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Navanietha Krishnaraj Rathinam,Chandran Saravanan,Pal Parimal,Varalakshmi Perumal,Malliga Perumal 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.5
Graphene draws considerable attention among biomedical researchers because of its unique physical, chemicaland biological properties. The wide applications of graphene in the biomedical arena such as diagnostics, drug immobilizationand drug delivery were well documented in the literature. However the therapeutic potential of the graphenetowards retroviruses and the interactions of the graphene with receptors/proteins are still unexplored. Herein we reportthe antagonistic molecular interactions of graphene with the three key target proteins of HIV infections namely HIVVpr,Nef and Gag proteins. The docking investigations were performed to find the binding energy of the graphene ligandsto the key target proteins of HIV. The high binding affinity of the graphene to these proteins indicates the antagonisticmolecular interaction of graphene to the disease targets. The therapeutic potential of graphene was also studied by changingthe size and the number of layers of the graphene. The experimental results confirm the good therapeutic potential ofthe graphene to combat HIV mediated retroviral infections.
Muralidharan Murugan,Sangiliyandi Gurunathan,Kevin John Pulikotil Anthony,Muniyandi Jeyaraj,Navanietha Krishnaraj Rathinam 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4
In this paper, a simple and environmentally friendly method for synthesis of gold nanoparticles (AuNPs) using culture supernatant of Bacillus flexus as reductants and stabilizers is reported. The prepared AuNPs were characterized by various analytical techniques. UV–visible spectroscopy, X-ray diffraction (XRD), energy dispersive X-ray spectroscopy (EDS) results confirmed that Au3+ ions reduced into Au0. Fourier-transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) measurements confirmed that the chemical surface structure of AuNPs. TEM images showed the size and morphology of AuNPs. Moreover, the toxicity studies suggested that AuNPs were neither toxic nor inhibitory to human breast cancer cells (MCF-7).
Kevin John Pulikotil Anthony,Muralidharan Murugan,Muniyandi Jeyaraj,Navanietha Krishnaraj Rathinam,Gurunathan Sangiliyandi 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4
Here we described, cost effective, green and environmentally friendly approach for synthesis of AgNPs using edible pine mushroom Tricholoma matsutake. The synthesized AgNPs were characterized using UV–visible spectroscopy, particle analyzer and X-ray diffraction. Furthermore, Fourier transform infrared spectroscopy (FTIR) measurements were carried out to identify the possible biomolecules responsible for capping and efficient stabilization of the nanoparticles. The size and morphology of nanoparticles were analyzed by transmission electron microscopy (TEM). In addition, the antimicrobial activity of as prepared AgNPs was investigated against Escherichia coli and Bacillus subtilis using the agar diffusion method.