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Anthocyanin-Rich Grape Extract Blocks Breast Cell DNA Damage
Keith W. Singletary,Kwan-Jae Jung,Monica Giusti 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.2
Anthocyanins, belonging to the flavonoid family of phytochemicals, have received attention as agents that mayhave potential in preventing chronic diseases such as cardiovascular diseases and certain cancers. In the present study, an an-thocyanin-rich extract from Concord grapes [referred to as Concord grape extract (CGE)] and the anthocyanin delphinidinwere evaluated for their capacity to inhibit DNA adduct formation due to the environmental carcinogen benzo[a]pyrene (BP)in MCF-10F cells, a noncancerous, immortalized human breast epithelial cell line. CGE at 10 and 20 .g/mL and delphinidinat 0.6 .M concentrations significantly inhibited BPDNA adduct formation. This was associated with a significant increasein activities of the phase II detoxification enzymes glutathione S-transferase and NAD(P)H:quinone reductase 1. In addition,these grape components also suppressed reactive oxygen species (ROS) formation, but did not induce antioxidant responseelement-dependent transcription. Taken together, these data suggest that CGE and a component grape anthocyanin have breastcancer chemopreventive potential due in part to their capacity to block carcinogenDNA adduct formation, modulate activi-ties of carcinogen-metabolizing enzymes, and suppress ROS in these noncancerous human breast cells.
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