpentine flexure springs and a rectangular aperture within a proof mass, is proposed and its feasibility test is given by the simulation and experiment. An optical collimator is used to broaden the beam which is modulated by the displacement of the rectangular aperture within the proof mass. The proposed fiber optic vibration sensor has been analyzed and designed in terms of the optical and mechanical parts. A mechanical structure has been designed using theoretical analysis, mathematical modeling, and 3D FEM (Finite Element Method) simulation. The relative aperture displacement according to the base vibration is given using FEM simulation, while the output beam power according to the relative displacement is measured by experiment. The simulated sensor sensitivity of 15.731 μW/G and detection range of ±6.087 G are given. By using reference signal, the output signal with 0.75% relative error shows a good stability. The proposed vibration sensor structure has the advantages of a simple structure, low cost, and multi-point sensing characteristic. It also has the potential to be made by MEMS (Micro-Electro-Mechanical System) technology.

LCL APF based on fractional-order fast repetitive control strategy

Pan, Guobing,Gong, Fei,Jin, Libing,Wu, Hao,Chen, Sihan The Korean Institute of Power Electronics 2021 JOURNAL OF POWER ELECTRONICS Vol.21 No.10

The LCL type active power filter (APF) with a traditional repetitive controller has drawbacks in terms of poor dynamic performance, large steady-state error, and difficult digital implementation. A fast repetitive control (RC) algorithm was proposed in this paper in an effort to improve the APF dynamic performance without worsening its stability. To eliminate the non-integer delay of the traditional RC, a fractional-order RC algorithm based on the Lagrangian Interpolation was developed. The proposed fast fractional-order RC (FFORC) strategy only needs 1/6 delay time when compared to the traditional RC. In addition, it can track the error signal quickly and obtain a higher steady-state accuracy. Furthermore, the double current loops control method with grid side current and inverter side current feedback is proposed to achieve active damping of the resonance peak of the LCL filter, which ensures that the APF system is stable. Simulation and experimental results are presented to verify the performance of the dynamic response and steady-state accuracy of the proposed FFORC strategy.