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First Report of Dieback Caused by Lasiodiplodia theobromae in Strawberry Plants in Korea
( Myeong Hyeon Nam ),( Myung Soo Park ),( Hyun Sook Kim ),( Tae Il Kim ),( Eun Mo Lee ),( Jong Dae Park ),( Hong Gi Kim ) 한국균학회 2016 Mycobiology Vol.44 No.4
Dieback in strawberry (Seolhyang cultivar) was first observed during the nursery season (June to September) in the Nonsan area of Korea in the years 2012 and 2013. Initial disease symptoms included dieback on runners, as well as black rot on roots, followed by wilting and eventually blackened, necrotic discoloration in the crowns of daughter plants. A fungus isolated from the diseased roots, runners, and crowns is close to Lasiodiplodia theobromae based on morphological characteristics. Analysis of a combined dataset assembled from sequences of the internal transcribed spacer and translation elongation factor 1- alpha genes grouped nine fungal isolates with the type strain of L. theobromae. The isolates showed strong pathogenicity on strawberry cultivars Kumhyang, Seolhyang, and Akihimae, fulfilling Koch`s postulates. Based on these results, the pathogen responsible for dieback on strawberry plants in Korea was identified as L. theobromae.
( Ki Mo Kim ),( Young Guen Kwon ),( Seung Nam Koong ),( Kwon Soo Ha ),( Young Myeong Kim ) 한국지질동맥경화학회 ( 구 한국지질학회 ) 2002 韓國脂質學會誌 Vol.12 No.1
Hyperhomocysteinemia is believed to injure endothelial cells and promote atherosclerosis through a number of mechanisms including the generation of reactive oxygen species (ROS) and suppression of nitric oxide (NO) bioavailability. NO produced by endothel
Regulation of Apoptosis by Nitrosative Stress
Kim, Ki-Mo,Kim, Peter K.M.,Kwon, Young-Guen,Bai, Se-Kyung,Nam, Woo-Dong,Kim, Young-Myeong Korean Society for Biochemistry and Molecular Biol 2002 Journal of biochemistry and molecular biology Vol.35 No.1
Nitrosative stress can prevent or induce apoptosis. It occurs via S-nitrosylation by the interaction of nitric oxide (NO) with the biological thiols of proteins. Cellular redox potential and non-heme iron content determine S-nitrosylation. Apoptotic cell death is inhibited by S-nitrosylation of the redox-sensitive thiol in the catalytic site of caspase family proteases, which play an essential role in the apoptotic signal cascade. Nitrosative stress can also promote apoptosis by the activation of mitochondrial apoptotic pathways, such as the release of cytochrome c, an apoptosis-inducing factor, and endonuclease G from mitochondria, as well as the suppression of NF-${\kappa}B$ activity. In this article we reviewed the mechanisms whereby S-nitrosylation and nitrosative stress regulate the apoptotic signal cascade.
Regulation of Apoptosis by Nitrosative Stress
Kim, Ki Mo,Kim, Young Myeong,Kwon, Young Guen,Kim, Peter K . M .,Bai, Se Kyung,Nam, Woo Dong 생화학분자생물학회 1998 BMB Reports Vol.35 No.1
Nitrosative stress can prevent or induce apoptosis. It occurs via S-nitrosylation by the interaction of nitric oxide (NO) with the biological thiols of proteins. Cellular redox potential and non-heme iron content determine S-nitrosylation. Apoptotic cell death is inhibited by S-nitrosylation of the redox-sensitive thiol in the catalytic site of caspase family proteases, which play an essential role in the apoptotic signal cascade. Nitrosative stress can also promote apoptosis by the activation of mitochondrial apoptotic pathways, such as the release of cytochrome c, an apoptosis-inducing factor, and endonuclease G from mitochondria, as well as the suppression of NF-kB activity. In this article we reviewed the mechanisms whereby S-nitrosylation and nitrosative stress regulate the apoptotic signal cascade.
Bae, Jeong Mo,Shin, So‐,Hyun,Kwon, Hyeong‐,Ju,Park, Seog‐,Yun,Kook, Myeong Cherl,Kim, Young‐,Woo,Cho, Nam‐,Yun,Kim, Nayoung,Kim, Tae‐,You,Kim, Donguk,Kang, Gyeong H Wiley Subscription Services, Inc., A Wiley Company 2012 International journal of cancer: Journal internati Vol.131 No.6
<P><B>Abstract</B></P><P>Focal CpG island hypermethylation and diffuse genomic hypomethylation signify the changes in the DNA methylation status in cancer cells. <I>ALU</I> and <I>LINE‐1</I> repetitive DNA elements comprise ∼28% of the human genome. PCR‐based measurements of these repetitive DNA elements can be used as a surrogate marker of the genomewide methylation content. Our study aimed to identify the timing of <I>ALU</I> and <I>LINE‐1</I> hypomethylations during multistep gastric carcinogenesis and their prognostic implications in gastric cancer (GC). In our study, we analyzed the methylation statuses of <I>ALU</I> and <I>LINE‐1</I> in 249 cases of gastric biopsy samples and another independent set of 198 cases of advanced GC by pyrosequencing. Regardless of the <I>Helicobacter pylori</I> infection status, a significant decrease in the <I>ALU</I> methylation levels was noted during the transitions from chronic gastritis to intestinal metaplasia and from gastric adenoma to GC. <I>LINE‐1</I> methylation decreased during the transition from intestinal metaplasia to gastric adenoma and no further decrease occurred during the transition from gastric adenoma to GC. A low <I>LINE‐1</I> methylation status was strongly associated with poor prognosis in GC. A multivariate analysis revealed that <I>LINE‐1</I> methylation status was an independent prognostic factor. Our findings suggest that <I>ALU</I> and <I>LINE‐1</I> hypomethylations are early events during multistep gastric carcinogenesis. Furthermore, the <I>LINE‐1</I> methylation status can be used as a molecular biomarker to define a subset of GC patients with poor prognosis.</P>
이명훈(Lee Myeong Hun),이근모(Lee Geun Mo),이남미(Lee Nam Mi) 한국사회체육학회 2003 한국사회체육학회지 Vol.19 No.1
This research was performed for understanding various factors affecting the dropout of athletes in junior and senor high school and searching research model which explain the process of the dropout and for examining individual and operating school factors which affected the dropout of school athletes. For this purpose, questions were posed to 48 junior and 51 senior high school dropouts and to 58 junior and 57 senor high school athletes who were still working on athletics. As statistical methods, the frequency analysis for population background analysis, t-test for comparing the average of each factor, the path analysis for inspecting the casual sequences were used. The conclusions are as follows; 1. The effects that the individual factors had on the operating school factors in junior high schools are as follows. (1) It was showed that the social structure factor in the individual factors had an positive effects on the social integration factor in the operating school factors in junior high schools. It was showed that the self consciousness factor in the individual factors had an positive effect on the satisfaction at the sports program, the social integration factor, and the athletic environment factor in junior high schools. The individual environment factor in the individual factors had an positive effect on the satisfaction at the sports program, the social integration factor, and athletic environment factor in junior high schools. (2) In junior high schools, the self consciousness factor in the individual factors had direct and indirect, and negative effects on the dropout. And the social structure factor and the individual environment factor had no direct effects on the dropout and had indirect and negative effects on the dropout. (3) In junior high schools, the operating school factors had no effects on the dropout. 2. The effects that the individual factors had on the operating school factors in senior high schools are as follows. (1) The social structure factor in the individual factors had an negative effect on the satisfaction at the athletic program and the athletic environment factor in the operating school factors in senior high schools. The self consciousness factor in the individual factors had an positive effect on the satisfaction at the athletic program in the operating school factors in senior high schools. The individual environment factor in the individual factors had an positive effect on the satisfaction at the athletic program, the social integration factor, the athletic environment factor in the operating factors in senior high schools. (2) In senior high schools, the self consciousness factor in the individual factors had direct and indirect, and negative effects to the dropout. And the social structure factor and the individual environment factor had no direct effects on the dropout and the individual environment factor had negative and indirect effects on the dropout. (3) In senior high schools, the social integration factor had negative, direct effects on the dropout.