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Postprandial Lipemia, Genetics and CHD Risk
Ordovas, Jose M. The Korean Nutrition Society 2003 Nutritional Sciences Vol.6 No.4
New biochemical and genetic markers will be required to be more successful in the prevention of coronary heart disease. Postprandial lipid metabolism has received considerable attention since it was shown that postprandial triglyceride-rich lipoproteins are independently involved in the development of atherosclerosis. Multiple genes and environmental factors work in concert to alter these lipid. In this paper, postprandial lipemia, genetic variation and cardiovascular risk will be reviewed.
Raquel Hauschild,Marlon Dalmoro,Maria Amália Machado,Stefania Ordovas de Almeida 한국마케팅과학회 2020 Journal of Global Fashion Marketing Vol.11 No.3
Fashion inspired by local culture references is our starting point for understanding how fashion, as a contemporary and dynamic dimension, can preserve the capacity of representing and maintaining local traditions. Through an interpretive approach, we look at the relationship between traditional clothing preservation and the creation of a contemporary fashion associated with the gaucho traditionalist culture in southern Brazil. The study counts on 22 indepth interviews with consumers and producers of the traditional and contemporary gaucho fashion movement, as well as document analysis and netnographic data exploration on gaucho traditions. Results indicate that even facing the resistance from conservative groups that aim to keep clothing stable over time, fashion producers and consumers associated the contemporary gaucho clothes as a modern mechanism for tradition preservation. It allows the adjustment of tradition representation in line with changes in social roles, especially gender patterns. Findings reveal that contemporary gaucho fashion challenges the rigid conception of tradition, once it represents a democratic instrument able to supply a sense of belonging adjusted to contemporary time. Finally, we theorize about the ability of symbolic representations of a particular culture to be transferred to emerging fashion elements over time, without losing the bond with the local tradition.
Kwak, J.H.,Paik, J.K.,Kim, O.Y.,Jang, Y.,Lee, S.H.,Ordovas, J.M.,Lee, J.H. Elsevier Scientific Publ. Co 2011 Atherosclerosis Vol.214 No.1
Objective: We investigated the association of polymorphisms in FADS genes with polyunsaturated fatty acids (PUFAs) in serum phospholipids, lipid peroxides, and coronary artery disease (CAD) in Koreans. Methods: In this case-control study, CAD patients (n=756, 40-79 years) and healthy controls (n=890) were genotyped for rs174537 near FADS1 (FEN1 rs174537G>T), FADS2 (rs174575, rs2727270), and FADS3 (rs1000778). We calculated the odds ratios (ORs) for CAD risk and measured serum PUFA composition and lipid peroxide. Results: Among four SNPs, only rs174537G>T differed in allele frequencies between controls and CAD patients after adjustment for age, BMI, cigarette smoking, alcohol consumption, hypertension, diabetes mellitus, and hyperlipidemia (P=0.017). The minor T allele was associated with a lower risk of CAD [OR 0.75 (95%CI 0.61-0.92), P=0.006] after adjustment. rs174537T carriers had a significantly higher proportion of linoleic acid (LA, 18:2ω6), lower arachidonic acid (AA, 20:4ω6), and lower ratios of AA/dihomo-γ-linolenic acid (DGLA, 20:3ω6) and AA/LA than G/G subjects in both control and CAD groups. In the control group, 174537T carriers had significantly lower levels of total- and LDL-cholesterol, malondialdehyde, and ox-LDL. In CAD patients, rs174537T carriers showed a larger LDL particle size than G/G subjects. The proportion of AA in serum phospholipids positively correlated with LDL-cholesterol, ox-LDL, and malondialdehyde in controls and with 8-epi-prostaglandin F<SUB>2α</SUB> in both control and CAD groups. Conclusion: The rs174537T is associated with a lower proportion of AA in serum phospholipids and reduced CAD risk, in association with reduced total- and LDL-cholesterol and lipid peroxides.