Chemical constituents of the Annona glabra fruit and their cytotoxic activity.

Hien, Nguyen Thi Thu,Nhiem, Nguyen Xuan,Yen, Duong Thi Hai,Hang, Dan Thi Thuy,Tai, Bui Huu,Quang, Tran Hong,Tuan Anh, Hoang Le,Kiem, Phan Van,Minh, Chau Van,Kim, Eun-Ji,Kim, Seung Hyun,Kang, Hee Kyoun Swets Zeitlinger 2015 PHARMACEUTICAL BIOLOGY Vol.53 No.11

<P>Traditional Chinese medicines have attracted increasing interest as potential sources of novel drugs with a wide range of biological and pharmacological activities. Annona glabra Linn (Annonaceae) is used in traditional medicine as an anticancer drug. Phytochemical investigation of this plant led to the isolation of acetogenins, ent-kauranes, peptides, and alkaloids. In addition, compounds exhibited anticancer, anti-HIV-reserve, and antimalaria.</P>

Invasive Non-typhoidal <i>Salmonella</i> Infections in Asia: Clinical Observations, Disease Outcome and Dominant Serovars from an Infectious Disease Hospital in Vietnam

Phu Huong Lan, Nguyen,Le Thi Phuong, Tu,Nguyen Huu, Hien,Thuy, Le,Mather, Alison E.,Park, Se Eun,Marks, Florian,Thwaites, Guy E.,Van Vinh Chau, Nguyen,Thompson, Corinne N.,Baker, Stephen Public Library of Science 2016 PLoS neglected tropical diseases Vol.10 No.8

<▼1><P>Invasive non-typhoidal <I>Salmonella</I> (iNTS) infections are now a well-described cause of morbidity and mortality in children and HIV-infected adults in sub-Saharan Africa. In contrast, the epidemiology and clinical manifestations of iNTS disease in Asia are not well documented. We retrospectively identified >100 cases of iNTS infections in an infectious disease hospital in Southern Vietnam between 2008 and 2013. Clinical records were accessed to evaluate demographic and clinical factors associated with iNTS infection and to identify risk factors associated with death. Multi-locus sequence typing and antimicrobial susceptibility testing was performed on all organisms. Of 102 iNTS patients, 71% were HIV-infected, >90% were adults, 71% were male and 33% reported intravenous drug use. Twenty-six/92 (28%) patients with a known outcome died; HIV infection was significantly associated with death (<I>p</I> = 0.039). <I>S</I>. Enteritidis (Sequence Types (ST)11) (48%, 43/89) and <I>S</I>. Typhimurium (ST19, 34 and 1544) (26%, 23/89) were the most commonly identified serovars; <I>S</I>. Typhimurium was significantly more common in HIV-infected individuals (<I>p</I> = 0.003). Isolates from HIV-infected patients were more likely to exhibit reduced susceptibility against trimethoprim-sulfamethoxazole than HIV-negative patients (<I>p</I> = 0.037). We conclude that iNTS disease is a severe infection in Vietnam with a high mortality rate. As in sub-Saharan Africa, HIV infection was a risk factor for death, with the majority of the burden in this population found in HIV-infected adult men.</P></▼1><▼2><P><B>Author Summary</B></P><P>Invasive non-typhoidal <I>Salmonella</I> (iNTS) infections occur when <I>Salmonella</I> bacteria, which normally cause diarrhea, enter the bloodstream and spread through the body. Invasive NTS infections have become a common cause of infection and death in children with malaria and adults with HIV in sub-Saharan Africa. However, it is unknown whether iNTS is as common or as severe outside sub-Saharan Africa. We evaluated over 100 iNTS cases from an infectious disease hospital in southern Vietnam admitted between 2008–2013. We used hospital records to determine the clinical features of iNTS disease and to identify risk factors associated with death and performed typing of the isolated organisms. The majority of patients were HIV positive (72/102, 71%), >90% of patients were adults, 71% were male and 33% reported intravenous drug use. The mortality rate of iNTS patients was 28% (26/92), and HIV infection was a significant risk factor for fatal outcome (<I>p</I> = 0.039). The serovars most commonly identified were <I>S</I>. Enteritidis and <I>S</I>. Typhimurium; <I>S</I>. Typhimurium was found more frequently in HIV-positive individuals (<I>p</I> = 0.003). We report that iNTS disease is a severe infection in Vietnam with a high mortality rate. Similar to sub-Saharan Africa, HIV infection was a strong risk factor for death.</P></▼2>

Compliance of education journals in Vietnam with the minimum criteria to be indexed in the ASEAN Citation Index and Scopus

Trung Tran,Loc Thi My Nguyen,Thanh Thi Nghiem,Hien Thi Thu Le,Cuong Huu Nguyen,Thuy Phuong La,Trung Tien Nguyen,Hang Thi-Thu Nguyen 한국과학학술지편집인협의회 2019 Science Editing Vol.6 No.2

This study aimed at elucidating the present situation of scholarly journals published in Vietnam according to the minimum criteria to be indexed in the ASEAN Citation Index (ACI) and Scopus, with the goal of suggesting development strategies for scholarly journals in Vietnam. From the 387 journals accredited by the Vietnamese State Council for Professorship, 13 education journals were arbitrarily selected, and their compliance with the five minimum criteria for the ACI (peer review, timeliness, abstracts in English, references in Roman script, and a website in English) and the six minimum criteria for Scopus (peer review, timeline, abstracts in English, references in Roman characters, Electronic International Standard Serial Number [ISSN], and publication ethics) were assessed. Two of the 13 journals were eligible to be indexed in the ACI, while none fulfilled the minimum criteria to be indexed in Scopus. An urgent task for the editors of those journals is to establish an informative journal homepage in English that provides basic information on the journal. Then, an Electronic ISSN can be obtained from the ISSN International Center. Furthermore, the following steps are suggested for journal promotion: establishment of appropriate editorial policies and publication ethics procedures, improvement of research integrity, enhancement of the journals’ reputation in the international scientific community, and improvement of the online publishing system by adopting a journal manuscript management system. To achieve those goals, financial support from the Vietnamese government will be invaluable.

Joint-training programs in Vietnam: operation and quality management aspects gathered from institutional practices

Nguyen, Cuong Huu,Nhan, Thuy Thi,Ta, Hien Thu Thi 서울대학교 교육연구소 2021 Asia Pacific Education Review Vol.22 No.2

This study examines joint-degree training in a higher education context in Vietnam, especially its different operation and quality management aspects. First, it reviews program mobility in international practices, from which it identifies critical requirements for maintaining quality and sustainable transnational partnerships. It then discusses the rationales, government policies, recent developments, and key issues related to joint-degree training operations in Vietnam. Using data collected from administrators, teaching staff, and students of selected Vietnamese universities who are involved in delivering collaborative programs, this study further explains management, teaching, learning, and quality assurance aspects and provides implications for local institutions, academics, and students engaged in cross-border partnerships.

Chemical constituents of Trichosanthes kirilowii and their cytotoxic activities

Chau Van Minh,Nguyen Xuan Nhiem,Hoang Thi Yen,Phan Van Kiem,Bui Huu Tai,Hoang Le Tuan Anh,Truong Thi Thu Hien,박선주,김나영,김승현 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.8

One new lignan, trichobenzolignan (1), and seven known compounds, ligballinol (2), (-)-pinoresinol (3), ehletianol C (4), luteolin 7-O-b-D-glucopyranoside (5), chrysoeriol-7- O-b-D-glucopyranoside (6), 10a-cucurbita5,24-dien-3b-ol (7), and arvenin I (8). Their structures were established on the basis of spectral and chemical evidence, which were in agreement with those reported in literature. The cytotoxic activities of these compounds were evaluated on four cancer cell lines such as A-549 (human lung cancer), HT-29 (human colon adenocarcinoma), OVCAR (human ovarian carcinoma), and MCF-7 (human breast cancer). As the results, compound 7 showed significant activity on HT-29 and OVCAR cancer cell lines with IC50 of 4.1 and 6.5 lM, respectively. Compounds 1, 5, 6, and 8 exhibited moderate activities in all cancer cell lines with IC50 ranging from 11.3 to 42.8 lM.

Recent advances in two-dimensional transition metal dichalcogenides-graphene heterostructured materials for electrochemical applications

Thanh, Tran Duy,Chuong, Nguyen Dinh,Hien, Hoa Van,Kshetri, Tolendra,Tuan, Le Huu,Kim, Nam Hoon,Lee, Joong Hee Elsevier 2018 Progress in materials science Vol.96 No.-

<P><B>Abstract</B></P> <P>Recently, the research effort on two-dimensional transition metal dichalcogenides/graphene (2D-TMDs/Gr) hybrids has grown. These hybrids are emerging as a promising strategy for the preparation of advanced multifunctional materials with effectively upgraded properties, as well as performances. Due to their outstanding electrical, physical, and chemical properties, these materials have been extensively considered for various applications, both in academia, and industry. This review systematically assesses the important progress to date in the development of 2D-TMDs/Gr hybrids. The synthesis methods of 2D-TMDs/Gr hybrids for fabricating diverse types of nanostructured architectures are highlighted. In addition, the relationships between morphological and structural characteristics, and the physicochemical properties of 2D-TMDs/Gr hybrids, are recognized in detail. This review also discusses recent prospective applications of the 2D-TMDs/Gr hybrids in the areas of energy storage, energy conversion, energy harvesting technologies, and sensors. In summary, although there are still challenges for optimizing the synthesis process and performance of the 2D-TMDs/Gr hybrids, they offer unique candidates for a wide range of promising applications in the future.</P>

The Effect of Foreign Direct Investment Inflow on Exports: Evidence from Vietnam

Duc Anh DO,Yinghua SONG,Huu Tung DO,Thi Thu Hien TRAN,Thanh Thuy NGUYEN 한국유통과학회 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.2

Foreign direct investment (FDI) and export are now often regarded as two of the most important drivers of economic growth on a worldwide scale. The impact of foreign direct investment on Vietnam’s exports is investigated in this study. The data for the time period 1985–2020 was obtained from the World Bank and the Vietnam General Statistics Office. The years 1985 to 2020 were chosen to evaluate the evolution of macroeconomic parameters since 1986. The impact of the Covid-19 epidemic on renovation reform. The Johansen co-integration test proved that FDI and domestic investment (DI) had a long-term positive impact on Vietnam’s export growth. The Granger causality test revealed that there is a one-way relationship between FDI and export in the near term, but no such relationship exists between DI and export. The result of the variance decomposition study demonstrates that the FDI sector has a bigger impact on Vietnam’s export growth than the DI sector. Furthermore, export activities are vulnerable to FDI sector shocks. As a result, in recent years, FDI has been regarded as the most important factor of export growth in Vietnam.

Antibiotic-Resistant Gram-negative Bacteria Carriage in Healthcare Workers Working in an Intensive Care Unit

Duong Bich Thuy,Duong Minh Cuong,Campbell James,Nguyen Van Minh Hoang,Nguyen Huu Hien,Bui Thi Bich Hanh,Nguyen Van Vinh Chau,McLaws Mary-Louise 대한감염학회 2021 Infection and Chemotherapy Vol.53 No.3

Little is known about antibiotic-resistant Gram-negative bacteria (GNB) intestinal carriage among healthcare workers (HCWs) in Vietnam. All HCWs at a tertiary intensive care units were asked to undertake weekly rectal swabs. Among 40 participants, 65% (26/40) carried extended spectrum β-lactamases (ESBL)/AmpC β-lactamase-producing Escherichia coli. Two HCWs colonized with ESBL/AmpC β-lactamase-producing Klebsiella pneumoniae. One HCW colonized with Acinetobacter baumannii. No one carried Pseudomonas spp.. A quarter (10/40) of HCWs were identified as persistent and frequent carriers. There is an urgent need to screen antibiotic-resistant GNB among HCWs and improve HCWs’ hand hygiene compliance to reduce the transmission of antibiotic-resistant GNB in the hospital.