두개강내 배아종의 방사선 치료

노영주(Young Ju Nho),장혜숙(Hyesook Chang),최은경(Eun Kyung Choi),김종훈(Jong Hoon Kim) 대한방사선종양학회 1997 Radiation Oncology Journal Vol.15 No.3

Purpose : Intracranial germinoma is the most radiocurable tumor of the primary intracranial neoplasm. But, the optimum radiation dose and target volume remain controversial. In this retrospective study, we analysed the spreading pattern at presentation and the pattern of the failure and survival of intracranial germinoma. Materials and Methods : From 1989 to 1996, 23 patients were treated for intracranial germinoma at Department of Radiation Oncology. Twenty-one patients were treated at their initial presentation and 2 patients were treated for recurrent disease. Six patients had multiple tumor masses on MRI and 7 patients had ventricular seeding on MRI. The examination of cerebrospinal fluid cytology was done in 15 patients and 3 out of 15 patients had positive cerebrospinal cytology. In tumor marker study of α-FP and β-hCG, 6 patients had mildly elevated β-hCG in serum or cerebrospinal fluid. Twenty- one patients were treated with whole craniospinal axis irradiation and 2 patients were given whole ventricular radiation therapy. The total dose was ranged between 4500cGy and 5600cGy to primary tumor site (median 5580 cGy). Dose to the entire ventricular system ranged from 1980cGy to 3960 cGy (median 2700cGy) and dose to the spinal axis ranged from 2160cGy to 3900cGy (median 2700cGy). Results : Of 23 patients, 21 patients are alive without evidence of disease for median 4 years follow -up. One patient who had markedly elevated α-FP and β-hCG suffered from persistent disease after radiation therapy and received 2 cycles of chemotherapy. She died 9 months after chemotherapy. One patient who developed ventricular seeding after gamma- knife was treated with whole craniospinal irradiation, he died after 1 year due to probably brain necrosis. The hematologic toxicity of 3 or 4 grade were seen in 7 patients, and patient's endocrinologic dysfunction was not deteriorated after radiation therapy. One patient had been treated with growth hormone replacement due to short stature. Conclusions : This retrospective study has confirmed the excellent result of radiation therapy in intracranial germinoma. The complication rate during or after radiation therapy is considered within acceptable range. It is necessary to further investigate the optimal dose and treatment volume of radiation therapy. The role of chemotherapy in the treatment of intracranial germinoma should be further investigated. 목 적 : 두개내 배아종은 방사선 치료로 완치율이 높은 종양이나 현재까지 적절한 방사선 조사량이나 조사 범위에 대한 원칙은 확립되지 않은 상태이다. 본 저자는 본원에서 방사선 치료를 시행한 환자들의 치료 성적과 재발 양상을 알고자 후향적 분석을 하였다. 대상 및 방법 : 1989년에서 1996년까지 방사선 치료를 시행한 23명의 환자를 대상으로 하였다. 이 중 21명은 처음 진단시 본과에서 방사선 치료를 하였고 나머지 2명은 재발 뒤 본과에서 방사선 치료를 받았다. 자기공명영상상 6명에서 다발성종괴가 관찰되었고 7명에서 뇌실 내 전이소견이 보였다. 뇌척추액검사를 시행한 15명중 3명에서 종양 세포가 관찰되었다. 종양지표검사상 6명에서 혈장이나 뇌척추액의 베타 융모성선자극 호르몬의 수치가 다소 상승되어 있었다. 21명은 전뇌척수조사를 받았고 2명은 전뇌실조사를 받았다. 결 과 : 23명 중 21명은 현재 중앙 추적 기간 4 년 시점에서 무병 상태로 관찰되고 있다. 치료 중 백혈구 감소가 3 또는 4단계인 환자는 7명이었고 방사선조사후 내분비 상태가 악화된 환자는 없었다. 전뇌척수조사를 받은 환자중 1명이 저신장으로 성장 호르몬 치료를 받고 있다. 결 론 : 본원에서 치료한 두개내 배아종은 기존의 보고와 마찬가지로 높은 관해율을 보이고 있다. 치료 중이나 치료 후의 부작용의 정도와 빈도는 현시점에서 허용 범위에 있는 것으로 생각되었다. 두개내 배아종의 방사선 조사량과 조사 범위, 약물 치료에 관해서는 좀 더 연구가 필요할 것으로 생각된다.

부인암 환자의 말초신경병증과 삶의 질

정주현 ( Ju Hyeon Jeong ),노주희 ( Ju Hee Nho ),김기숙 ( Gi Suk Kim ),이영은 ( Young Eun Lee ),유선영 ( Sun Young Yu ),이현주 ( Hyun Ju Lee ),심유미 ( Yu Mi Sim ),이영선 ( Young Sun Lee ) 여성건강간호학회 2013 여성건강간호학회지 Vol.19 No.4

Purpose: The purpose of this study was to identify chemotherapy induced peripheral neuropathy, quality of life of patients with gynecologic cancer. Methods: This was a cross-sectional survey design. We collected 130 patients with gynecologic cancer. They complete a self reported questionnaire including items related neuropathy and quality of life (FACT-GOG/Ntx subscale, FACT-G scale). Results: The neuropathy score was 14.3±7.9. The quality of life score was 64.8±16.4. The neuropathy induced significant difference according to diabetic status, difficulties in performing household chores and willing to discontinuity of chemotherapy. And duration of cancer diagnosis, neuropathy,number of total chemo agent associated with quality of life. There was a negative correlation between number of total chemo agent and quality of life. Neuropathy independently affected quality of life. Conclusion: Chemotherapy induced peripheral neuropathy of patients with gynecologic cancer adversely affected women`s quality of life and activities of daily living. To improve patient`s quality of life, it is important that accurate assess and appropriately manage neuropathy in patients with gynecologic cancer

비인두강 종양의 방사선치료성적

노영주(Young Ju Nho),조정길(Jeong Gill Cho),안승도(Seung Do Ahn),최은경(Eun Kyung Choi),김종훈(Jong Hoon Kim),강원철(One Chul Kang),장혜숙(Hyesook Chang) 대한방사선종양학회 1997 Radiation Oncology Journal Vol.15 No.4

목 적 : 비인두강종양의 방사선치료의 결과를 후향적으로 분석하여 방사선치료의 효과와 예후인자를 분석하고자 하였다. 대상 및 방법 : 1989년부터 1996년까지 서울중앙병원에서 비인두강종양으로 진단받고 근치적 방사선치료를 시행한 56명을 대상으로 하였다. 병기별로 보면 T1, T2, T3, T4가 각각 17, 10, 11, 18명이었고 N0, N1, N2, N3가 각각 11명, 27명, 4명, 14명이었다. 근치적 방사선치료만 시행한 환자는 28명, 유도항암요법을 병용한 환자는 7명, 매주 CDDP 항암요법을 병용한 환자는 21명이었다. 조사량은 6940-8620cGy였고 중앙값은 7440cGy였다. 외부방사선조사 60Gy이후 원발병소에 대한 부가적치료는 1명은 외부방사선조사, 46명은 강내조사, 9명은 삼차원 입체조형치료를 받았다. 추적관찰기간은 5-92개월이었고 중앙값은 34개월이었다. 결 과 : 전치료후 47명은 완전관해, 8명은 부분관해, 1명은 무반응을 보였다. 5년 생존율은 67.2%, 5년 무병생존율은 53.6%이였다. 국소재발이 생긴 시기는 6-45개월(중앙값 : 14개월)이었으며 전신적 전이가 생긴 시기는 3-49개월(중앙값 : 16개월)이었다. 8명의 환자(14.3%)에서 국소재발이 발생하였고 18명의 환자(32.1%)에서 전신적 전이가 발생하였다. T3나 T4 환자 중 강내조사를 받은 20명중 4명(20%)에서 원발병소에 재발이 있었고 삼차원 입체조형치료를 받은 9명 중 1명(11%)에서 원발병소에 재발이 발생하였다. 전신적 전이는 골전이가 가장 많았다. 생존율에 영향을 주는 예후인자로는 생존율에는 KPS( P=0.005), 방사선치료에 대한 반응(P=0.0001)이 통계학적으로 유의하였고 무병생존율에는 KPS(P=0.02), 방사선치료에 대한 반응(P=0.005)이 통계학적으로 유의하였다. 국소재발과 관련있는 예후인자는 없었으며 원격전이와 관련있는 예후인자는 N stage(P=0.06), 병기(P=0.06)가 다소 의미있는 경향을 보였고, 방사선치료에 대한 반 응(P=0.009)이 통계학적으로 유의하였다. 결 론 : 비인두강종양에서 방사선치료로 5년생존율 67.2%이었고 5년 무병생존율은 53.6%이였다. 재발양상을 보면 국소재발보다는 전신적 전이율이 높음을 알 수 있었고 항암치료와의 병용은 관련이 없었다. T3 혹은 T4 병기에서 삼차원 입체조형치료를 받은 환자에 대해서는 앞으로 추적관찰이 좀더 필요할 것으로 생각된다. 앞으로 국소관해를 높이기 위한 방사선치료방법과 전신적 전이율의 감소를 위한 항암요법에 관한 연구가 필요할 것으로 생각된다. Purpose : This is a retrospective study to evaluate the results of radiation therapy and prognostic factors influencing the results in nasopharyngeal carcinoma. Materials and Methods : From October 1989 to May 1996, 56 patients were treated for nasopharyngeal carcinoma at Department of Radiation Oncology. According to stage, patients were distributed as follows : stage I (2), II (13), III (11), IV (30). Twenty-eight patients were treated with radiation therapy only, 7 patients were treated with neoadjuvant chemotherapy followed by radiation therapy. Twenty-one patients were treated with radiation therapy and weekly CDDP. After external beam radiotherapy of 60Gy, 46 patients received boost dose with intracavitary radiation and 9 patients with 3D conformal therapy. One patient received boost dose with 2 dimensional photon beam therapy. The tumor dose ranged from 69.4Gy to 86.2Gy with median dose of 74.4Gy. The follow -up period ranged from 5 months to 92 months with a median of 34 months. Results : Forty-seven patients achieved complete response and 8 patients showed partial response. One patient showed minimal response. Patterns of failure were as follows : locoregional recurrence (8) and distant metastasis (18). Among these patients, 2 patients failed locoregionally and distantly. The sites of distant metastasis were bone (8), lung (8) and liver (4). Five years survival rate was 67.2% and 5 years disease-free survival rate was 53.6%. KPS (P=0.005) and response of radiation therapy (P=0.0001) were significant prognostic factors for overall survival. KPS (P=0.02) and response of radiation therapy (P=0.005) were significant prognostic factors for disease-free survival. Conclusion : This retrospective study showed that distant metastasis was the predominant pattern of relapse in nasopharyngeal cancer. Neoadjuvant chemotherapy or weekly CDDP did not influence the distant metastasis-free survival. For advanced T stage, 3D conformal therapy provided an improved dose coverage compared to ICR. But further follow -up was needed in patients with 3D conformal therapy to assess the efficacy of this therapy. Development of techniques of radiation therapy to improve locoregional control and of more effective systemic chemotherapy regimen are needed.

Development of gnotobiotic miniature pig isolators

Young Ah Lee,Yoon Ju Cho,Jong-In Kim,Jae won Lee,Hyun-Jhung Jhun,Byeong Han Lee,Whan Gook Nho,Jin Soo Han 한국실험동물학회 2008 한국실험동물학회 학술발표대회 논문집 Vol.2008 No.-

Analysis of Various Physiological Values in Gnotobiotic Isolator for Miniature Pigs

Young Ah Lee(이영아),Yoon Ju Cho,Jong-In Kim,Jae won Lee,Byeong Han Lee,Whan Gook Nho,Jin Soo Han 한국실험동물학회 2009 한국실험동물학회 학술발표대회 논문집 Vol.2009 No.2

Establishment of Conditions for Long-Term Maintenance of Primary Embryonic Cell Cultures from Olive Flounder Paralichthys olivaceus

Ju-Won Kim,Ja Young Cho,Dong-Gyun Kim,Bo-Hye Nam,Eun-Soo Nho,Bong-Seok Kim,Young-Ok Kim,Hee Jeong Kong 한국발생생물학회 2020 발생과 생식 Vol.24 No.3

Primary cell culture is a sufficient method frequently used to study the cellular properties and mechanisms of isolated cells in a controlled environment. In this study, an embryonic cell line (FGBC8) derived from the blastula stages of embryos of olive flounder Paralichthys olivaceus was developed. Furthermore, conditions for optimal long-term maintenance of this primary embryonic cell culture were investigated. Morphologically, FGBC8 cells were composed primarily of epithelial-like cells. FGBC8 cells were subcultured for >160 passages over ~830 days. The doubling time of FGBC8 cells was 73.8 h, and the modal diploid chromosome number was 48. FGBC8 cells transfected with green fluorescence protein (GFP)-expression plasmid exhibited a strong signal 48 h after transfection. Consequently, we demonstrated that fish serum is a crucial supplement for the long-term survival and maintenance of comparable morphology in these primary embryonic cells. Our results can be used as a guide for primary embryonic cell cultures for other fish species and may be useful for cell biotechnological applications.

Development of Isolators for Gnotobiotic Miniature Pig

Young Ah Lee,Yoon Ju Cho,Jong-In Kim,Jae Won Lee,Byeong Han Lee,Whan Gook Nho,Jin Soo Han 한국실험동물학회 2009 Laboratory Animal Research Vol.25 No.3

Miniature pigs have been marked as a source of providing organs for xenotransplantation because they are similar with humans in the physiological structure, organ size and physiological state. Though the demands for gnotobiotic pigs are increasing by the rise of bio-organic researches, there are currently few facilities for producing miniature pigs gnotobiotically. Therefore the isolator only for the miniature pigs is essential for a production and study of the gnotobiotic miniature pigs. By utilizing the isolator for gnotobiotic miniature pigs, caretakers don't have to take complicated sterilization or pasteurization steps, and thus it reduces the risk of contamination. And it is further expected to have economically positive effects by reducing costs compared to a small scaled gnotobiotic breeding facility. We developed two models of isolator and applied to patents. Weighing balance and partition were installed in the isolator to perform the body weight and temperature measurement, injection and blood-collection more comfortably without any contamination, and it could minimize the stress of animal. It is easy and comfortable to handle miniature pigs using these isolators and expected to be very useful for the study of gnotobiotic pigs.

대한예수교장로회총회(합동측) 교육과정의 현재와 미래 : The Hapdong Denomination

노영주 한국기독교교육정보학회 2003 기독교교육정보 Vol.6 No.-

The purpose of this study is to research the history of curriculum in presbyterian denomination. It is very important to understand the present and future of educational issues and to develop the entire curriculum of presbyterian denomination. Therefore, in this study, we can include this contents. Firstly, to develop the entire curriculum of presbyterian denomination, we try to understand and use the Bible in curriculum. The Bible is a central source in christian curriculum because the basic purpose cannot be realized except through an understanding of its contents. Secondly, to make idealistic curriculum of presbyterian denomination, we must be drawn by the Hory Spirit to be awakened to seek faith in God and life according to the Word. Christian curriculum deals with faith and life of learners. In Bible, we act, talk, live. Consequently, we must concentrate that curriculum of presbyterian denomination must be balanced between faith and life. Thirdly, excellent curriculum include various materials for all people who work in urban or rural and with toddlers or adults. So, curriculum of presbyterian denomination have to develop many materials for diverse contexts.

부인암 여성의 성생활에 대한 서술적 연구

노주희 ( Ju Hee Nho ),박영숙 ( Young Sook Park ) 여성건강간호학회 2012 여성건강간호학회지 Vol.18 No.1

Purpose: This study aimed to identify sexuality for women with gynecological cancer. Methods: A total of seven women with gynecological cancer agreed to participate in this study. The data were collected utilizing in-depth semistructured interviews style. A descriptive study design was used in this study. The interviews were analyzed using inductive content analysis methodology. Results: Three themes identified were: ``women with gynecological cancer who give up their sexual life due to misunderstanding and fear``, ``women with gynecological cancer who control their body and mind for recovery``, ``women with gynecological cancer resume their sexual life with their partner`s will``. Conclusion: To improve sexual health and quality of life for women with gynecological cancer, we need to develop programs related to sexual health. An adjusted sexual health program will contribute to increased sexual health and quality of life for women with gynecological cancer.

므네모시네 : 클라우드를 통한 기억의 확장

노영남(Nho Young-Nam),문철주(Moon Cheol-Ju),이유완(Lee Yue Wan),오하요(Oh Ha-Yo),홍정민(Hong Jeong Min) 한국HCI학회 2020 한국HCI학회 학술대회 Vol.2020 No.2