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Leelavinothan Pari,Subramanian Venkateswaran,Ganesan Saravanan 한국식품영양과학회 2002 Journal of medicinal food Vol.5 No.2
The effect of Phaseolus vulgaris , an indigenous plant used in ayurvedic medicine in India,on circulatory antioxidants and lipids was studied in rats with streptozotocin-induced dia-betes. Oral administration of an aqueous extract of P. vulgaris pods (PPEt, 20 mg/kg bodyweight) for 45 days significantly reduced the elevated blood glucose, serum triglycerides, frefatty acids, phospholipids, total cholesterol, very-low-density lipoprotein cholesterol, andlow-density lipoprotein cholesterol. The extract also caused a significant decrease in plasmathiobarbituric acid-reactive substances (TBARS), hydroperoxides, vitamin E, and ceruloplas-min. The decreased serum levels of high-density lipoprotein cholesterol, antiatherogenic in-dex (AAI), plasma insulin, vitamin C, and glutathione in the diabetic rats were also reversedtoward normalization. The results show the antioxidant and antihyperlipidemic properties ofPEt in adition to its antidiabetic action. PEt was found to be more effective than gliben-clamide.97
Leelavinothan Pari,Subramanian Venkateswaran 한국식품영양과학회 2004 Journal of medicinal food Vol.7 No.2
The present investigation was carried out to evaluate the effect of Phaseolus vulgaris, an indigenous plant used in Unani and Ayurvedic medicine in India, on blood glucose, plasma insulin, cholesterol, triglycerides, free fatty acids, phospholipids, and fatty acid composition of total lipids in liver, kidney, and brain of normal and streptozotocin (STZ) diabetic rats. The results show that there was a significant increase in tissue cholesterol, triglycerides, free fatty acids, and phospholipids in STZ diabetic rats. The analysis of fatty acids showed that there was a significant increase in the concentrations of palmitic acid (16:1), stearic acid (18:0), and oleic acid (18:1) in liver, kidney, and brain, whereas the concentrations of linolenic acid (18:3) and arachidonic acid (20:4) were significantly decreased. Oral administration of the aqueous extract of P. vulgaris pods (200 mg/kg of body weight) for 45 days to diabetic rats decreased the concentrations of lipids and fatty acids, viz., palmitic, stearic, and oleic acids, whereas linolenic and arachidonic acids were elevated. Similarly, the administration of P. vulgaris pod extract (PPEt) to normal animals resulted in a significant hypolipidemic effect. These results suggest that PPEt exhibits hypoglycemic and hypolipidemic effects in STZ diabetic rats. It also prevents the fatty acid changes produced during diabetes. The effect of PPEt at 200 mg/kg of body weight was better than that of glibenclamide.
Tetrahydrocurcumin Prevents Brain Lipid Peroxidation in Streptozotocin-Induced Diabetic Rats
Leelavinothan Pari,Pidaran Murugan 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.2
Oxidative damage has been suggested to be a contributory factor in the development and complication of di-abetes. To investigate the effect of tetrahydrocurcumin (THC) on the occurrence of oxidative stress in the brain of rats dur-ing diabetes, we investigated the extent of oxidative damage as well as the status of the antioxidant defense system. Oral ad-ministration of THC at 80 mg/kg of body weight to diabetic rats for 45 days resulted in a significant reduction in blood glucoseand significant increase in plasma insulin levels. In addition, THC caused significant increases in the activities of superoxidedismutase, catalase, glutathione peroxidase, glutathione S-transferase, and reduced glutathione in the brains of diabetic ratswith significant decrease in the lipid peroxidative markers thiobarbituric acid-reactive substances and hydroperoxides in brain,suggesting efficacy for protection against lipid peroxidation-induced membrane damage. The effect of THC was greater thanthat of curcumin. Results of the present study suggest that THC showed antioxidant effects in addition to its antidiabetic ef-fect in type 2 diabetic rats.
Antihyperlipidemic Effect of Scoparia dulcis (Sweet Broomweed) in Streptozotocin Diabetic Rats
Leelavinothan Pari,Muniappan Latha 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.1
We have investigated Scoparia dulcis, an indigenous plant used in Ayurvedic medicine in India, for its possi-ble antihyperlipidemic effect in rats with streptozotocin-induced experimental diabetes. Oral administration of an aqueous ex-tract of S. dulcisplant (200 mg/kg of body weight) to streptozotocin diabetic rats for 6 weeks resulted in a significant reduc-tion in blood glucose, serum and tissue cholesterol, triglycerides, free fatty acids, phospholipids, 3-hydroxy-3-methylglutaryl(HMG)-CoA reductase activity, and very low-density lipoprotein and low-density lipoprotein cholesterol levels. The decreasedserum high-density lipoprotein cholesterol, anti-atherogenic index, and HMG-CoA reductase activity in diabetic rats were alsoreversed towards normalization after the treatment. Similarly, the administration of S. dulcis plant extract (SPEt) to normalanimals resulted in a hypolipidemic effect. The effect was compared with glibenclamide (600 .g/kg of body weight). The re-sults showed that SPEt had antihyperlipidemic action in normal and experimental diabetic rats in addition to its antidiabeticeffect.
Vengatesh Narmatha Bai,Rajendran Ananthan,Muniappan Latha,Leelavinothan Pari,Kunga Mohan Ramkumar,Chokkanna Gounder Baskar 한국식품영양과학회 2003 Journal of medicinal food Vol.6 No.1
The effects of Gymnema montanum , an endangered plant used in the ancient period of India,on blood glucose, plasma insulin, and carbohydrate metabolic enzymes were studied in al-loxan diabetic rats. Administration of alcoholic extract of G. montanum leaves (50, 10, 20mg/kg body weight) to alloxan diabetic rats for 3 weks reduced the blood glucose level. Ad-ministration of G. montanum leaf extract (GLEt) at 200 mg/kg body weight significantly de-creased the blood glucose levels and significantly increased the plasma insulin levels. Thisclearly shows the antidiabetic efficacy of GLEt, which was better than that of glibenclamide.43