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Mehrzad Tahamouli Roudsari,Shohreh Sohaei,Morteza Torkaman,Seyed Ali Safaee,Salar Tahmasebi,Saleh Mohammadi,Mohammad Mehdi Ghiasvand 한국강구조학회 2020 International Journal of Steel Structures Vol.20 No.2
Connections play an important role in the response of steel moment resisting frames to seismic loading. Prequalified rigid connections are applicable to I-shaped or box columns. In I-shape beam to concrete-filled tube (CFT) column connections, continuity and doubler plates cannot be added to the column. Various details have been proposed to address this issue, many of which are not constructionally convenient to implement. The aim of this study is to present a simple and suitable detailing for I-shape beam to concrete-filled tube column connections. To that end, six full-scale experimental samples were built and subjected to cyclic quasi-static loading. In the samples, stiffened and un-stiffened channel links were used to connect the beam to the column. In each sample, the stiffeners were installed on a different position on the channel link. The results showed that compared to the connection in which the beam is directly connected to the column, using the stiffened channel link with stiffeners along the beam’s flange increases the strength and ductility of the connection by 12% and 72%, respectively. Considering their desirable performance and easy implementation, these connections can be considered as a suitable detailing for I-shape beam to CFT column connections in seismic regions.
Pashaki, Abdolazim Sedighi,Hamed, Ehsan Akbari,Mohamadian, Kamal,Abassi, Mohammad,Safaei, Afsane Maddah,Torkaman, Tayebe Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6
Background: Glioblastoma multiform (GBM) is a highly aggressive tumor with median survival of approximately 14 months. Management consists of maximal surgical resection followed by post-operative chemoradiation with concurrent then adjuvant temozolamide. The standard radiotherapy dose is 60Gy in 2-Gy fractions recommended by the radiation therapy oncology group (RTOG). With the vast majority of tumor recurrences occurring within the previous irradiation field and the poor outcome associated with standard therapy, regimens designed to deliver higher radiation doses to improve local control and enhance survival are needed. In this study, we report a single institutional experience in treatment of 68 consecutive patients with GBM, treated with resection, and given post-operative radiotherapy followed by concurrent and/or adjuvant chemotherapy. Results: Of the 80 patients who entered this study, 68 completed the treatment course; 45 (66.2%) males and 23 (33.8%) females with a mean age at diagnosis of $49.0{\pm}12.9$ (21-75) years. At a median follow up of 19 months, 39 (57.3%) patients had evidence of tumor progression and 36 (52.9%) had died. The median over all survival for all patients was 16 months and progression free survival for all patients was 6.02 months. All potential prognostic factors were analyzed to evaluate their effects on overall survival. Age ${\leq}50$ year, concurrent and adjuvant chemotherapy and extent of surgery had significant p values. We found lower progression rate among patients who received higher doses of radiotherapy (>60Gy). Higher radiation doses improved progression free survival (p=0.03). Despite increasing overall survival, this elevation was not significant. Conclusions: This study emphasize that higher radiation doses of (>60Gy) can improve local control and potentially survival, so we strongly advise prospective multi centric studies to evaluate the role of higher doses of radiotherapy on GBM patient outcome.
Neuroprotective Agents in the Intensive Care Unit -Neuroprotective Agents in ICU -
Yunes Panahi,Mojtaba Mojtahedzadeh,Atabak Najafi,Seyyed Mahdi Rajaee,Mohammad Torkaman,Amirhossein Sahebkar 대한약침학회 2018 Journal of pharmacopuncture Vol.21 No.4
Neuroprotection or prevention of neuronal loss is a complicated molecular process that is mediated by various cellular pathways. Use of different pharmacological agents as neuroprotectants has been reported especially in the last decades. These neuroprotective agents act through inhibition of inflammatory processes and apoptosis, attenuation of oxidative stress and reduction of free radicals. Control of this injurious molecular process is essential to the reduction of neuronal injuries and is associated with improved functional outcomes and recovery of the patients admitted to the intensive care unit. This study reviews neuroprotective agents and their mechanisms of action against central nervous system damages.
Neuroprotective Agents in the Intensive Care Unit -Neuroprotective Agents in ICU -
Panahi, Yunes,Mojtahedzadeh, Mojtaba,Najafi, Atabak,Rajaee, Seyyed Mahdi,Torkaman, Mohammad,Sahebkar, Amirhossein KOREAN PHARMACOPUNCTURE INSTITUTE 2018 Journal of pharmacopuncture Vol.21 No.4
Neuroprotection or prevention of neuronal loss is a complicated molecular process that is mediated by various cellular pathways. Use of different pharmacological agents as neuroprotectants has been reported especially in the last decades. These neuroprotective agents act through inhibition of inflammatory processes and apoptosis, attenuation of oxidative stress and reduction of free radicals. Control of this injurious molecular process is essential to the reduction of neuronal injuries and is associated with improved functional outcomes and recovery of the patients admitted to the intensive care unit. This study reviews neuroprotective agents and their mechanisms of action against central nervous system damages.