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Neuromyelitis optica and multiple sclerosis: Seeing differences through optical coherence tomography
Bennett, JL,de Seze, J,Lana-Peixoto, M,Palace, J,Waldman, A,Schippling, S,Tenembaum, S,Banwell, B,Greenberg, B,Levy, M,Fujihara, K,Chan, KH,Kim, HJ,Asgari, N,Sato, DK,Saiz, A,Wuerfel, J,Zimmermann, H SAGE Publications 2015 Multiple sclerosis journal: clinical and laborator Vol.21 No.6
<P>Neuromyelitis optica (NMO) is an inflammatory autoimmune disease of the central nervous system that preferentially targets the optic nerves and spinal cord. The clinical presentation may suggest multiple sclerosis (MS), but a highly specific serum autoantibody against the astrocytic water channel aquaporin-4 present in up to 80% of NMO patients enables distinction from MS. Optic neuritis may occur in either condition resulting in neuro-anatomical retinal changes. Optical coherence tomography (OCT) has become a useful tool for analyzing retinal damage both in MS and NMO. Numerous studies showed that optic neuritis in NMO typically results in more severe retinal nerve fiber layer (RNFL) and ganglion cell layer thinning and more frequent development of microcystic macular edema than in MS. Furthermore, while patients’ RNFL thinning also occurs in the absence of optic neuritis in MS, subclinical damage seems to be rare in NMO. Thus, OCT might be useful in differentiating NMO from MS and serve as an outcome parameter in clinical studies.</P>
Influence of pregnancy on neuromyelitis optica spectrum disorder
Kim, W.,Kim, S.- H.,Nakashima, I.,Takai, Y.,Fujihara, K.,Leite, M. I.,Kitley, J.,Palace, J.,Santos, E.,Coutinho, E.,Silva, A. M.,Kim, B.-J.,Kim, B.-J.,Ahn, S.- W.,Kim, H. J. Ovid Technologies (Wolters Kluwer) - American Acad 2012 Neurology Vol.78 No.16
<P>To investigate the influence of pregnancy on patients with neuromyelitis optica spectrum disorder (NMOSD).</P>
Daiana Guillen,Pilar Barranco,Arantxa Palacín,Santiago Quirce 대한천식알레르기학회 2014 Allergy, Asthma & Immunology Research Vol.6 No.5
We report the case of a snack processor who developed occupational rhinoconjunctivitis due to maize brand exposure during the extrusion process,and who experienced abdominal pain upon drinking beer. The allergens implicated and the cross-reactivity between non-specific lipid transfer proteins(LTPs) from different cereals and peach were investigated. Skin prick tests and specific IgE to cereal flours, pulmonary functions tests and specificconjunctival and inhalation challenges to maize extract were performed. In vitro studies included IgE immunoblotting and ELISA inhibition assays. Skin prick tests with maize flour, maize brand and wheat flour extracts were positive, whereas serum specific IgE was positive only to maize flour. Specificinhalation challenge (SIC) to maize flour did not elicit an asthmatic reaction; however, conjunctival challenge test with the same extract was positive. Patient’s serum recognized IgE-binding bands in the maize and beer extracts corresponding to LTPs. In the ELISA inhibition assays, a significantdegree of allergenic cross-reactivity was found between maize and beer LTPs, whereas no cross-reactivity was observed between maize LTP andwheat and peach LTPs.