Effect of Cynodon dactylon on rotenone induced Parkinson's disease

Sharma, Neha,Bafna, Pallavi 경희한의학연구센터 2012 Oriental Pharmacy and Experimental Medicine Vol.12 No.3

In the present study, the aqueous extract of Cynodon dactylon (AECD) Pers. (Graminae) was evaluated for anti-parkinson's activity in rats.The anti-parkinson's effect of AECD was studied against rotenone (2 mg/kg, s.c.) - induced parkinsons in rats. In this study, chronic administration of rotenone in rats (28 days) produced motor dysfunctions like catalepsy and muscle rigidity along with a reduction in locomotor activity. Rotenone administration was also found to generate oxidative stress in the brain as evident from an increase in the level of TBARS and decrease in the levels of SOD and GSH. Pretreatment with AECD resulted in a significant (p<0.001) decrease in catalepsy and muscle rigidity along with a significant (p<0.001) increase in locomotion as compared to the rotenone-treated control group. AECD treated rats also showed a reduction in the TBARS level and an increase in the GSH, SOD and CAT levels; thus reducing the oxidative stress in the brain of animals. The study thus proved that Cynodon dactylon treatment significantly attenuated the motor defects and also protected the brain from oxidative stress, both induced by rotenone. These results strongly indicate the possible therapeutic potential of Cynodon dactylon as an antioxidant in Parkinson's disease and other movement disorders.

An Insight of Nanomaterials in Tissue Engineering from Fabrication to Applications

Sharma Ritika,Kumar Sanjeev,Bhawna,Gupta Akanksha,Dheer Neelu,Jain Pallavi,Singh Prashant,Kumar Vinod 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.5

Tissue engineering is a research domain that deals with the growth of various kinds of tissues with the help of synthetic composites. With the culmination of nanotechnology and bioengineering, tissue engineering has emerged as an exciting domain. Recent literature describes its various applications in biomedical and biological sciences, such as facilitating the growth of tissue and organs, gene delivery, biosensor-based detection, etc. It deals with the development of biomimetics to repair, restore, maintain and amplify or strengthen several biological functions at the level of tissue and organs. Herein, the synthesis of nanocomposites based on polymers, along with their classification as conductive hydrogels and bioscaffolds, is comprehensively discussed. Furthermore, their implementation in numerous tissue engineering and regenerative medicine applications is also described. The limitations of tissue engineering are also discussed here. The present review highlights and summarizes the latest progress in the tissue engineering domain directed at functionalized nanomaterials.

An Ontology Based Text Analytics on Social Media

Pankajdeep Kaur,Pallavi Sharma,Nikhil Vohra 보안공학연구지원센터 2015 International Journal of Database Theory and Appli Vol.8 No.5

The amount of digital information that is created and used is progressively rising along with the growth of sophisticated hardware and software. In addition, real-world data come in a diversity of forms and can be tremendously bulky. This has augmented the need for powerful algorithms that can deduce and dig out appealing facts and useful information from these data. Text Mining (TM), which is a very complex process; has been successfully used for this purpose. Text mining alternately referred to as text data mining, more or less equivalent to text analytics, can be defined as the process of extracting high-quality information from text. Text mining involves the process of structuring the input data, deriving patterns within the structured data and lastly interpretation and revelation of the output. This paper provides outline on text analytics and social media analytics. At the end, this paper presents our proposed work based on ontology framework to cope up with excessive social media textual data.

An Ontology Based E-Learning System

Pankajdeep Kaur,Pallavi Sharma,Nikhil Vohra 보안공학연구지원센터 2015 International Journal of Grid and Distributed Comp Vol.8 No.5

Based upon several new technologies that have been developed such as semantic web, SPARQL language and ontology engineering, this paper proposes platform architecture for e-learning. It is an e-learning management system with metadata. This system consists of ontology for the e-learning process, such as teaching methods, learning styles, learning activities and course syllabus. It helps students, administrative staff and teachers to set up and maintain the course data and go through the learning content. This system architecture will be capable of gaining user adaptability, performance scalability and concept reusability. It has ability to act in an intelligent manner by evaluating the academics initially and then provide personalized suggestions to the academics indicating their weaknesses and strengths.

Nutrient recycling of source-separated human faeces using biochar immobilized indigenous psychrotrophic bacteria for sustaining the agroecosystems of north-western Himalaya

Borker Shruti Sinai,Thakur Aman,Pandey Krishna Kanta,Sharma Pallavi,Manyapu Vivek,Khatri Abhishek,Kumar Rakshak 한국응용생명화학회 2024 Applied Biological Chemistry (Appl Biol Chem) Vol.67 No.-

The Himalayan composting toilets (CTs) offer a sustainable solution for converting human faeces (HF) into com post, supplementing the low-fertile land of the region. However, CTs face challenges such as delayed composting processes (6–8 months), increased heavy metal content, and foul odour. Therefore, the current study evaluated biochar-amended psychrotrophic bacteria for HF degradation under low-temperature conditions (10 ± 2 °C). Out of 153 psychrotrophic bacteria isolated from HF compost, 17 bacterial strains were selected based on highest and two or more hydrolytic activities. Furthermore, considering the isolation source, bacterial strains were exam ined for haemolytic activity, biofilm formation, cytotoxicity and seed germination assay. In total, 14 potential strains belonging to Pseudomonas, Microbacterium, Arthrobacter, Streptomyces, Glutamicibacter, Rhodococcus, Serratia, Exig uobacterium, and Jeotgalicoccus genera were considered safe for both human handling and plants. The composting process was conducted in modified plastic drums at 10 ± 2 °C for 90 days through two treatments: Treatment 1 (T1) involving HF, non-immobilized biochar and cocopeat, and Treatment 2 (T2) involving HF, consortium-immobilized biochar and cocopeat. The consortium-immobilized biochar (T2) degraded HF within 90 days with hemicellulose and cellulose degradation ratios of 73.9% and 62.4%, respectively (p ≤ 0.05). The compost maturation indices like C/N ratio (16.5 ± 1.85), total nitrogen (2.66 ± 0.07), total phosphate (0.4 ± 0.005), total potassium (1.8 ± 0.05) also improved in T2 treatment (p ≤ 0.05). Additionally, T2 was more effective in achieving safe levels of faecal coliforms (< 1000 MPN g−1) and reducing heavy metal content compared to T1. 16S rRNA amplicon-based analysis demonstrated an enhancement of bacterial community diversity in T2, with the presence of Rhodococcus, Pseudomonas, Arthro bacter, and Streptomyces at the end of the composting period promoting HF degradation. Furthermore, T2-fertilized soil showed a germination index (121 ± 0.4, p ≤ 0.05) and stimulated root, shoot and yield by 110%, 45.2%, and 288%, respectively, in pea (Pisum sativum var. AS-10) compared to T1 (49.6%, 19%, and 5.8%, respectively) (p ≤ 0.05). In con clusion, the developed biochar-based formulation proved effective in degrading HF at low temperatures, mitigating foul odours, reducing heavy metals, and enhancing the agronomic value of the final compost. This study presents a promising approach for the sustainable management of HF that can supplement the non-nutritive soil of high altitude regions.