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- 저자 : Olga Tzakou (검색결과 2 건)
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Chemical Composition and Biological Activities of Calamintha officinalis Moench Essential Oil
Maria Teresa Monforte,Olga Tzakou,Antonia Nostro,Vincenzo Zimbalatti,Enza Maria Galati 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.3
Calamintha officinalis Moench essential oil is used in cooking as an aromatic herb and also to improve the flavor and fragrance of several pharmaceutical products. The essential oil, obtained by hydrodistillation (5mL=kg), was analyzed by gas chromatography–mass spectrometry and gas chromatography–flame ionization detection. Sixty-four components were identified,constituting 99.7% of the total oil. The major component was found to be carvone (38.7%), followed by neo-dihydrocarveol (9.9%), dihydrocarveol acetate (7.6%), dihydrocarveol (6.9%), 1,8 cineole (6.4%), cis-carvyl acetate (6.1%), and pulegone (4.1%). The essential oil showed antifungal and antimicrobial activity against Gram-positive bacteria. In addition, it presented a very low toxicity both in vivo (50%lethal dose>100mg=kg) and in vitro in the Artemia salina test (50%lethal concentration>500 uL=mL). C. officinalis essential oil, in rodents, produces the typical effects in behavior of a nonselective central nervous system-depressant drug; it potentiates the hypnotic effects of sodium pentobarbital, decreasing the induction time and enhancing the sleeping time. Moreover, it produces a decrease in body temperature and a protection against pentylenetetrazole-induced convulsions.
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Antioxidant Activity of Nepeta nuda L. ssp. nuda Essential Oil Rich in Nepetalactones from Greece
George Gkinis,Biljana Bozin,Neda Mimica-Dukic,Olga Tzakou 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.5
Essential oils from air-dried leaves and verticillasters of Nepeta nuda ssp. nuda from Greece were analyzed by means of gas chromatography-flame ionization detection and gas chromatography-mass spectrometry. The dominant constituent in the verticillaster oils was 4aα,7α,7aβ-nepetalactone (75.7%). The main metabolites of the leaf oil were 1,8-cineole (16.7%), 4aα,7α,7aβ-nepetalactone (24.7%), and caryophyllene oxide (16.3%). The oils were examined for their antioxidant activity. Neutralization of stable 2,2-diphenyl-1-picrylhydrazyl radical ranged from 10.83% (2.50μg/mL) to 58.64% (50.00μg/mL) for verticillaster oil and from 6.25% (2.50μg/mL) to 57.79% (50.00μg/mL) for leaf oil. The essential oil from verticillasters had significant effects on lipid peroxidation (in the range of 41.18–59.23%), compared to tert-butylated hydroxytoluene (37.04%). In contrast, the essential oil from leaves exhibited pro-oxidant activity at the highest concentration applied.
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