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Antihyperlipidemic Effect of Scoparia dulcis (Sweet Broomweed) in Streptozotocin Diabetic Rats
Leelavinothan Pari,Muniappan Latha 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.1
We have investigated Scoparia dulcis, an indigenous plant used in Ayurvedic medicine in India, for its possi-ble antihyperlipidemic effect in rats with streptozotocin-induced experimental diabetes. Oral administration of an aqueous ex-tract of S. dulcisplant (200 mg/kg of body weight) to streptozotocin diabetic rats for 6 weeks resulted in a significant reduc-tion in blood glucose, serum and tissue cholesterol, triglycerides, free fatty acids, phospholipids, 3-hydroxy-3-methylglutaryl(HMG)-CoA reductase activity, and very low-density lipoprotein and low-density lipoprotein cholesterol levels. The decreasedserum high-density lipoprotein cholesterol, anti-atherogenic index, and HMG-CoA reductase activity in diabetic rats were alsoreversed towards normalization after the treatment. Similarly, the administration of S. dulcis plant extract (SPEt) to normalanimals resulted in a hypolipidemic effect. The effect was compared with glibenclamide (600 .g/kg of body weight). The re-sults showed that SPEt had antihyperlipidemic action in normal and experimental diabetic rats in addition to its antidiabeticeffect.
Vengatesh Narmatha Bai,Rajendran Ananthan,Muniappan Latha,Leelavinothan Pari,Kunga Mohan Ramkumar,Chokkanna Gounder Baskar 한국식품영양과학회 2003 Journal of medicinal food Vol.6 No.1
The effects of Gymnema montanum , an endangered plant used in the ancient period of India,on blood glucose, plasma insulin, and carbohydrate metabolic enzymes were studied in al-loxan diabetic rats. Administration of alcoholic extract of G. montanum leaves (50, 10, 20mg/kg body weight) to alloxan diabetic rats for 3 weks reduced the blood glucose level. Ad-ministration of G. montanum leaf extract (GLEt) at 200 mg/kg body weight significantly de-creased the blood glucose levels and significantly increased the plasma insulin levels. Thisclearly shows the antidiabetic efficacy of GLEt, which was better than that of glibenclamide.43