Evaluating the clinical and radiographic outcomes of mini-implant versus conventional implant-supported overdentures: A three-year randomized control prospective study

Anusar Gupta(Anusar Gupta ),Niraj Mishra(Niraj Mishra ),Pooran Chand(Pooran Chand ),Saumyendra Vikram Singh(Saumyendra Vikram Singh ),Raghuwar Dayal Singh(Raghuwar Dayal Singh ),Bhaskar Agarwal(Bhaska 대한치과이식임플란트학회 2022 The Korean Academy of Implant Dentistry Vol.41 No.3

Purpose: This in vivo study compared the clinical and radiographic outcomes of the mini-implant-supported overdenture and conventional implant-supported overdenture. The objectives of the study were to evaluate the pocket depth, crestal bone loss, and implant stability using a periotest and to measure patient satisfaction based on the oral health impact profile EDENT questionnaire in conventional and mini-implants supported overdentures. Materials and Methods: One hundred and seventy-four subjects above 40 years of age were recruited and randomized into two groups on a 1:1 basis: Group 1- mini-implant supported overdentures (2.5 mm diameter×11 mm length) and Group 2-conventional implant- supported overdentures (3.3 mm diameter×11 mm length). Crestal bone loss was measured from the baseline to 12 months and from 12 to 36 months. The pocket depth and implant stability using a Perio test device were measured at 12 months and 36 months. Finally, the patient satisfaction based on the oral health impact profile EDENT questionnaire in conventional and mini-implants supported overdentures was recorded. Results: There was no significant difference (P>0.05) in the pocket depth and crestal bone loss between the groups at 12 months and 36 months. Similarly, there was no significant difference in the perio-test values between the groups at 12 and 36 months. No significant (P>0.05) differences in physical pain, psychological discomfort, and disability were noted. Conclusions: Both conventional and mini-implant-supported overdentures have similar outcomes with respect to the pocket depth, crestal bone loss, implant stability, and overall quality of life of the patient.

Identification of PI3K-AKT signaling as the dominant altered pathway in intestinal type ampullary cancers through whole-exome sequencing

Niraj Kumari,Rajneesh K. Singh,Shravan K. Mishra,Narendra Krishnani,Samir Mohindra,Raghvendra L. 대한병리학회 2021 Journal of Pathology and Translational Medicine Vol.55 No.3

Background: The genetic landscape of intestinal (INT) and pancreatobiliary (PB) type ampullary cancer (AC) has been evolving with distinct as well as overlapping molecular profiles. Methods: We performed whole-exome sequencing in 37 cases of AC to identify the targetable molecular profiles of INT and PB tumors. Paired tumor-normal sequencing was performed on the HiSeq 2500 Illumina platform. Results: There were 22 INT, 13 PB, and two cases of mixed differentiation of AC that exhibited a total of 1,263 somatic variants in 112 genes (2–257 variants/case) with 183 somatic deleterious variants. INT showed variations in 78 genes (1–31/case), while PB showed variations in 51 genes (1–29/case). Targetable mutations involving one or more major pathways were found in 86.5% of all ACs. Mutations in APC, CTNNB1, SMAD4, KMT2, EPHA, ERBB, and Notch genes were more frequent in INT tumors, while chromatin remodeling complex mutations were frequent in PB tumors. In the major signaling pathways, the phosphoinositide 3-kinase (PI3)/AKT and RAS/mitogen-activated protein kinase (MAPK) pathways were significantly mutated in 70% of cases (82% INT, 46% PB, p = .023), with PI3/AKT mutation being more frequent in INT and RAS/MAPK in PB tumors. Tumor mutation burden was low in both differentiation types, with 1.6/Mb in INT and 0.8/Mb in PB types (p = .217). Conclusions: The exome data suggest that INT types are genetically more unstable than PB and involve mutations in tumor suppressors, oncogenes, transcription factors, and chromatin remodeling genes. The spectra of the genetic profiles of INT and PB types suggested primary targeting of PI3/AKT in INT and RAS/RAF and PI3/AKT pathways in PB carcinomas.

Smart grid and nuclear power plant security by integrating cryptographic hardware chip

Kumar, Niraj,Mishra, Vishnu Mohan,Kumar, Adesh Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.10

Present electric grids are advanced to integrate smart grids, distributed resources, high-speed sensing and control, and other advanced metering technologies. Cybersecurity is one of the challenges of the smart grid and nuclear plant digital system. It affects the advanced metering infrastructure (AMI), for grid data communication and controls the information in real-time. The research article is emphasized solving the nuclear and smart grid hardware security issues with the integration of field programmable gate array (FPGA), and implementing the latest Time Authenticated Cryptographic Identity Transmission (TACIT) cryptographic algorithm in the chip. The cryptographic-based encryption and decryption approach can be used for a smart grid distribution system embedding with FPGA hardware. The chip design is carried in Xilinx ISE 14.7 and synthesized on Virtex-5 FPGA hardware. The state of the art of work is that the algorithm is implemented on FPGA hardware that provides the scalable design with different key sizes, and its integration enhances the grid hardware security and switching. It has been reported by similar state-of-the-art approaches, that the algorithm was limited in software, not implemented in a hardware chip. The main finding of the research work is that the design predicts the utilization of hardware parameters such as slices, LUTs, flip-flops, memory, input/output blocks, and timing information for Virtex-5 FPGA synthesis before the chip fabrication. The information is extracted for 8-bit to 128-bit key and grid data with initial parameters. TACIT security chip supports 400 MHz frequency for 128-bit key. The research work is an effort to provide the solution for the industries working towards embedded hardware security for the smart grid, power plants, and nuclear applications.

Assessment of swallowing and masticatory performance in obturator wearers: a clinical study

Vero, Nungotso,Mishra, Niraj,Singh, Balendra Pratap,Singh, Kamleshwar,Jurel, Sunit Kumar,Kumar, Vijay The Korean Academy of Prosthodonitics 2015 The Journal of Advanced Prosthodontics Vol.7 No.1

PURPOSE. To assess function by identifying changes in swallowing and masticatory performance in maxillary obturator prosthesis wearers. MATERIALS AND METHODS. Sixty subjects were recruited for the study, of which 20 were obturator wearers, 20 were completely dentulous and 20 had removable partial/complete dentures with similar Eichner's Index. Swallowing ability was evaluated with and without obturator using the "Water Drinking Test"; Masticatory performance was evaluated with the Sieve test; and maximum occlusal force was recorded with the help of a digital bite sensor. The data was analyzed using the Statistical Package for Social Science version 15.0 with a confidence level at 95%. RESULTS. Profile, behavior of drinking and time taken to drink were significantly improved (P<.001) in subjects after wearing obturator. Masticatory performance was not significantly different (P=.252) in obturator wearer when compared with dentulous or removable partial/complete denture wearer, but significantly (P<.001) high inter group difference in maximum occlusal force existed. Correlation between masticatory performance and maximum occlusal force was not significant (P=.124). CONCLUSION. Swallowing ability was significantly improved after wearing obturator but masticatory performance was not significantly different from those having similar occlusal support zone in their dentition.

Assessment of swallowing and masticatory performance in obturator wearers: a clinical study

Kamleshwar Singh,Sunit Kumar Jurel,Vijay Kumar,Balendra Pratap Singh,Niraj Mishra,Nungotso Vero 대한치과보철학회 2015 The Journal of Advanced Prosthodontics Vol.7 No.1

PURPOSE To assess function by identifying changes in swallowing and masticatory performance in maxillary obturator prosthesis wearers. MATERIALS AND METHODS Sixty subjects were recruited for the study, of which 20 were obturator wearers, 20 were completely dentulous and 20 had removable partial/complete dentures with similar Eichner's Index. Swallowing ability was evaluated with and without obturator using the "Water Drinking Test"; Masticatory performance was evaluated with the Sieve test; and maximum occlusal force was recorded with the help of a digital bite sensor. The data was analyzed using the Statistical Package for Social Science version 15.0 with a confidence level at 95%. RESULTS Profile, behavior of drinking and time taken to drink were significantly improved (P<.001) in subjects after wearing obturator. Masticatory performance was not significantly different (P=.252) in obturator wearer when compared with dentulous or removable partial/complete denture wearer, but significantly (P<.001) high inter group difference in maximum occlusal force existed. Correlation between masticatory performance and maximum occlusal force was not significant (P=.124). CONCLUSION Swallowing ability was significantly improved after wearing obturator but masticatory performance was not significantly different from those having similar occlusal support zone in their dentition.