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A Study on Disability and Impairment of Dental Disorders in Korea
Ahn, Yong-Woo,Jang, Seok-Min,Jeong, Sung-Hee,Jeon, Hye-Mi,Kim, Kyung-Hee,Ok, Soo-Min Korean Academy of Orofacial Pain and Oral Medicine 2018 Journal of Oral Medicine and Pain Vol.43 No.3
The definition and application of disability are becoming more important as society becomes more complex. The precise criteria for the assessment and classification of disabilities are primarily focused on certain medical conditions with a lack of guidelines for dental conditions. This study provides an evaluation and comparison of the current tables available for the assessment of disabilities in the dental field with the aim of identifying areas to be improved.
Ahn, Bo-Eun,Bae, Hee-Won,Lee, Hae-Ri,Woo, Sun-Je,Park, Ok-Kyu,Jeon, Jun Ho,Park, Jungchan,Rhie, Gi-eun Elsevier 2019 Biochemical and biophysical research communication Vol.509 No.2
<P><B>Abstract</B></P> <P>Since <I>Bacillus anthracis</I> is a high-risk pathogen and a potential tool for bioterrorism, numerous therapeutic methods including passive immunization have been actively developed. Using a human monoclonal antibody phage display library, we screened new therapeutic antibodies for anthrax infection against protective antigen (PA) of <I>B. anthracis</I>. Among 5 selected clones of antibodies based on enzyme-linked immunosorbent assay (ELISA) results, 7B1 showed neutralizing activity to anthrax lethal toxin (LT) by inhibiting binding of the domain 4 of PA (PD4) to its cellular receptors. Through light chain shuffling process, we improved the productivity of 7B1 up to 25 folds. The light chain shuffled 7B1 antibody showed protective activity against LT both <I>in vitro</I> and <I>in vivo</I>. Furthermore, the antibody also conferred protection of mice from 3 × LD<SUB>50</SUB> challenges of fully virulent anthrax spores. Our result expands the possibility of developing a new therapeutic antibody for anthrax cure.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We screened a novel therapeutic antibody for anthrax using phage display library. </LI> <LI> The selected antibody recognizes domain 4 of protective antigen of anthrax toxin. </LI> <LI> The selected antibody showed anthrax toxin-neutralizing efficacy in mouse model. </LI> </UL> </P>
Self-checking Type, Repetitive, Education Efficacy for Temporomandibular Disorder Patients
Ok, Soo-Min,Kim, Kyung-Hee,Heo, Jun-Young,Ahn, Yong-Woo,Jeong, Sung-Hee Korean Academy of Orofacial Pain and Oral Medicine 2015 Journal of Oral Medicine and Pain Vol.40 No.2
Purpose: The purpose of this research was twofold: to compare the short-term efficacy of once-off education versus repetitive education (RE) of patients suffering from temporomandibular disorders (TMDs) and to determine whether there was any correlation amongst patient demographics, recommendation adherence degree and pain levels. Methods: A total of 848 patients with TMDs were enrolled. The control group consisted of patients who received a standard conservative treatment (STD) over at least 6 visits with education provided only during the first visit. The experimental group consisted of patients who received STD but had also been given RE (STD+RE). The RE was delivered through a standardized self-assessment questionnaire (SAQ) that was completed by the patient during each visit. Pain, which included maximum comfortable opening (MCO) of the mouth and limitation of mouth opening (LOM), was compared between the two groups. Behavior pattern and reported pain level changes in the group who used the SAQ were also analyzed. Results: The LOM was significantly improved in all of the experimental group patients (especially in females under 30 years of age, p<0.05). The MCO was significantly higher in females (p=0.029). All of the patients displayed improvements in their habits following RE, which resulted in a strong correlation with pain reduction. Adhering to the recommendations regarding questions 14 and 15 of the SAQ appeared to have the greatest effect on pain reduction. Conclusions: These results clearly demonstrate that RE is more effective than once-off education for TMD patients who are female or under 30 years of age.
Ahn, Chi-Yeong,Hwang, Wonchan,Lee, Hyunjoon,Kim, Sungjun,Park, Ji Eun,Kim, Ok-Hee,Her, Min,Cho, Yong-Hun,Sung, Yung-Eun Elsevier 2018 International journal of hydrogen energy Vol.43 No.21
<P><B>Abstract</B></P> <P>An ideal oxygen reduction catalyst for use in fuel cells should exhibit both long-term durability and high activity. In this study, to increase the durability of highly loaded platinum- and platinum-nickel alloy catalysts possessing different types of carbon supports, a nitrogen-doped carbon shell was introduced on the catalyst surface through dopamine coating. As the catalyst surfaces were altered following shell formation, the ionomer contents of the catalyst inks were adjusted to optimise the three-phase boundary formation. Single cell tests were then conducted on these inks by applying them in a membrane electrolyte assembly. Furthermore, to confirm the durability of the catalysts under accelerated conditions, the operation was continued for 200 h at 70 °C and at a relative humidity of 100%. Transmission electron microscopy and electrochemical analysis were conducted before and after the durability tests, and the observed phenomena were discussed for catalysts bearing different types of carbon supports.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Nitrogen-doped carbon shell by dopamine coating is introduced to highly-loaded Pt and PtNi alloy catalysts. </LI> <LI> Pt and PtNi catalysts are supported on carbon black and heat-treated carbon, respectively. </LI> <LI> Performance and durability were improved by applying a Pt-alloy catalyst in combination with a N-doped carbon shell. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Human adipose tissue-derived mesenchymal stem cells inhibit melanoma growth in vitro and in vivo.
Ahn, Jin-Ok,Coh, Ye-Rin,Lee, Hee-Woo,Shin, Il-Seob,Kang, Sung-Keun,Youn, Hwa-Young Potamitis Press 2015 Anticancer research Vol.35 No.1
<P>The effects of adipose tissue-derived mesenchymal stem cells (AT-MSCs) on the growth of human malignancies, including melanoma, are controversial and the underlying mechanisms are not yet-well understood. The aim of the present study was to investigate the in vitro and in vivo anti-tumor effects of human AT-MSCs on human melanoma.</P>
Assessment of vitamin $B_6$ status in Korean patients with newly diagnosed type 2 diabetes
Ahn, Hee-Jung,Min, Kyung-Wan,Cho, Youn-Ok The Korean Nutrition Society 2011 Nutrition Research and Practice Vol. No.
The purpose of this study was to assess vitamin $B_6$ intake and status in Korean patients with newly diagnosed type 2 diabetes. Sixty-four patients with newly diagnosed type 2 diabetes and 8-11% glycated hemoglobin (A1C), along with 28 age-matched non-diabetic subjects, participated. Dietary vitamin $B_6$ intake was estimated by the 24 hour recall method and plasma pyridoxal 5'-phosphate (PLP) was measured. There was a significant difference in daily total calorie intake between the diabetic and non-diabetic groups ($1,917{\pm}376$ vs $2,093{\pm}311\;kcal$). There were no differences in intake of total vitamin $B_6$ ($2.51{\pm}0.91$ vs $2.53{\pm}0.81\;mg/d$) or vitamin $B_6$/1,000 kcal ($1.31{\pm}0.42$ vs $1.20{\pm}0.32\;mg$) between the diabetic and non-diabetic groups, and I intakes of total vitamin $B_6$ were above the Korean RDA in both groups ($180.0{\pm}57.9$ vs $179.0{\pm}65.4$). There was a higher percentage of diabetic subjects whose plasma PLP concentration was < 30 nmol/L compared to non-diabetic group. Plasma PLP levels tended to be lower in the diabetic subjects than in the non-diabetic subjects, although the difference was not statistically significant due to a large standard deviation ($80.0{\pm}61.2\;nmol/L$ vs $68.2{\pm}38.5\;nmol/L$). Nevertheless, plasma PLP levels should be monitored in pre-diabetic patients with diabetic risk factors as well as in newly diagnosed diabetic patients for long-term management of diabetes, even though this factor is not a major risk factor that contributes to the development of degenerative complications in certain patients.