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Direct Iliac Vein Stenting in Phlegmasia Cerulea Dolens Caused by May-Thurner Syndrome
Nikolaos Galanakis,Nikolaos Kontopodis,Elias Kehagias,Nikolaos Daskalakis,Konstantinos Tsetis,Christos V. Ioannou,Dimitrios Tsetis 대한혈관외과학회 2021 Vascular Specialist International Vol.37 No.4
Phlegmasia cerulea dolens (PCD) is an uncommon but potentially limb-threatening complication of acute deep vein thrombosis. A 56-year-old male presented with PCD. Color Doppler ultrasonography revealed extensive thrombosis of the left superficial and common femoral and external and common iliac veins. After an unsuccessful iliofemoral thrombectomy, contrast-enhanced computed tomography revealed iliofemoral deep vein thrombosis due to May–Thurner syndrome (MTS). After the deployment of an inferior vena cava filter, the thrombotic occlusion was traversed with a guidewire and direct stenting was performed to achieve immediate recanalization. The patient was discharged two days after the procedure, demonstrating significant clinical improvement. MTS is a rare cause of PCD. Direct iliac vein stenting may be a safe and effective alternative treatment for rapid recanalization if percutaneous mechanical thrombectomy devices are unavailable.
Nikolaos Kontopodis,Dimosthenis Igoumenakis,George Mastorakis,Ioannis Logothetis,Nikolaos Daskalakis,Christos V. Ioannou 대한혈관외과학회 2020 Vascular Specialist International Vol.36 No.4
Head and neck cancers represent an aggressive form of neoplastic diseases thatwarrant surgical resection, in order to achieve optimal outcomes. Moreover, theinvolvement of the carotid artery is associated with a dismal prognosis and radicaltumor resection becomes challenging. The current case report presents a patientwith locally metastatic neck carcinoma attached to the right carotid bifurcation,involving both the external and internal carotid arteries up to the distal segmentof the internal carotid artery (ICA) at the level of the C1 vertebra. The patient underwenten bloc tumor and vessel resection. The carotid artery was reconstructedusing an interposition graft from the common carotid artery to the ICA by meansof an autologous saphenous vein graft. A vertical mandibular osteotomy wasperformed, in order to expose the distal ICA. The postoperative recovery was uneventful. The patient was under follow-up for six months, without any signs ofrecurrence.
Surgical Reconstruction of Traumatic Pseudoaneurysm of Palmar Arch Caused by Blunt Trauma
Nikolaos Papatheodorou,Konstantinos Dimitriadis,Damianos Doukas,Christos Argyriou,George S. Georgiadis 대한혈관외과학회 2022 Vascular Specialist International Vol.38 No.4
Although rare, pseudoaneurysms (PAs) of the palmar arch are mostly considered benign. However, they can cause severe complications if left untreated or misdiagnosed. There are a few data on traumatic PAs of the palmar arch, particularly those most commonly caused by penetrating hand injuries. However, PAs caused by blunt trauma are more insidious in onset, presenting as a painful pulsatile mass in the palmar area of the hand, and require prompt diagnosis and management to avoid catastrophic sequelae. Our case is the first study to describe a patient with traumatic PA of the palmar arch caused by blunt trauma that was treated with surgical reconstruction and venous bypass interposition.
Nikolaos S. Heliopoulos,Georgios N. Kouzilos,Arsenios I. Giarmenitis,Sergios K. Papageorgiou,Kostas Stamatakis,Fotios Κ. Katsaros 한국섬유공학회 2020 Fibers and polymers Vol.21 No.6
Viscose fabrics were modified with alginate and doped with copper ions, to investigate the effect of copper dopingon their antibacterial and UV blocking properties. The modified fabrics were characterized using FTIR, UV spectroscopy,SEM and chromatometric analysis and their copper uptake properties were investigated. The antibacterial effect of thetreatments was evaluated before and after repeated washings (up to 50 cycles). The resulting composite materials showedexcellent antibacterial properties with up to 100 % reduction of bacteria, even from very low copper content, while alginate/copper treatment increased the UV radiation protection index by 261 %, offering a composite fabric with improvedperformance.
Viral Agents Involved in Wheezing and Asthma in Children
( Nikolaos G. Papadopoulos ),( Kalliopi M. Kouloufakou Gratsia ),( Ioannis Christodoulou ) 대한천식알레르기학회 2008 천식 및 알레르기 Vol.28 No.1
The role of respiratory viral infections in the development of childhood asthma remains under intense investigation. There is a plethora of viral agents (rhinoviruses [RV], enteroviruses, respiratory syncytial virus [RSV], metapneumovirus [MPV], adenoviruses, influenza and parainfluenza [PIV] viruses, bocavirus [hBoV], coronaviruses etc) which are associated with asthma exacerbation. Viral infections are also closely linked to infantile wheezing. Severe wheezing infections, such as bronchiolitis, in early infancy may predispose to chronic childhood asthma. The current review focuses on the latest epidemiological reports of asthma exacerbation and wheezing and tries to delineate the associations with viral agents detected during the course of the disease. According to these studies, RV infection is likely the major trigger, initially affecting asthma in school-age children while RSV is associated with severe bronchiolitis. Both agents may contribute to later asthma. Newly discovered agents such as MPV and hBoV have also been suggested as viruses with a propensity to induce wheeze and asthma exacerbations, but more studies are required to evaluate their importance. The prevention or early treatment of respiratory viral infections in children may be an important strategy to improve quality of life for patients who suffered from asthma exacerbations. (Korean J Asthma Allergy Clin Immunol 2008;28:1-9)
Nikolaos Tsafantakis,Efrosini S. Katsanou,Katerina Kyriakopoulou,Eirini-Christina Psarou,Iliana Raptaki,Alexios L. Skaltsounis,Marc Audebert,Kyriaki A. Machera,Nikolas Fokialakis 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.12
Opuntia ficus indica has been an important dietary source and a traditionally used medicinal plant. Given the promising health-promoting properties of this plant, a comparative toxicological assessment and antioxidant bioevaluation of extracts from different parts of the plant were carried out in relation to their chemical profile. Toxicity was examined at multiple endpoints using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide (MTT), Comet and the γH2AX In-Cell Western Assay, while hyphenated ultra-high-performance liquid chromatography-high-resolution mass spectrometry (UHPLC-HRMS) analysis was carried out to identify main constituents. None of the extracts showed any cytotoxic and genotoxic effect on cell lines used, apart from the flower extract in HepG2 cells at the highest concentration tested (2.5 mg/mL). Both fruit flesh and seed extracts demonstrated a prominent protective effect against H2O2-induced genotoxicity in almost all concentrations tested, while extracts originated from flowers and cladodes were effective only at the low non-cytotoxic (0.312 and 0.625 mg/mL) and high (1.25 and 2.5 mg/mL) concentrations, respectively. In total, 2 phenolic acids, 12 flavonoids, along with 3 feruloyl derivatives and the plant pigment indicaxanthin, were tentatively identified by UHPLC-HRMS analysis. Phenolic acids (compounds 1 and 2) were mainly distributed in cladodes (64.6%), while flavonoids (3–14) in the flowers (81.8%). Overall, the highest amount of total flavonoids (22.76 ± 0.015 mg of quercetin equivalent [QE]/g) and total phenolics (62.80 ± 0.009 mg gallic acid equivalents [GAE]/g) was found in the flower extract. Flavonoid glycosides have not been detected in the seeds and the flesh, while the fruit seed extract contained mainly feruloyl derivatives. Our data provide convincing evidences for the lack of cytotoxic and genotoxic effects of O. ficus indica aqueous extracts and, in parallel, support the potential for further exploitation of this plant in the food supplement or functional food sector.
Nikolaos Blontzos,Christos Iavazzo,George Vorgias,Nikolaos Kalinoglou 대한산부인과학회 2019 Obstetrics & Gynecology Science Vol.62 No.4
The development of leiomyomas on the grounds of an aplastic/hypoplastic uterus in patients with Mayer-Rokitansky-Küster-Hauser syndrome (MRKHS) has been rarely described. We report the first case of development of multipleleiomyomas in a patient with MRKHS complicated with pulmonary valve stenosis, and we present a narrative reviewof the existing literature. A 44-year-old patient with MRKHS attended our clinic because of pelvic pain, whichwas attributed to a pelvic mass found on ultrasound. Magnetic resonance imaging revealed a multinodular mass,indicating either ovarian pathology or the presence of leiomyomas. Exploratory laparotomy was performed, andmultiple solid masses on the grounds of two rudimentary uterine buds were observed. Histological analysis revealedmultiple leiomyomas arising from parametrial or paratubal tissue. We searched medical databases for articles relevantto leiomyomas and MRKHS. We present a review of the current literature and summarize the clinical manifestation,diagnosis, management, and histopathological findings of all the cases described. We underline that it is importantfor gynecologists to be aware of this rare clinical entity, and symptomatic leiomyomas cannot be excluded in patientswith MRKHS.