Theoretical study of cross sections of proton-induced reactions on cobalt

Mustafa Yigit 한국원자력학회 2018 Nuclear Engineering and Technology Vol.50 No.3

Nuclear fusion may be among the strongest sustainable ways to replace fossil fuels because it does notcontribute to acid rain or global warming. In this context, activated cobalt materials in corrosion productsfor fusion energy are significant in determination of dose levels during maintenance after a coolant leakin a nuclear fusion reactor. Therefore, cross-section studies on cobalt material are very important forfusion reactor design. In this article, the excitation functions of some nuclear reaction channels inducedby proton particles on 59Co structural material were predicted using different models. The nuclear leveldensities were calculated using different choices of available level density models in ALICE/ASH code. Finally, the newly calculated cross sections for the investigated nuclear reactions are compared with theexperimental values and TENDL data based on TALYS nuclear code.

Study on (n,p) reactions of ^{58,60,61,62,64}Ni using new developed empirical formulas

Yigit, Mustafa Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.4

Nuclear fusion seems to be a good choice of energy source in the future. Nickel is one of the crucial structural materials for fusion devices. In this work, the cross section data of ⁵⁸Ni(n,p)⁵⁸Co, ⁶⁰Ni(n,p)⁶⁰Co, ⁶¹Ni(n,p)⁶¹Co, ⁶²Ni(n,p)⁶²Co and ⁶⁴Ni(n,p)⁶⁴Co reactions were calculated using the nuclear codes ALICE/ASH, EMPIRE 3.2 and TALYS 1.8. In addition, the cross sections were calculated with the empirical formulas obtained in our previous paper at 14-15 MeV. The obtained results were compared with the measured values in the literature, and with the evaluated data files (JEFF-3.3, TENDL-2017, ENDF/B-VIII.0).

Routine calcitonin measurement in nodular thyroid disease management: is it worthwhile?

Yigit Turk,Ozer Makay,Murat Ozdemir,Gozde Ertunc,Batuhan Demir,Gokhan Icoz,Mahir Akyildiz,Mustafa Yilmaz 대한외과학회 2017 Annals of Surgical Treatment and Research(ASRT) Vol.92 No.4

Purpose: To evaluate the diagnostic accuracy of routine calcitonin measurement in patients with nodular thyroid disease. Methods: Consecutive patients with nodular thyroid disease (n = 640) were studied. Serum calcitonin levels were measured under basal conditions, and when basal values were between 10–100 pg/mL, testing was repeated after pentagastrin (PG) stimulation. Patients with previously diagnosed or familial medullary thyroid cancer (MTC) were excluded. Patients were operated on when basal or stimulated calcitonin >100 pg/mL or when other surgical indications were present. Results: Four cases of MTC were identified. MTC was diagnosed in 75% of patients with basal calcitonin >100 pg/mL. One out of 11 patients with basal calcitonin between 10–100 pg/mL was diagnosed with MTC. PG stimulation resulted in elevation in 4 cases, where 1 case was diagnosed with MTC. Positive predictive value for basal calcitonin levels in the preoperative diagnosis of MTC was 5% for values between 10–100 pg/mL and 100% for values >100 pg/mL. Possible reasons for false positivity were papillary thyroid cancer in 17%, renal insufficiency in 8.3%, Hashimoto thyroiditis in 17% and β-blocker use in 33%. Positive predictive value for the PG test (>100 pg/mL) was 25% in the entire series. The cost of adding calcitonin measurement (±PG stimulation) to the preoperative work-up, resulted in €912.68 per MTC patient to detect the disease. Conclusion: Basal calcitonin measurement together with PG stimulation in cases of basal calcitonin >10 pg/mL detects MTC in 0.62% of patients with nodular thyroid disease.

Preconcentration–separation of germanium at ultra trace levels on polysulfone membrane filter and its determination by spectrophotometry

Mustafa Soylak,Sevtap Yigit 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.24 No.-

A separation–preconcentration procedure for germanium has been presented. The optimum conditions including pH, sample volume, sample-eluent flow rates, sample and matrix effects for adsorption of germanium(IV) on polysulfone membrane filter were investigated prior to spectrophotometric determination of germanium as Ge(IV)-9-phenyl-3-fluorone complex. Ge(IV) was adsorbed on membrane at pH 4.0 and was eluted from membrane with phosphoric acid. The accuracy was checked by determination of germanium content of GBW 07402 soil certified reference material. The detection and quantification limits were found as 2.1 and 7.0 ng/L, respectively. The method was applied for determination of germanium in soil and water samples.

Prognostic Significance of Circulating Tumor Cells and Serum CA15-3 Levels in Metastatic Breast Cancer, Single Center Experience, Preliminary Results

Tarhan, Mustafa Oktay,Gonel, Ataman,Kucukzeybek, Yuksel,Erten, Cigdem,Cuhadar, Serap,Yigit, Seyran Ceri,Atay, Aysenur,Somali, Isil,Dirican, Ahmet,Demir, Lutfiye,Koseoglu, Mehmet Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Background: Breast cancer is the second leading cancer causing death in women. Circulating tumor cells are among the prognostic factors while tumor markers are of diagnostic value and can be used for follow-up. The aim of this study was to investigate the correlation between the prognostic significance of the serum CA15-3 levels, number of circulating tumor cells and histopathological tumor factors. Materials and Methods: Thirty patients recently diagnosed with breast cancer were included in the study. Number of circulating tumor cells and serum CA15-3 level were assessed when metastasis was detected and diagnostic value was assessed. Presence of associations with estrogen and progesterone receptors, c-erbB2, Ki-67 proliferation index and histological grade were also evaluated. Results: Median overall survival of the patients with serum CA15-3 levels of >108 ng/dl was 19 months whereas for those with a low serum level it was 62 months. Median overall survival for CTC ${\geq}5$ vs CTC<5 patients was 19 months and 40 months respectively. The difference between the two groups was statistically significant. Conclusions: Prognostic significance of the CTC count and CA15-3 levels in metastatic breast cancer patients was demonstrated.

Hormone Receptor, HER2/NEU and EGFR Expression in Ovarian Carcinoma - is here a Prognostic Phenotype?

Demir, Lutfiye,Yigit, Seyran,Sadullahoglu, Canan,Akyol, Murat,Cokmert, Suna,Kucukzeybek, Yuksel,Alacacioglu, Ahmet,Cakalagaoglu, Fulya,Tarhan, Mustafa Oktay Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22

Purpose: We aimed to evaluate the effects of hormone receptor, HER2, and epidermal growth factor receptor (EGFR) expression on epithelial ovarian cancer (EOC) prognosis and investigate whether or not phenotypic subtypes might exist. Materials and Methods: The medical records of 82 patients who were diagnosed with EOC between 2003 and 2012 and treated by platinum-based chemotherapy were retrospectively evaluated. Expression of EGFR, oestrogen (ER), progesterone (PR), and cerbB2 (HER2) receptors were assessed immunohistochemically on paraffin-embedded tissues of these patients. Three phenotypic subtypes were defined according to ER, PR, and HER2 expression and associations of these with EGFR expression, clinicopathologic features, platinum sensitivity, and survival were investigated. Results: When we classified EOC patients into three subtypes, 63.4% had hormone receptor positive (HR(+)) (considering breast cancer subtypes, luminal A), 18.3% had triple negative, and 18.3% had HER2(+) disease. EGFR positivity was observed in 37 patients (45.1%) and was significantly more frequent with advanced disease (p=0.013). However, no significant association with other clinicopathologic features and platinum sensitivity was observed. HER2(+) patients had significantly poorer outcomes than HER2(-) counterparts (triple negative and HR positive patients) (p=0.019). Multivariate analysis demonstrated that the strongest risk factor for death was residual disease after primary surgery. Conclusions: Triple negative EOC may not be an aggressive phenotype as in breast cancer. The HER2 positive EOC has more aggressive behaviour compared to triple negative and HR(+) phenotypes. EGFR expression is more frequent in advanced tumours, but is not related with poorer outcome. Additional ovarian cancer molecular subtyping using gene expression analysis may provide more reliable data.

Clinicopathologic and Demographic Evaluation of Triple-Negative Breast Cancer Patients among a Turkish Patient Population: a Single Center Experience

Somali, Isil,Ustaoglu, Bahar Yakut,Tarhan, Mustafa Oktay,Yigit, Seyran Ceri,Demir, Lutfiye,Ellidokuz, Hulya,Erten, Cigdem,Alacacioglu, Ahmet Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Background: To evaluate the clinicopathologic and demographic characteristics of triple-negative breast cancer (TNBC) patients and to determine differences from non-triple-negative cases. Materials and Methods: A detailed review of the medical records of 882 breast cancer (BC) patients was conducted to obtain information regarding age, menopausal status, height and weight at the time of diagnosis, presence of diabetes or hypertension, and pathologic characteristics of the tumor (tumor size, lymph node status, histologic grade, ER status, PR status, HER2 status, p53 mutation). Body mass index (BMI) was calculated and a value of ${\geq}30$ was considered as indicative of obesity. Results: 14.9% (n=132) of the patients had TNBC. There was no difference among the patients in terms of median age, comorbid conditions and menopausal status. The proportion of medullary, tubular and mucinous carcinomas was significantly higher (15.9%) in the triple-negative (TN) group, while invasive lobular histology was more frequent (8.2%) among non-triple negative (NTN) cases (p<0.001). Grade 3 (G3) tumors were more frequent in the triple-negative group (p<0.001). The rate of p53 mutation was 44.3% in TN tumors versus 28.2% in the NTN group (p<0.001). The two groups were similar in terms of LN metastasis. In the NTN group, the rate of patients with BMI ${\geq}30$ was 53% among postmenopausal patients, while it was 36% among premenopausal women, and the difference was statistically significant (p<0.001). No significant difference was observed in terms of BMI between postmenopausal and premenopausal patients in the TN group (p=0.08). Conclusions: TNBC rates and clinicopathologic characteristics of the Turkish patient population were consistent with the data from Europe and America. However, no relationship between obesity and TNBC was observed in our study. The association between TNBC and obesity needs to be evaluated in a larger patient population.