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RISS 인기검색어
- 검색키워드
- 저자 : Nurullah Koç,ak,Bilge Eraydın (검색결과 2 건)
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Serum Inflammatory Biomarkers in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy
Nurullah Koç,ak,Bilge Eraydın,Mustafa Turunç,,Volkan Yeter,İ,nci Gü,ngö,r 대한안과학회 2020 Korean Journal of Ophthalmology Vol.34 No.6
Purpose: To evaluate the neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyteratio (PLR), and systemic immune-inflammation index (SII) in patients with non-arteritic anterior ischemic optic neuropathy(NAION). Methods: Fifty-six patients with NAION and 60 age-sex matched healthy controls were included in the study. Demographiccharacteristics and laboratory findings of the patients and the controls were obtained from the electronic medical records. NLR, PLR, MLR, and SII were calculated and compared between the groups. Cutoff values were also determined. Results: Neutrophil, monocyte and platelet counts were higher in the NAION group than in the control group, but the differencewas not statistically significant (p > 0.05). The mean NLR and SII were higher in the NAION group than in the controlgroup (p = 0.004 and p = 0.011, respectively). In the receiver operating characteristic curve analysis, the areas under thecurve for NLR were 0.67, and NLR >1.79 predicted NAION with a sensitivity of 71% and specificity of 59%. The areas under thecurve for SII was 0.66, and SII of >417 predicted NAION with a sensitivity of 71% and specificity of 49%. There was no significantdifference in PLR and MLR between the groups (p = 0.105 and p = 0.347, respectively). Conclusions: The current study demonstrated that NAION patients had increased NLR and SII levels compared with controlsubjects. Elevated NLR and SII might serve as readily available inflammatory predictors in NAION patients.
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Blood Count-derived Immunoinflammatory Markers in Thyroidassociated Ophthalmopathy
Volkan Yeter,Nurullah Koç,ak,Mehmet Tayfun Arslan,Elif Kiliç, Kan 대한안과학회 2021 Korean Journal of Ophthalmology Vol.35 No.3
Purpose: To investigate the diagnostic and prognostic significance of the blood-count derived systemic immunoinflammatory parameters in patients with thyroid-associated ophthalmopathy (TAO). Methods: In this retrospective case-control study, the blood-count parameters and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio, and systemic immune-inflammatory index (SII), thyroid peroxidase antibody, and anti-thyroglobulin antibody were evaluated in 46 patients with TAO and 46 matched controls. The associations of the immunoinflammatory parameters with clinical outcomes were analyzed among TAO patients. Results: Significant differences were found in NLR, PLR, SII, and lymphocyte count between the controls and the TAO group (p < 0.05 for all). In logistic regression analysis, these inflammatory parameters did not have any prognostic effect on the clinical outcomes of the TAO (p > 0.05 for all). The patients, who needed systemic treatment due to any ocular involvement of TAO during the follow-up period, had significantly lower platelet count (p = 0.001) and PLR (p = 0.02) at the time of initial diagnosis when compared to the no treatment-needed group of the TAO patients. The initial platelet count was significantly associated with the subsequent steroid need due to TAO during the follow-up period (β = -0.02, p = 0.03). Conclusions: NLR, PLR, and SII may serve as potential inflammatory markers in the identification of the TAO, although they have no evident prognostic significance in TAO. However, the relatively lower platelet count at initial diagnosis may be associated with the need for systemic therapy during the follow-up in patients with TAO.
KCI
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