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      • KCI등재

        Zingiber officinale Roscoe (Ginger) as a Complementary Option for Clinical Treatment of Endometriosis: An Experimental Study in Rats

        José Meneses de Morais Filho,João Nogueira Neto,Lyvia Maria Rodrigues de Sousa Gomes,Izabelle Smith Fraza˜o Ramos,Salie Santos Rodrigues Oliveira,George Castro F. Melo,Lucilene Amorim Silva,Ed Carlos 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.4

        Endometriosis was induced (autotransplant) in Wistar rats. After 21 days, the rats were randomly divided into two groups (16 female rats each). Control group was forced-fed 0.9% sodium chloride solution, and the ginger group was forced-fed 0.5 mg/100 g of Zingiber officinale Roscoe fresh extract, both by gavage, for 14 days, in addition to their normal diet. After that, an anesthetic dose (ketamine/xylazine) was administered until euthanasia. Peritoneal lavage fluid was collected to evaluate tumor necrosis factor (TNF)-α and interleukin (IL)-6, and autotransplant was measured and excised to evaluate histology. The final mean volumes were larger in the control group (120.92 mm3 ± 78.91) than in the ginger group (40.50 mm3 ± 19.57) (P = .01). The endometriosis foci increased in the control group from 45.10 mm3 ± 29.96 at 21 days postimplantation to 120.92 mm3 ± 78.91 on the day of euthanasia (P = .02). In the ginger group, a slight increase was observed from 38.43 mm3 ± 19.96 to 40.50 mm3 ± 19.57, without statistical difference (P = .83). In addition, a greater increase in growth of the endometriosis foci was found when compared with the control (75.81 mm3 ± 58.95) and ginger groups (2.07 mm3 ± 18.87) (P = .004). No difference was found in TNF-α (P = .51) and in IL-6 (P = .12). The degree of lesion atrophy was higher in the ginger group (1 ± 0.92) than in the control group (2.25 ± 1.16) (P = .03). The ginger extract reduced and atrophied autotransplanted endometriosis foci, but did not reduce IL-6 and TNF-α in the peritoneal lavage fluid.

      • KCI등재

        Evaluation of Women with Myofascial Abdominal Syndrome Based on Traditional Chinese Medicine

        Andréia Mitidieri,Maria Beatriz Gurian,Ana Paula Silva,Kalil Tawasha,Omero Poli-Neto,Antônio Nogueira,Francisco Reis,Júlio Rosa-e-Silva 대한약침학회 2015 Journal of pharmacopuncture Vol.18 No.4

        Objectives: This study used semiology based on traditionalChinese medicine (TCM) to investigate vital energy(Qi) behavior in women with abdominal myofascialpain syndrome (AMPS). Methods: Fifty women diagnosed with chronic pelvicpain (CPP) secondary to AMPS were evaluated by usinga questionnaire based on the theories of “yin-yang,”“zang-fu”, and “five elements”. We assessed the followingaspects of the illness: symptomatology; specific locationof myofascial trigger points (MTrPs); onset, cause, durationand frequency of symptoms; and patient and familyhistory. The patients tongues, lips, skin colors, and tonesof speech were examined. Patients were questioned onvarious aspects related to breathing, sweating, sleepquality, emotions, and preferences related to color, food,flavors, and weather or seasons. Thirst, gastrointestinaldysfunction, excreta (feces and urine), menstrual cycle,the five senses, and characteristic pain symptoms relatedto headache, musculoskeletal pain, abdomen, andchest were also investigated. Results: Patients were between 22 and 56 years old,and most were married (78%), possessed a elementaryschool (66%), and had one or two children (76%). Themean body mass index and body fat were 26.86 kg/cm2(range: 17.7 — 39.0) and 32.4% (range: 10.7 — 45.7), respectively. A large majority of women (96%) exhibitedalterations in the kidney meridian, and 98% hadan altered gallbladder meridian. We observed majorchanges in the kidney and the gallbladder Qi meridiansin 76% and 62% of patients, respectively. Five of thetwelve meridians analyzed exhibited Qi patterns similarto pelvic innervation Qi and meridians, indicatingthat the paths of some of these meridians were directlyrelated to innervation of the pelvic floor and abdominalregion. Conclusion: The women in this study showed changesin the behavior of the energy meridians, and the pathsof some of the meridians were directly related to innervationof the pelvic floor and abdominal region.

      • KCI등재후보

        Analysis of Functional Electrical Stimulation Parameters by Muscular Contraction Time and Knee Joint Angular Variation

        Eddy Krueger,Eduardo Borba Neves,Percy Nohama,Eduardo Mendonça Scheeren,Guilherme Nunes Nogueira-Neto,Vera Lúcia da Silveira Nantes Button 대한의용생체공학회 2013 Biomedical Engineering Letters (BMEL) Vol.3 No.1

        Purpose In the present study, five FES profiles were compared in order to find the best combination of activeperiod and burst frequency that might artificially sustain muscle contraction for the longest time with the lowest knee joint variation. Methods Spinal cord injured volunteers (N=10) participated in this study. The frequency of each FES profile was 1 kHz with variable pulse active period (100 μs or 200 μs) and pulse inactive period (900 μs or 800 μs). The setup burst frequencies had either 50 Hz (3 ms active time and 17 ms rest time) or 70 Hz (3 ms active time and 11 ms rest time). Results The best results were obtained to FES profiles P2(burst frequency of 70 Hz and pulse active period of 100 μs),P3 (burst frequency of 50 Hz and pulse active period of 200 μs) and P4 (burst frequency of 70 Hz and pulse active period of 200 μs). Conclusions In order to maintain the SCIV´s knee angle with minimal variation, the best results occurred with the application of P2, P3 and P4 FES profiles.

      • SCOPUSKCI등재

        Evaluation of Women with Myofascial Abdominal Syndrome Based on Traditional Chinese Medicine

        Mitidieri, Andreia,Gurian, Maria Beatriz,Silva, Ana Paula,Tawasha, Kalil,Poli-Neto, Omero,Nogueira, Antonio,Reis, Francisco,Rosa-e-Silva, Julio KOREAN PHARMACOPUNCTURE INSTITUTE 2015 Journal of pharmacopuncture Vol.18 No.4

        Objectives: This study used semiology based on traditional Chinese medicine (TCM) to investigate vital energy (Qi) behavior in women with abdominal myofascial pain syndrome (AMPS). Methods: Fifty women diagnosed with chronic pelvic pain (CPP) secondary to AMPS were evaluated by using a questionnaire based on the theories of "yin-yang," "zang-fu", and "five elements". We assessed the following aspects of the illness: symptomatology; specific location of myofascial trigger points (MTrPs); onset, cause, duration and frequency of symptoms; and patient and family history. The patients tongues, lips, skin colors, and tones of speech were examined. Patients were questioned on various aspects related to breathing, sweating, sleep quality, emotions, and preferences related to color, food, flavors, and weather or seasons. Thirst, gastrointestinal dysfunction, excreta (feces and urine), menstrual cycle, the five senses, and characteristic pain symptoms related to headache, musculoskeletal pain, abdomen, and chest were also investigated. Results: Patients were between 22 and 56 years old, and most were married (78%), possessed a elementary school (66%), and had one or two children (76%). The mean body mass index and body fat were 26.86 kg/cm2 (range: 17.7 - 39.0) and 32.4% (range: 10.7 - 45.7), respectively. A large majority of women (96%) exhibited alterations in the kidney meridian, and 98% had an altered gallbladder meridian. We observed major changes in the kidney and the gallbladder Qi meridians in 76% and 62% of patients, respectively. Five of the twelve meridians analyzed exhibited Qi patterns similar to pelvic innervation Qi and meridians, indicating that the paths of some of these meridians were directly related to innervation of the pelvic floor and abdominal region. Conclusion: The women in this study showed changes in the behavior of the energy meridians, and the paths of some of the meridians were directly related to innervation of the pelvic floor and abdominal region.

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