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      • Pu-erh Tea Powder Preventive Effects on Cisplatin-Induced Liver Oxidative Damage in Wistar Rats

        Zheng, Xiao-Nan,Wang, Xiao-Wen,Li, Li-Ya,Xu, Zi-Wei,Huang, Hsin-Yi,Zhao, Jin-Sheng,Zhang, Duo,Yin, Xu,Sheng, Jun,Tang, Jin-Tian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17

        Background: Chemotherapy is one of the major means for control of malignancies, with cisplatin (CDDP) as one of the main agents, widely used for the treatment of various malignant solid tumors. However, prevention of hepatotoxicity from cisplatin is one of the urgent issues in cancer chemotherapy. In this study, we aimed to investigate the effects of pu-erh tea on hepatotoxicity through body weight and tissue antioxidant parameters like, liver coefficient, serum alanine aminotransferase (ALT), serum aspartate aminotransferase (AST), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), malondialdehyde(MDA) and glutathione (GSH) levels, and light microscopic evaluation by histological findings. Materials and Methods: The rats were randomly divided into five groups: Control (n=10), cisplatin (3 mg/kg p.i., n=10), cisplatin+pu-erh (0.32 g/kg/day i.g., n=10), cisplatin+pu-erh (0.8 g/kg/day i.g., n=10) and cisplatin+pu-erh (1.6 g/kg/day i.g., n=10). Pu-erh tea powder was administrated for 31 consecutive days. The rats were sacrificed at the end on the second day after a single dose of cisplatin treatment for measuring indices. Results: Pu-erh tea powder exhibited a protective effect by decreasing MDA and GSH and increasing the SOD and GSH-PX levels and GSH-PX/MDA ratio in camparison with the control group. Besides, pu-erh tea was also able to alleviate the pathological damage to some extent. Conclusion: Pu-erh tea powder is protective against cisplatin-induced liver oxidative damages, especially at the medium dosage (0.8 g/kg/d).

      • KCI등재

        Study on temperature characteristics of gasoline engine particulate filters during fuel cut-off

        Nan Li,Zheng Nan,Qiushi Zhang,Haitao Liu,Lun Hua,Caihong Zhang 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.12

        Based on the bench test of a 1.5 L gasoline engine equipped with a catalytic gasoline engine particulate filter(CGPF), the fuel cut-off regeneration characteristics of the next generation with small pore size GPF and the commonGPF under different soot loading and temperatures were studied. The results showed that after the fuel was cutoffduring the regeneration process, the center temperature of the sample rose exponentially, and as the regenerationtime extended, the temperature gradually became flat. The temperature distribution inside the carrier was such that theinlet temperature was low at the axial position, and the temperature near the outlet was high, the radial position showeda trend of high temperature in the middle and low temperature at the edge, and the temperature difference betweenthe edge and the center of the carrier was large. The maximum temperature inside the GPF increased with the increasein soot loading, and the maximum temperature gradient also increased. When the soot loading reached 6 g/L and thefuel cut-off regeneration was conducted at 650 oC, the maximum and maximum temperature gradient inside the GPFexceeded the tolerance limit of the GPF, and the inside of the carrier was damaged to varying degrees. Therefore, theseparameters should be controlled during regeneration.

      • Helicobacter Pylori CagA and Gastric Carcinogenesis

        Zheng, Ri-Nan,Li, Shu-Rong,Masahiro, Asaka Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.12

        Objectives: This study aimed to demonstrate the tyrosine phosphorylation motif (TPM) and 3' region structure of the Helicobacter pylori CagA gene as well as its SHP-2 binding activity in AGS cells and relation to gastric carcinogenesis. Methods: Sixteen clinical isolate H. pylori strains from eight duodenal ulcer and eight gastric adenocarcinoma patients were studied for CagA repeat sequence EPIYA motifs, C-terminal structure, and western blot analysis of CagA protein expression, translocation, and SHP-2 binding in AGS cells. Results: Except for strain 547, all strains from the gastric adenocarcinoma patients were positive for CagA by PCR and had three EPIYA copy motifs. Western blotting showed that all strains were positive for CagA protein expression (100%), CagA protein translocation (100%), and SHP-2 binding (100%). CagA protein expression was significantly higher in the gastric adenocarcinoma patients than in the duodenal ulcer patients (P=0.0023). CagA protein translocation and SHP-2 binding in the gastric adenocarcinoma patients were higher than those in the duodenal ulcer patients, but no significant differences were found between the two groups (P=0.59, P=0.21, respectively). Conclusions: The TPMs and 3' region structures of the H. pylori CagA gene in the duodenal ulcer and gastric adenocarcinoma patients have no significant differences.

      • 중국 노인 여가스포츠 참가자의 참여동기와 행복에 관한 연구

        정원남(Zheng Yuan Nan),홍미화(Hong Mi Hwa),최영래(Choi Young Lae) 글로벌시니어건강증진개발원 2011 글로벌시니어건강증진개발원 논문집 Vol.1 No.1

        본 연구는 중국 노인 여가스포츠 참가자의 참여동기와 행복의 관계에 관한 선행연구 결과를 기초로 하여 인구학적 특성에 따른 여가스포츠 참여동기, 행복의 차이를 실증적으로 규명하는데 목적이 있다. 이와 같은 연구목적을 달성하기 위하여 2011년 현재 중국 북경시에 살고 있는 만 65세 이상의 여가스포츠에 참가하고 있는 노인을 모집단으로 선정한 다음 집락무선표집법(Cluster Random Sampling Method)을 이용하여 표본을 500부 추출하였으며, 불성실하게 응답한 자료를 제외하고 총 460명의 자료를 최종분석에 사용하였다. 자료처리는 SPSS Windows 17.0 version을 이용하여 빈도분석, 탐색적 요인분석, 신뢰도분석, T검정, One-way Anova를 실시하였으며, 다음과 같은 결론을 도출하였다. 첫째, 인구학적 특성에 따른 여가스포츠 참여동기 차이에서는 성별은 남자가 여자보다 외적동기가 높게, 연령은 75세 이상 노인들의 65~74세 노인들보다 내적동기가 높게, 배우자 유무에서는 내적동기와 외적동기가 배우자 있다가 없다보다 높게, 용돈정도에서는 외적동기와 내적동기 모두 넉넉함이 많이부족 보다 높게, 주관적 건강에서는 건강한 노인들이 건강하지 않은 노인들보다 내적동기가 높게 나타났다. 둘째, 인구학적 특성에 따른 여가스포츠 행복의 차이에서는 성별은 여자가 남자보다 행복감이 높게, 연령에서는 생활만족이 65~69세가 70세이상 보다 높게, 행복감은 75세 이상이 65~74세 노인들 보다 높게, 교육수준에서는 대졸·고졸·중졸이 초졸 보다 높게, 배우자 유무에서는 생활만족과 행복감 모두 배우자 있다가 없다 보다 높게, 용돈정도는 생활만족과 행복감 모두 넉넉함이 많이 부족보다 높게 나타났다. The purpose of this study is to proven investigate of participation motivation and leisure constraints of Chinese elderly who participating in leisure sport through precede studies. To attain this purpose, we selected the populations who lived in Beijing, China, in 2011 and more than 65 ages, and participating in leisure sport regularly. fter the process, we extract 500 samples by ‘Cluster Random Sampling’ method. onsequently, we used 460 samples data for our study. SPSS Windows 17.0 version was used for statistical analysis. hrough this program, we conducted frequency analysis, exploratory-factorial analysis, reliability analysis, t-test, One-way ANOVA. he result of our study is as in the following. First of all, in part of demographic factors, external motivation of male was higher than that of female. Internal motivation of the upper 75 ages was higher than those of 65 to 74 ages. nternal and external motivations of the elderly who have spouse were higher than that of who don’t have their spouse. In spending money part, internal and external motivations were higher in abundant person than relatively the poor. In self awareness of physical fitness, internal motivation of healthy person was higher than the unhealthy. Second, the degrees of happiness of female were higher than male in accordance with demographic factors (gender). In life satisfaction part, 65 to 69 ages were higher than upper 70 ages. However, the degrees of happiness of upper 75 ages were higher than that of 65 to 74 ages. The persons who have diploma of college, high school, middle school were higher in life satisfaction than who don’t have. As stated above, the elderly who have spouse were higher in life satisfaction and happiness than that of who don’t have their spouse. And lastly, in spending money part, life satisfaction and happiness were higher in abundant person than relatively the poor.

      • KCI등재
      • Tumor-Derived Transforming Growth Factor-β is Critical for Tumor Progression and Evasion from Immune Surveillance

        Li, Zheng,Zhang, Li-Juan,Zhang, Hong-Ru,Tian, Gao-Fei,Tian, Jun,Mao, Xiao-Li,Jia, Zheng-Hu,Meng, Zi-Yu,Zhao, Li-Qing,Yin, Zhi-Nan,Wu, Zhen-Zhou Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13

        Tumors have evolved numerous mechanisms by which they can escape from immune surveillance. One of these is to produce immunosuppressive cytokines. Transforming growth factor-${\beta}$(TGF-${\beta}$) is a pleiotropic cytokine with a crucial function in mediating immune suppression, especially in the tumor microenvironment. TGF-${\beta}$ produced by T cells has been demonstrated as an important factor for suppressing antitumor immune responses, but the role of tumor-derived TGF-${\beta}$ in this process is poorly understood. In this study, we demonstrated that knockdown of tumor-derived TGF-${\beta}$ using shRNA resulted in dramatically reduced tumor size, slowing tumor formation, prolonging survival rate of tumor-bearing mice and inhibiting metastasis. We revealed possible underlying mechanisms as reducing the number of myeloid-derived suppressor cells (MDSC) and $CD4^+Foxp3^+$ Treg cells, and consequently enhanced IFN-${\gamma}$ production by CTLs. Knockdown of tumor-derived TGF-${\beta}$ also significantly reduced the conversion of na$\ddot{i}$ve $CD4^+$ T cells into Treg cells in vitro. Finally, we found that knockdown of TGF-${\beta}$ suppressed cell migration, but did not change the proliferation and apoptosis of tumor cells in vitro. In summary, our study provided evidence that tumor-derived TGF-${\beta}$ is a critical factor for tumor progression and evasion of immune surveillance, and blocking tumor-derived TGF-${\beta}$ may serve as a potential therapeutic approach for cancer.

      • KCI등재

        한국과 중국 대학운동선수들의 스포츠가치관 비교연구

        정원남(Zheng, Yuan-Nan),원영신(Won, Young-Shin),최영래(Choi, Young-Lae) 한국체육과학회 2011 한국체육과학회지 Vol.20 No.6

        The purpose of this study was to analyze the differences in point of view of sports values for university athletes in China and Korea, and to prove the existence of these differences through their personal characteristics. SPSS Windows 17.0 version was used for processing the date of the research. The results of this study are as follows: First, as to the difference of universities athletes’ values in different countries, it appeared that Chinese athletes were higher than Korean athletes in terms of economic value, social relation value and character value. Second, Korean athletes with different personal characteristics showed a significant difference in terms of economic value, character value and psychological value in regards to sports. Third, Chinese athletes showed a difference in social relation value and character value. In regards to the relationship of gender to this equation, gender was shown to be a source of significant differences in social relation value, the athletes’ experience caused economic value, the social relation value, character value and religious value. Finally, the influence of winning a prize was a difference in social relation value and psychological value.

      • 중국 대학운동선수들의 스포츠가치관이 진로결정유형에 미치는 영향

        정원남 ( Yuan Nan Zheng ),원영신 ( Young Shin Won ) 연세대학교 체육연구소 2010 체육연구논문집 Vol.17 No.1

        The purpose of this study is to analyze how the sports values have effects on deciding what the chinese college athletes do after their graduation. To proceed this study, we set 310 university students who are athlete for our research target in Beijing. Some questionnaires were used for research and we do exploratory factor analysis, reliability analysis, correlation analysis and multiple liner regression through SPSS 17.0 Version for data processing. The results of this research is as below. In the relationship between chinese athletes`s sports values and types of career decision. characteristic, economic, political, religious, entertainment values a give meaningful effect to the rational decision, economic and religious values give a meaningful effect to the dependent decision, and characteristic, political and religious values give a meaningful effect to intuitional decision.

      • SNS상의 온라인 구전정보 특성 및 브랜드 이미지가 구매의도에 미치는 영향 - 중국 SNS상의 한국 화장품 브랜드를 대상으로 -

        정천남 ( Qian Nan Zheng ),노원희 ( Won Hee Noh ) 한국유통물류정책학회 2016 유통물류연구 Vol.3 No.1

        온라인 구전이 소비자의 구매의도에 영향을 미치는 것은 많은 선행연구에서 이미 검증되었다. 특히, 온라인 구전이 활발하게 일어나는 원인 중 하나인 “소셜 네트워크 서비스(social network service)”는 정보를 공유하고자 하는 동기가 많은 부분을 차지하고 있다. 소비자는 온라인상에서 정보를 획득하고, 정보를 확산시키며, 정보를 생산하는 범주에서 SNS를 활용한다. 이러한 이유에서 SNS와 온라인 구전은 밀접한 관련이 있어서 이용자들 간에 정보 공유는 구매 행동에 많은 영향을 미칠 것으로 예상한다. 본 연구는 브랜드 이미지가 매개 변수로서 SNS상에 온라인 구전 정보의 3가지 특성(방향성, 수량, 내용 품질)이 소비자 구매의도에 미치는 영향을 연구하였으며, SNS상에 온라인 구전 정보의 특성, 브랜드 이미지, 소비자 구매의도 간의 관계를 검증하고자 한다. 좀 더 구체적으로 살펴보면, 본 연구에서는 SNS상에 온라인 구전 정보의 특성, 브랜드 이미지, 구매의도 간에 관계의 모델을 수립하고 중국 SNS상에 한국 화장품 브랜드의 온라인 구전 정보가 연구대상으로 중국 SNS 이용자를 조사 대상으로 하였다. 그 결과 SNS상에 온라인 구전 정보의 특성이 소비자 구매의도에 대하여 유의미한 영향을 미쳤고, SNS상에 온라인 구전 정보의 특성은 브랜드 이미지에 대하여 부분적으로만 영향을 미쳤다. 마지막으로 브랜드 이미지는 SNS상에 온라인 구전 정보의 특성과 소비자 구매의도 사이의 매개효과가 있는 것으로 나타났다. The influence of Word of Mouth on consumer purchase Intention has been unanimously approved by preceding research. Depending on the development of online economy, communication of word of mouth developed from offline to the online has been important information for consumers to reference when shopping. At the same time, more and more brand products which before were sold in offline channels is to sell through online channel, the affect of brand image on purchase intention should not be underestimated. Especially, SNS(social network service) which the reasons for the rapid development of IWOM, the information dissemination and acceptance is the main reason for use. Consumers make use of SNS to obtain information, disseminate information and product information in online. For this reason, SNS and IWOM are closely linked. So we predict that the behavior of intelligence sharing have a significant impact on the purchasing behavior among users. The study uses brand image as mediator variables to the model of the effect that IWOM in SNS puts on consumer purchase intention, and explore the relationship among the three variables: IWOM in SNS, brand image and consumer purchase intention. The study construct a relationship model of IWOM in SNS, brand image and consumer purchase intention, choice commodity cosmetics IWOM in China`s SNS as the object of study. We choice the China`s SNS users as the investigation object. The study used SPSS and AMOS to make descriptive statistics analysis, evaluation of the measurement model, confirmatory factor analysis, path analysis, mediator effect analysis. The conclusions are as follows: Firstly, IWOM in SNS has a significant positive impact on consumer purchase intention. Secondly, IWOM in SNS has a partly positive impact on brand image. Thirdly, brand image has a mediator effect in the effect that the direction of IWOM and content quality of IWOM and put on consumer purchase intention. According to the conclusions, the study put forward corresponding suggesttons: positively analyse the reason of negative word of mouth appearance and to eliminate, Implement development strategies brand image, train brand image that suitable for online marketing.

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