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영어 학습자들의 온라인 기반 영어 쓰기 자동 피드백 프로그램 사용에 대한 인식 및 학습 전략 연구
김남희 ( Kim¸ Namhee ),정미애 ( Jung¸ Mie-ae ) 글로벌영어교육학회 2021 Studies in English education Vol.26 No.3
This study explored how English learners perceive an automated feedback program, Grammarly. and how they use it for their English learning. A total of fifty-seven university students participated in the study. They were asked to report their reflections on corrective feedback on their English compositions provided by Grammarly and their strategies of using the program for their English learning. The students reported grammar errors, vocabulary errors, and punctuation errors. It was found that Grammarly was useful for checking grammar. Furthermore, they suggested a variety of English learning strategies using an automated feedback program for their English learning. Pedagogical implications are discussed based on the results.
Jung, Namhee,Park, Saeyoung,Choi, Yoonyoung,Park, Joo-Won,Hong, Young Bin,Park, Hyun Ho Choi,Yu, Yeonsil,Kwak, Geon,Kim, Han Su,Ryu, Kyung-Ha,Kim, Jae Kwang,Jo, Inho,Choi, Byung-Ok,Jung, Sung-Chul MDPI AG 2016 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.17 No.11
<P>Schwann cells (SCs), which produce neurotropic factors and adhesive molecules, have been reported previously to contribute to structural support and guidance during axonal regeneration; therefore, they are potentially a crucial target in the restoration of injured nervous tissues. Autologous SC transplantation has been performed and has shown promising clinical results for treating nerve injuries and donor site morbidity, and insufficient production of the cells have been considered as a major issue. Here, we performed differentiation of tonsil-derived mesenchymal stem cells (T-MSCs) into SC-like cells (T-MSC-SCs), to evaluate T-MSC-SCs as an alternative to SCs. Using SC markers such as <I>CAD19</I>, <I>GFAP</I>, <I>MBP</I>, <I>NGFR</I>, <I>S100B</I>, and <I>KROX20</I> during quantitative real-time PCR we detected the upregulation of <I>NGFR</I>, <I>S100B</I>, and <I>KROX20</I> and the downregulation of <I>CAD19</I> and <I>MBP</I> at the fully differentiated stage. Furthermore, we found myelination of axons when differentiated SCs were cocultured with mouse dorsal root ganglion neurons. The application of T-MSC-SCs to a mouse model of sciatic nerve injury produced marked improvements in gait and promoted regeneration of damaged nerves. Thus, the transplantation of human T-MSCs might be suitable for assisting in peripheral nerve regeneration.</P>
Jung, Namhee,Won, Jae Kyung,Kim, Baek-Hui,Suh, Kyung Suk,Jang, Ja-June,Kang, Gyeong Hoon The Korean Academy of Medical Sciences 2012 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.27 No.6
<P>DNA methylation is one of the main epigenetic mechanisms and hypermethylation of CpG islands at tumor suppressor genes switches off these genes. To find novel DNA methylation markers in hepatocellular carcinoma (HCC), we performed pharmacological unmasking (treatment with 5-aza-2'-deoxycytidine or trichostatin A) followed by microarray analysis in HCC cell lines. Of the 239 promoter CpG island loci hypermethylated in HCC cell lines (as revealed by methylation-specific PCR), 221 loci were found to be hypermethylated in HCC or nonneoplastic liver tissues. Thirty-three loci showed a 20% higher methylation frequency in tumors than in adjacent nonneoplastic tissues. Correlation of individual cancer-related methylation markers with clinicopathological features of HCC patients (n = 95) revealed that the number of hypermethylated genes in HCC tumors was higher in older than in younger patients. Univariate and multivariate survival analysis revealed that the <I>HIST1H2AE</I> methylation status is closely correlated with the patient's overall survival (<I>P</I> = 0.022 and <I>P</I> = 0.010, respectively). In conclusion, we identified 221 novel DNA methylation markers for HCC. One promising prognostic marker, <I>HIST1H2AE</I>, should be further validated in the prognostication of HCC patients.</P>
Kang, Jung-Ah,Park, Sang-Heon,Jeong, Sang Phil,Han, Min-Hee,Lee, Cho-Rong,Lee, Kwang Min,Kim, Namhee,Song, Mi-Ryoung,Choi, Murim,Ye, Michael,Jung, Guhung,Lee, Won-Woo,Eom, Soo Hyun,Park, Chul-Seung,Pa National Academy of Sciences 2016 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.113 No.31
<P>The role of cereblon (CRBN) in T cells is not well understood. We generated mice with a deletion in Crbn and found cereblon to be an important antagonist of T-cell activation. In mice lacking CRBN, CD4(+) T cells show increased activation and IL-2 production on T-cell receptor stimulation, ultimately resulting in increased potassium flux and calcium-mediated signaling. CRBN restricts T-cell activation via epigenetic modification of Kcna3, which encodes the Kv1.3 potassium channel required for robust calcium influx in T cells. CRBN binds directly to conserved DNA elements adjacent to Kcna3 via a previously uncharacterized DNA-binding motif. Consequently, in the absence of CRBN, the expression of Kv1.3 is derepressed, resulting in increased Kv1.3 expression, potassium flux, and CD4(+) T-cell hyperactivation. In addition, experimental autoimmune encephalomyelitis in T-cell-specific Crbn-deficient mice was exacerbated by increased T-cell activation via Kv1.3. Thus, CRBN limits CD4(+) T-cell activation via epigenetic regulation of Kv1.3 expression.</P>
Park, Saeyoung,Choi, Yoonyoung,Jung, Namhee,Kim, Jieun,Oh, Seiyoon,Yu, Yeonsil,Ahn, Jung-Hyuck,Jo, Inho,Choi, Byung-Ok,Jung, Sung-Chul D.A. Spandidos 2017 International journal of molecular medicine Vol.39 No.4
<P>Mesenchymal stem cells (MSCs) are capable of self-renewal and differentiation and are thus a valuable source for the replacement of diseased or damaged organs. Previously, we reported that the tonsils can be an excellent reservoir of MSCs for the regeneration of skeletal muscle (SKM) damage. However, the mechanisms involved in the differentiation from tonsil-derived MSCs (T-MSCs) to myocytes via myoblasts remain unclear. To clarify these mechanisms, we analyzed gene expression profiles of T-MSCs during differentiation into myocytes compared with human skeletal muscle cells (hSKMCs). Total RNA was extracted from T-MSCs, T-MSC-derived myoblasts and myocytes, and hSKMCs and was subjected to analysis using a microarray. Microarray analysis of the three phases of myogenic differentiation identified candidate genes associated with myogenic differentiation. The expression pattern of undifferentiated T-MSCs was distinguishable from the myogenic differentiated T-MSCs and hSKMCs. In particular, we selected FNBP1L, which among the upregulated genes is essential for antibacterial autophagy, since autophagy is related to SKM metabolism and myogenesis. T-MSCs differentiated toward myoblasts and skeletal myocytes sequentially, as evidenced by increased expression of autophagy-related markers (including Beclin-1, LC3B and Atg5) and decreased expression of Bcl-2. Furthermore, we reconfirmed that autophagy has an effect on the mechanism of skeletal myogenic differentiation derived from T-MSCs by treatment with 5-azacytidine and bafilomycin A1. These data suggest that the transcriptome of the T-MSC-derived myocytes is similar to that of hSKMCs, and that autophagy has an important role in the mechanism of myogenic differentiation of T-MSCs.</P>
Namhee Jeong,Jung-Kyung Moon,Kiwoung Yang,Hong-Sig Kim,Soon-Chun Jeong 한국작물학회 2008 한국작물학회 학술발표대회 논문집 Vol.2008 No.10
Most soybean cultivars have ovate leaflets, although a few cultivars have narrow or lanceolate leaflets. Narrow leaflet cultivars tend to have more seeds produced per pod than ovate leaflet cultivars, suggesting that the narrow leaflet trait is tightly linked to or cosegregating with the trait controlling number of seeds produced per pod (nspp). The objective of this study was to construct a high resolution map of a chromosomal region controlling narrow leaflet trait and nspp in soybean. A BC3F2 population from a cross between 'Sowonkong' and 'V94-5152' was used. Sowonkong have narrow leaflet and 4-seeded pod and V94-5152 have ovate leaflet and do not have 4-seeded pod. The plants of F2 populations showed a segregation ratio of 3:1 of ovate leaflet to narrow leaflet and then leaflet genotypes were obtained from F2:3 population of each F2 individual. The narrow leaflet-containing plants showed Sowonkong-like pod trait and the ovate leaflet-containing plants V94-5152-like pod trait. The results suggested that, in our mapping population, a single gene controls inheritance of the narrow leaflet character and the narrow leaflet trait is tightly linked to or co-segregating with the trait controlling nspp. Subsequently, we mapped the narrow leaflet locus near Sat_105, Satt270 and SM315 on soybean linkage group I that corresponds with the previously known ln locus. Work is ongoing to construct a fine molecular genetic linkage map on this MLG I region and to find a linkage relationship between ln and nspp. Our results should facilitate further elucidation for the relationship between ln/nspp and yield.
Characteristics Evaluation of Peach Genetic Resources for Establishing a Core Collection in Peach
Namhee Jeong,Jung Hyun Kwon,Ju-Hyun Lee,Kidong Hwang,Ji Hae Jun 한국원예학회 2021 한국원예학회 학술발표요지 Vol.2021 No.10
In this study, characteristics evaluation was performed on 441 peach genetic resources in order to establish a core collection in peach. Characteristics evaluation of peach genetic resources was investigated for 3 years (2018-2020) at the National Institute of Horticultural and Herbal Science (Wanju-gun, Jeollabuk-do). Total peach genetic resources consist of 400 varieties for fresh edible, 1 variety for processing, 6 for ornamental, 13 for rootstock, and 21 for unknown. We evaluated characteristics for various traits such as phenological characteristics (e.g., time of beginning of flowering, full bloom stage, and time of maturity), morphological characteristics of the flowers and leaves (e.g., flower type and leaf shape index), and fruit quality factors (e.g., fruit weight, fruit type, pubescence on the fruit skin, flesh color, soluble solids content, and titratable acidity) in peach. As a result of characterization of peach genetic resources, the time of beginning of flowering and full bloom stage were distributed from March 22 to April 15. The time of maturity was also distributed from June 14 to September 28. The flower type was showy (rosette) 79.5% and non showy (campanulate) 20.5%. The leaf shape index ranged from 2.62 to 8.73. In addition, the distribution of fruit weight was investigated from 44.7g to 441.8g. Apporoximately 62.4% of total varieties were white-fleshed peach, while 37.6% were yellow-fleshed peach. In the fruit type, 42.7% of the circular type, 54.1% of the elliptic type, and 3.2% of the oblate type were investigated. Peaches with pubescence on the fruit skin were 78.7% and nectarines were 21.3%, and soluble solids content and titratable acidity were evaluated. The results of characteristics evaluation of these peach genetic resources will be usefully used for the selection of core resources for future breeding programs. Furthermore, the phenotype data generated as these results will be possible genome-wide association studies as well as establishing of peach core collection using the genotype data generated through the whole genome sequencing of peach genetic resources. Taken together, these results will be able to contribute greatly for peach molecular breeding and peach genetic analyses.