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A case of lichen amyloidosis in an adult
( Jee Yon Shin ),( Myeong Heon Chae ),( Ji Yeoun Lee ),( Tae Young Yoon ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1
Lichen amyloidosis is a type of primary localized cutaneous amyloidosis clinically characterized by persistent pruritic, hyperkeratotic papules commonly distributed on the shins. Histopathologically, amyloid deposition in the papillary dermis is the characteristic finding. It appears to be more common in males and most often occurs in people 50-60 years of age. A 49-year-old woman presented with brownish papuloplaques on the both lower legs. Itching sense was severe and the lesion was occurred 2 years ago. Histopatholgic findings showed amyloid deposit in the papillary dermis. D-PAS staining was negative. Based on these findings, a diagnosis of lichen amyloidosis was made. We think this case has typical chracteristics of lichen amyloidosis. Therefore we report a case of lichen amyloidosis for educational purposes.
SHIN, Myeong-Heon,MIN, Duk-Young 이화여자대학교 생명과학연구소 1996 생명과학연구논문집 Vol.7 No.-
폐흡충(paragonimus westermani)감염시 일어나는 TH cytokine 반응을 알아보고자 마우스에 폐흡충 피낭유충을 감염시킨 후 비장세포를 Con A로 자극하여 TH1-specific cytokine인 IFN-γ와 TH2-specific cytokine인 IL-4의 생산량을 감염시기별로 효소표식 면역검사법으로 측정하였다. 폐흡충 감염 마우스의 비장세포에서 생산되는 IL-4는 감염 후 3일(410±60.9 pg/ml)에 최고치에 도달한 후 2주(343±59.0 pg/ml)까지 대조군에 비해 높게 유지되었으나 감염 후 4주에는 감소되기 시작하여 6주에는 대조군의 생산량과 비슷하였다. 한편 폐흡충 감염 마우스의 비장세포에서 생산되는 IFN-γ는 감염 후 1주(151±32.3 pg/ml)에만 대조군에 비해 높게 증가되었을 뿐 2주부터 감소되기 시작하여 감염 후 6주에는 전혀 측정되지 않아 오히려 대조군의 생산량보다도 적었다. 또한 폐흡충 감염 마우스의 혈청 내 IL-4의 양은 감염 후 4주부터 6주에 대조군에 비해 높게 증가되었으나 혈청내 IFN-γ의 양은 전 실험기간을 통해 측정되지 않았다. 이상의 결과를 종합할 때 폐흡충 감염마우스에서는 IFN-γ보다는 IL-4가 증가되는 TH2 cytokine 반응이 주로 일어남을 알 수 있다. The TH cytokine responses of spleen cells stimulated with Con A from mice infected with Paragonimus westermani were examined. The spleen cell culture supernatants were assayed for TH1-specific IFN-γ and TH2-specific IL-4. Cytokine responses for IL-4 peaked at three days(410±60.9 pg/ml), persisted at a high level until the second week(343±59.0 pg/ml), and then decreased slowly four and six weeks after infection. IFN-γ production by splenocytes only increased during the first week〔151±32.3 pg/ml〕and declined abruptly after the second week of infection. IFN-γ production by splenocytes of infected mice was not observed during the sixth week of infection. In addition, serum IL-4 and IFN-γ were measured. Serum IL-4 was not detected in substantial quantity until four to six weeks after infection. The time course of serum IL-4 was not correlated with that of IL-4 production by splenocytes. Serum IFN-γ was undetectable during the entire course of infection. These results suggest that TH2 cytokine responses, rather than TH1, predominate in mice infected with P.westermani.
Shin, Myeong Heon,Lee, Young-Ah,Bae, Yoe-Sik,Kita, Hirohito,Kim, Youngdong,Ryu, Sung Ho S. Karger AG 2005 International archives of allergy and immunology Vol.137 No.suppl1
<P><I>Background:</I> Eosinophils play a key role in allergic inflammation and parasitic infections. The synthetic peptide, Trp-Lys-Tyr-Met-Val-<I>D</I>-Met (WKYMVm), has been previously shown to activate eosinophils and thus to enhance respiratory burst through the formyl peptide receptors. <I>Objective:</I> This study was undertaken to determine the intracellular signaling pathway involved in WKYMVm-stimulated superoxide production by human eosinophils. <I>Methods:</I> Purified eosinophils from peripheral blood were stimulated with various concentrations (10<SUP>-3</SUP> to 10 μ<I>M</I>) of WKYMVm and the involvement of PI3-kinase and MAP kinases in WKYMVm-triggered superoxide production was investigated using pharmacological inhibitors. <I>Results:</I> WKYMVm-induced superoxide production by eosinophils was strongly inhibited by pretreatment with the PI3-kinase inhibitor LY294002. In addition, pretreatment with the ERK1/2 kinase inhibitor PD98059 resulted in marked inhibition of superoxide production induced by WKYMVm. Indeed, WKYMVm strongly induced phosphorylation of ERK1/2. The ERK1/2 activation by the peptide was transient and peaked after 2 min of stimulation. Furthermore, ERK1/2 activation by WKYMVm was completely inhibited by pretreatment with the PI3-kinase inhibitor LY294002, but not by the PKC inhibitor Ro-31-8220. <I>Conclusion:</I> These results suggest that WKYMVm stimulates human eosinophils to induce superoxide production via a PI3-kinase-mediated ERK1/2 pathway.</P><P>Copyright © 2005 S. Karger AG, Basel</P>