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      • FRAGMENTATION KINEMATICS IN COMET 332P/IKEYA-MURAKAMI

        Jewitt, David,Mutchler, Max,Weaver, Harold,Hui, Man-To,Agarwal, Jessica,Ishiguro, Masateru,Kleyna, Jan,Li, Jing,Meech, Karen,Micheli, Marco,Wainscoat, Richard,Weryk, Robert American Astronomical Society 2016 ASTROPHYSICAL JOURNAL LETTERS - Vol.829 No.1

        <P>We present initial time-resolved observations of the split comet 332P/Ikeya-Murakami taken using the Hubble Space Telescope. Our images reveal a dust-bathed cluster of fragments receding from their parent nucleus at projected speeds in the range 0.06-3.5 m s(-1) from which we estimate ejection times from 2015 October to December. The number of fragments with effective radii greater than or similar to 20 m follows a differential power law with index gamma = -3.6 +/- 0.6, while smaller fragments are less abundant than expected from an extrapolation of this power law. We argue that, in addition to losses due to observational selection, torques from anisotropic outgassing are capable of destroying the small fragments by driving them quickly to rotational instability. Specifically, the spin-up times of fragments. 20 m in radius are shorter than the time elapsed since ejection from the parent nucleus. The effective radius of the parent nucleus is re <= 275 m (geometric albedo 0.04 assumed). This is about seven times smaller than previous estimates and results in a nucleus mass at least 300 times smaller than previously thought. The mass in solid pieces, 2 x 10(9) kg, is about 4% of the mass of the parent nucleus. As a result of its small size, the parent nucleus also has a short spin-up time. Brightness variations in time-resolved nucleus photometry are consistent with rotational instability playing a role in the release of fragments.</P>

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        Binding of EBP50 to Nox organizing subunit p47<sup><i>phox</i></sup> is pivotal to cellular reactive species generation and altered vascular phenotype

        Al Ghouleh, Imad,Meijles, Daniel N.,Mutchler, Stephanie,Zhang, Qiangmin,Sahoo, Sanghamitra,Gorelova, Anastasia,Henrich Amaral, Jefferson,Rodré,,guez, André,s I.,Mamonova, Tatyana,So National Academy of Sciences 2016 Proceedings of the National Academy of Sciences Vol.113 No.36

        <P>Despite numerous reports implicating NADPH oxidases (Nox) in the pathogenesis of many diseases, precise regulation of this family of professional reactive oxygen species (ROS) producers remains unclear. A unique member of this family, Nox1 oxidase, functions as either a canonical or hybrid system using Nox organizing subunit 1 (NoxO1) or p47(phox), respectively, the latter of which is functional in vascular smooth muscle cells (VSMC). In this manuscript, we identify critical requirement of ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50; aka NHERF1) for Nox1 activation and downstream responses. Superoxide (O-2(center dot-)) production induced by angiotensin II (AngII) was absent in mouse EBP50 KO VSMC vs. WT. Moreover, ex vivo incubation of aortas with AngII showed a significant increase in O-2(center dot-)-in WT but not EBP50 or Nox1 nulls. Similarly, lipopolysaccharide (LPS)-induced oxidative stress was attenuated in femoral arteries from EBP50 KO vs. WT. In silico analyses confirmed by confocal microscopy, immunoprecipitation, proximity ligation assay, FRET, and gain-/ loss-of-function mutagenesis revealed binding of EBP50, via its PDZ domains, to a specific motif in p47(phox). Functional studies revealed AngII-induced hypertrophy was absent in EBP50 KOs, and in VSMC overexpressing EBP50, Nox1 gene silencing abolished VSMC hypertrophy. Finally, ex vivo measurement of lumen diameter in mouse resistance arteries exhibited attenuated AngII-induced vasoconstriction in EBP50 KO vs. WT. Taken together, our data identify EBP50 as a previously unidentified regulator of Nox1 and support that it promotes Nox1 activity by binding p47(phox). This interaction is pivotal for agonist-induced smooth muscle ROS, hypertrophy, and vasoconstriction and has implications for ROS-mediated physiological and pathophysiological processes.</P>

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        HUBBLE SPACE TELESCOPE INVESTIGATION OF MAIN-BELT COMET 133P/ELST-PIZARRO

        Jewitt, David,Ishiguro, Masateru,Weaver, Harold,Agarwal, Jessica,Mutchler, Max,Larson, Steven American Institute of Physics 2014 The Astronomical journal Vol.147 No.5

        <P>We report new observations of the prototype main-belt comet (active asteroid) 133P/Elst-Pizarro taken at high angular resolution using the Hubble Space Telescope. The object has three main components: (1) a point-like nucleus; (2) a long, narrow antisolar dust tail; and (3) a short, sunward anti-tail. There is no resolved coma. The nucleus has a mean absolute magnitude H<SUB>V</SUB> = 15.70 ± 0.10 and a light curve range ΔV = 0.42 mag, the latter corresponding to projected dimensions 3.6 × 5.4 km (axis ratio 1.5:1) at the previously measured geometric albedo of 0.05 ± 0.02. We explored a range of continuous and impulsive emission models to simultaneously fit the measured surface brightness profile, width, and position angle of the antisolar tail. Preferred fits invoke protracted emission, over a period of 150 days or less, of dust grains following a differential power-law size distribution with index 3.25 ≤q ≤ 3.5 and with a wide range of sizes. Ultra-low surface brightness dust projected in the sunward direction is a remnant from emission activity occurring in previous orbits, and consists of the largest (≥cm-sized) particles. Ejection velocities of one-micron-sized particles are comparable to the ~1.8 m s<SUP>–1</SUP> gravitational escape speed of the nucleus, while larger particles are released at speeds less than the gravitational escape velocity. The observations are consistent with, but do not prove, a hybrid hypothesis in which mass loss is driven by gas drag from the sublimation of near-surface water ice, but escape is aided by centripetal acceleration from the rotation of the elongated nucleus. No plausible alternative hypothesis has been identified.</P>

      • A WFC3 study of globular clusters in NGC 4150: an early‐type minor merger

        Kaviraj, Sugata,Crockett, R. Mark,Whitmore, Bradley C.,Silk, Joseph,O’Connell, Robert W.,Windhorst, Rogier A.,Mutchler, Max,Rejkuba, Marina,Yi, Sukyoung,Frogel, Jay A.,Calzetti, Daniela Blackwell Publishing Ltd 2012 Monthly notices of the Royal Astronomical Society. Vol.422 No.1

        <P><B>ABSTRACT</B></P><P>We combine near‐ultraviolet (NUV; 2250 Å) and optical (<I>U</I>, <I>B</I>, <I>V</I>, <I>I</I>) imaging from the Wide Field Camera 3 (WFC3), on‐board the <I>Hubble Space Telescope</I> (<I>HST</I>), to study the globular cluster (GC) population in NGC 4150, a sub‐L* (<I>M</I><SUB><I>B</I></SUB>∼−18.48 mag) early‐type minor‐merger remnant in the Coma I cloud. We use broad‐band NUV–optical photometry from the WFC3 to estimate individual ages, metallicities, masses and line‐of‐sight extinctions [<I>E</I>(<I>B</I>−<I>V</I>)] for 63 bright (<I>M</I><SUB><I>V</I></SUB> < −5 mag) GCs in this galaxy. In addition to a small GC population with ages greater than 10 Gyr, we find a dominant population of clusters with ages centred around 6 Gyr, consistent with the expected peak of stellar mass assembly in faint early types residing in low‐density environments. The old and intermediate‐age GCs in NGC 4150 are metal poor, with metallicities less than 0.1 Z<SUB>⊙</SUB>, and reside in regions of low extinction [<I>E</I>(<I>B</I>−<I>V</I>) < 0.05 mag]. We also find a population of young, metal‐rich (<I>Z</I> > 0.3 Z<SUB>⊙</SUB>) clusters that have formed within the last Gyr and reside in relatively dusty [<I>E</I>(<I>B</I>−<I>V</I>) > 0.3 mag] regions that are coincident with the part of the galaxy core that hosts significant recent star formation. Cluster disruption models (in which ∼80–90 per cent of objects younger than a few ×10<SUP>8</SUP> yr dissolve every dex in time) suggest that the bulk of these young clusters are a transient population.</P>

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