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RISS 인기검색어
- 검색키워드
- 저자 : Omar M.E. Abdel-Salam (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Citric Acid Effects on Brain and Liver Oxidative Stress in Lipopolysaccharide-Treated Mice
Omar M.E. Abdel-Salam,Eman R. Youness,Nadia A. Mohammed,Safaa M. Youssef Morsy,Enayat A. Omara,Amany A. Sleem 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.5
Citric acid is a weak organic acid found in the greatest amounts in citrus fruits. This study examined the effect of citric acid on endotoxin-induced oxidative stress of the brain and liver. Mice were challenged with a single intraperitoneal dose of lipopolysaccharide (LPS; 200 lg/kg). Citric acid was given orally at 1, 2, or 4 g/kg at time of endotoxin injection and mice were euthanized 4 h later. LPS induced oxidative stress in the brain and liver tissue, resulting in marked increase in lipid peroxidation (malondialdehyde [MDA]) and nitrite, while significantly decreasing reduced glutathione, glutathione peroxidase (GPx), and paraoxonase 1 (PON1) activity. Tumor necrosis factor-alpha (TNF-a) showed a pronounced increase in brain tissue after endotoxin injection. The administration of citric acid (1–2 g/kg) attenuated LPS-induced elevations in brain MDA, nitrite, TNF-a, GPx, and PON1 activity. In the liver, nitrite was decreased by 1 g/kg citric acid. GPx activity was increased, while PON1 activity was decreased by citric acid. The LPS-induced liver injury, DNA fragmentation, serum transaminase elevations, caspase-3, and inducible nitric oxide synthase expression were attenuated by 1–2 g/kg citric acid. DNA fragmentation, however, increased after 4 g/kg citric acid. Thus in this model of systemic inflammation, citric acid (1–2 g/kg) decreased brain lipid peroxidation and inflammation, liver damage, and DNA fragmentation.
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Antihypertensive and Cardioprotective Effects of Pumpkin Seed Oil
Aliaa E.M.K. El-Mosallamy,Amany A. Sleem,Omar M.E. Abdel-Salam,Nermeen Shaffie,Sanaa A. Kenawy 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.2
Pumpkin seed oil is a natural product commonly used in folk medicine for treatment of prostatic hypertrophy. In the present study, the effects of treatment with pumpkin seed oil on hypertension induced by the nitric oxide synthase inhibitor Nx-nitro-l-arginine methyl ester hydrochloride (l-NAME) (50 mg /kg/day) in rats were studied and compared with those of the calcium channel blocker amlodipine. Pumpkin seed oil (40 or 100 mg/kg), amlodipine (0.9 mg/kg), or vehicle (control) was given once daily orally for 6 weeks. Arterial blood pressure (BP), heart rate, electrocardiogram (ECG) changes,levels of serum nitric oxide (NO) (the concentrations of nitrite/nitrate), plasma malondialdehyde (MDA), blood glutathione,and erythrocytic superoxide dismutase activity were measured. Histopathological examination of heart and aorta was conducted as well. l-NAME administration resulted in a significant increase in BP starting from the second week. Pumpkin seed oil or amlodipine treatment significantly reduced the elevation in BP by l-NAME and normalized the l-NAME-induced ECG changes—namely, prolongation of the RR interval, increased P wave duration, and ST elevation. Both treatments significantly decreased the elevated levels of MDA and reversed the decreased levels of NO metabolites to near normal values compared with the l-NAME-treated group. Amlodipine also significantly increased blood glutathione content compared with normal (but not l-NAME-treated) rats. Pumpkin seed oil as well as amlodipine treatment protected against pathological alterations in heart and aorta induced by l-NAME. In conclusion, this study has shown that pumpkin seed oil exhibits an antihypertensive and cardioprotective effects through a mechanism that may involve generation of NO.
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